Mapping Alzheimer’s disease pathology using free water through integrated analysis of plasma biomarkers, microstructural DTI metrics, and macrostructural MRI measures

Mapping Alzheimer’s disease pathology using free water through integrated analysis of plasma biomarkers, microstructural DTI metrics, and macrostructural MRI measures

Abstract Alzheimer’s disease (AD) is characterized by amyloid-beta (Aβ) and tau pathologies that drive neuroinflammation and neurodegeneration. Free water (FW), a diffusion tensor imaging (DTI) metric reflecting extracellular fluid changes, has emerged as a sensitive marker of neuroinflammation. Thi...

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Bibliographic Details
Main Authors: Bo-Hyun Kim, Daeun Shin, Sung Hoon Kang, Hyemin Jang, Jihwan Yun, YuHyun Park, Henrik Zetterberg, Kaj Blennow, Fernando Gonzalez-Ortiz, Nicholas J. Ashton, Sung Tae Kim, Hee Jin Kim, Duk L. Na, Jun Pyo Kim, Sang Won Seo
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Plasma biomarkers
Alzheimer’s disease
Diffusion tensor image
Free water macrostructure
Microstructure
Online Access:https://doi.org/10.1038/s41598-025-14200-y
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https://doi.org/10.1038/s41598-025-14200-y

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