Gene by Sex Interaction for Measures of Obesity in the Framingham Heart Study
Obesity is an increasingly prevalent and severe health concern with a substantial heritable component and marked sex differences. We sought to determine if the effect of genetic variants also differed by sex by performing a genome-wide association study modeling the effect of genotype-by-sex interac...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2011/329038 |
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| author | Ashlee M. Benjamin Sunil Suchindran Kaela Pearce Jennifer Rowell Lillian F. Lien John R. Guyton Jeanette J. McCarthy |
| author_facet | Ashlee M. Benjamin Sunil Suchindran Kaela Pearce Jennifer Rowell Lillian F. Lien John R. Guyton Jeanette J. McCarthy |
| author_sort | Ashlee M. Benjamin |
| collection | DOAJ |
| description | Obesity is an increasingly prevalent and severe health concern with a substantial heritable component and marked sex differences. We sought to determine if the effect of genetic variants also differed by sex by performing a genome-wide association study modeling the effect of genotype-by-sex interaction on obesity phenotypes. Genotype data from individuals in the Framingham Heart Study Offspring cohort were analyzed across five exams. Although no variants showed genome-wide significant gene-by-sex interaction in any individual exam, four polymorphisms displayed a consistent BMI association (P-values .00186 to .00010) across all five exams. These variants were clustered downstream of LYPLAL1, which encodes a lipase/esterase expressed in adipose tissue, a locus previously identified as having sex-specific effects on central obesity. Primary effects in males were in the opposite direction from females and were replicated in Framingham Generation 3. Our data support a sex-influenced association between genetic variation at the LYPLAL1 locus and obesity-related traits. |
| format | Article |
| id | doaj-art-5a191be189a74684930f183bcc347e16 |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-5a191be189a74684930f183bcc347e162025-02-03T01:23:40ZengWileyJournal of Obesity2090-07082090-07162011-01-01201110.1155/2011/329038329038Gene by Sex Interaction for Measures of Obesity in the Framingham Heart StudyAshlee M. Benjamin0Sunil Suchindran1Kaela Pearce2Jennifer Rowell3Lillian F. Lien4John R. Guyton5Jeanette J. McCarthy6Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USADuke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USADuke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USADivision of Endocrinology, Metabolism and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USADivision of Endocrinology, Metabolism and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USADivision of Endocrinology, Metabolism and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USADuke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USAObesity is an increasingly prevalent and severe health concern with a substantial heritable component and marked sex differences. We sought to determine if the effect of genetic variants also differed by sex by performing a genome-wide association study modeling the effect of genotype-by-sex interaction on obesity phenotypes. Genotype data from individuals in the Framingham Heart Study Offspring cohort were analyzed across five exams. Although no variants showed genome-wide significant gene-by-sex interaction in any individual exam, four polymorphisms displayed a consistent BMI association (P-values .00186 to .00010) across all five exams. These variants were clustered downstream of LYPLAL1, which encodes a lipase/esterase expressed in adipose tissue, a locus previously identified as having sex-specific effects on central obesity. Primary effects in males were in the opposite direction from females and were replicated in Framingham Generation 3. Our data support a sex-influenced association between genetic variation at the LYPLAL1 locus and obesity-related traits.http://dx.doi.org/10.1155/2011/329038 |
| spellingShingle | Ashlee M. Benjamin Sunil Suchindran Kaela Pearce Jennifer Rowell Lillian F. Lien John R. Guyton Jeanette J. McCarthy Gene by Sex Interaction for Measures of Obesity in the Framingham Heart Study Journal of Obesity |
| title | Gene by Sex Interaction for Measures of Obesity in the Framingham Heart Study |
| title_full | Gene by Sex Interaction for Measures of Obesity in the Framingham Heart Study |
| title_fullStr | Gene by Sex Interaction for Measures of Obesity in the Framingham Heart Study |
| title_full_unstemmed | Gene by Sex Interaction for Measures of Obesity in the Framingham Heart Study |
| title_short | Gene by Sex Interaction for Measures of Obesity in the Framingham Heart Study |
| title_sort | gene by sex interaction for measures of obesity in the framingham heart study |
| url | http://dx.doi.org/10.1155/2011/329038 |
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