Low-Frequency Repetitive Transcranial Magnetic Stimulation over Right Dorsolateral Prefrontal Cortex in Parkinson’s Disease
Background. Repetitive transcranial magnetic stimulation (rTMS) is a promising therapeutic tool for Parkinson’s disease (PD), and many stimulation targets have been implicated. We aim to explore whether low-frequency rTMS over the right dorsolateral prefrontal cortex (DLPFC) improves motor and nonmo...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2020/7295414 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832547703481958400 |
|---|---|
| author | Sheng Zhuang Fu-Yu Wang Xin Gu Jia-Jing Wu Cheng-Jie Mao Hao Gui Jing Chen Chun-Feng Liu |
| author_facet | Sheng Zhuang Fu-Yu Wang Xin Gu Jia-Jing Wu Cheng-Jie Mao Hao Gui Jing Chen Chun-Feng Liu |
| author_sort | Sheng Zhuang |
| collection | DOAJ |
| description | Background. Repetitive transcranial magnetic stimulation (rTMS) is a promising therapeutic tool for Parkinson’s disease (PD), and many stimulation targets have been implicated. We aim to explore whether low-frequency rTMS over the right dorsolateral prefrontal cortex (DLPFC) improves motor and nonmotor symptoms of individuals with PD. Methods. We conducted a randomized, single-blind, sham-controlled parallel trial to compare the effect of 10 consecutive daily sessions of 1 Hz rTMS over right DLPFC on individuals with idiopathic PD between active and sham rTMS group. Primary outcomes were changes in Unified Parkinson’s Disease Rating Scale (UPDRS) part III and Nonmotor Symptom Questionnaire (NMSQ). Secondary outcomes were changes in UPDRS total score, Hamilton Rating Scale for Depression (HRSD), Pittsburgh Sleep Quality Index (PSQI), and Montreal Cognitive Assessment (MoCA). Assessments were completed at baseline, after treatment, and at 1 month, 3 months, and 6 months after treatment. Results. A total of 33 participants with PD were randomized. All participants completed the study and no severe adverse effect was noticed. Compared to baseline, active rTMS showed significant improvements in UPDRS part III and NMSQ at 1 month. Change of scores on UPDRS part III, HRSD, and PSQI persisted for 3 months after rTMS intervention. The beneficial effect on cognitive performance assessed by MoCA was maintained for at least 6 months in the follow-up. No significant changes were observed in the group with sham rTMS. Conclusions. Low-frequency rTMS of right DLPFC could be a potential selection in managing motor and nonmotor symptoms in PD. |
| format | Article |
| id | doaj-art-5a1349fbd6e340ea93c66f15c6f502b4 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-5a1349fbd6e340ea93c66f15c6f502b42025-02-03T06:43:45ZengWileyParkinson's Disease2090-80832042-00802020-01-01202010.1155/2020/72954147295414Low-Frequency Repetitive Transcranial Magnetic Stimulation over Right Dorsolateral Prefrontal Cortex in Parkinson’s DiseaseSheng Zhuang0Fu-Yu Wang1Xin Gu2Jia-Jing Wu3Cheng-Jie Mao4Hao Gui5Jing Chen6Chun-Feng Liu7Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Neurology, Suqian First Hospital, Suqian, ChinaDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaBackground. Repetitive transcranial magnetic stimulation (rTMS) is a promising therapeutic tool for Parkinson’s disease (PD), and many stimulation targets have been implicated. We aim to explore whether low-frequency rTMS over the right dorsolateral prefrontal cortex (DLPFC) improves motor and nonmotor symptoms of individuals with PD. Methods. We conducted a randomized, single-blind, sham-controlled parallel trial to compare the effect of 10 consecutive daily sessions of 1 Hz rTMS over right DLPFC on individuals with idiopathic PD between active and sham rTMS group. Primary outcomes were changes in Unified Parkinson’s Disease Rating Scale (UPDRS) part III and Nonmotor Symptom Questionnaire (NMSQ). Secondary outcomes were changes in UPDRS total score, Hamilton Rating Scale for Depression (HRSD), Pittsburgh Sleep Quality Index (PSQI), and Montreal Cognitive Assessment (MoCA). Assessments were completed at baseline, after treatment, and at 1 month, 3 months, and 6 months after treatment. Results. A total of 33 participants with PD were randomized. All participants completed the study and no severe adverse effect was noticed. Compared to baseline, active rTMS showed significant improvements in UPDRS part III and NMSQ at 1 month. Change of scores on UPDRS part III, HRSD, and PSQI persisted for 3 months after rTMS intervention. The beneficial effect on cognitive performance assessed by MoCA was maintained for at least 6 months in the follow-up. No significant changes were observed in the group with sham rTMS. Conclusions. Low-frequency rTMS of right DLPFC could be a potential selection in managing motor and nonmotor symptoms in PD.http://dx.doi.org/10.1155/2020/7295414 |
| spellingShingle | Sheng Zhuang Fu-Yu Wang Xin Gu Jia-Jing Wu Cheng-Jie Mao Hao Gui Jing Chen Chun-Feng Liu Low-Frequency Repetitive Transcranial Magnetic Stimulation over Right Dorsolateral Prefrontal Cortex in Parkinson’s Disease Parkinson's Disease |
| title | Low-Frequency Repetitive Transcranial Magnetic Stimulation over Right Dorsolateral Prefrontal Cortex in Parkinson’s Disease |
| title_full | Low-Frequency Repetitive Transcranial Magnetic Stimulation over Right Dorsolateral Prefrontal Cortex in Parkinson’s Disease |
| title_fullStr | Low-Frequency Repetitive Transcranial Magnetic Stimulation over Right Dorsolateral Prefrontal Cortex in Parkinson’s Disease |
| title_full_unstemmed | Low-Frequency Repetitive Transcranial Magnetic Stimulation over Right Dorsolateral Prefrontal Cortex in Parkinson’s Disease |
| title_short | Low-Frequency Repetitive Transcranial Magnetic Stimulation over Right Dorsolateral Prefrontal Cortex in Parkinson’s Disease |
| title_sort | low frequency repetitive transcranial magnetic stimulation over right dorsolateral prefrontal cortex in parkinson s disease |
| url | http://dx.doi.org/10.1155/2020/7295414 |
| work_keys_str_mv | AT shengzhuang lowfrequencyrepetitivetranscranialmagneticstimulationoverrightdorsolateralprefrontalcortexinparkinsonsdisease AT fuyuwang lowfrequencyrepetitivetranscranialmagneticstimulationoverrightdorsolateralprefrontalcortexinparkinsonsdisease AT xingu lowfrequencyrepetitivetranscranialmagneticstimulationoverrightdorsolateralprefrontalcortexinparkinsonsdisease AT jiajingwu lowfrequencyrepetitivetranscranialmagneticstimulationoverrightdorsolateralprefrontalcortexinparkinsonsdisease AT chengjiemao lowfrequencyrepetitivetranscranialmagneticstimulationoverrightdorsolateralprefrontalcortexinparkinsonsdisease AT haogui lowfrequencyrepetitivetranscranialmagneticstimulationoverrightdorsolateralprefrontalcortexinparkinsonsdisease AT jingchen lowfrequencyrepetitivetranscranialmagneticstimulationoverrightdorsolateralprefrontalcortexinparkinsonsdisease AT chunfengliu lowfrequencyrepetitivetranscranialmagneticstimulationoverrightdorsolateralprefrontalcortexinparkinsonsdisease |