Nonfunctioning Pituitary Adenoma That Changed to a Functional Gonadotropinoma
Objective. Pituitary adenomas can be classified as clinically functional or silent. Depending on the reviewed literature, these are the first or second place in frequency of the total pituitary adenomas. Even rarer is the presence of a functional gonadotropinoma since only very few case reports exis...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/5027859 |
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| author | Gerson Geovany Andino-Ríos Lesly Portocarrero-Ortiz Carlos Rojas-Guerrero Alejandro Terrones-Lozano Alma Ortiz-Plata Alfredo Adolfo Reza-Albarrán |
| author_facet | Gerson Geovany Andino-Ríos Lesly Portocarrero-Ortiz Carlos Rojas-Guerrero Alejandro Terrones-Lozano Alma Ortiz-Plata Alfredo Adolfo Reza-Albarrán |
| author_sort | Gerson Geovany Andino-Ríos |
| collection | DOAJ |
| description | Objective. Pituitary adenomas can be classified as clinically functional or silent. Depending on the reviewed literature, these are the first or second place in frequency of the total pituitary adenomas. Even rarer is the presence of a functional gonadotropinoma since only very few case reports exist to date. The conversion of a clinically silent to functional pituitary adenoma is extraordinarily rare; the mechanisms that explain these phenomena are unknown or not fully understood. Methods. We report the case of a woman who initially had a nonfunctional gonadotropinoma and in the course of her medical condition showed biochemical changes in her hormonal pituitary profile compatible with a functional gonadotropinoma. Results. We considered that the patient had a functional gonadotropinoma due to the hyperestrogenemia in the context of secondary amenorrhea, resolving the hyperestrogenemia after almost complete resection of the tumor. Conclusion. It is necessary to point out from a clinical and/or biochemical point of view the change in functionality that a nonfunctional pituitary adenoma may have. In the case of our patient, the suspicion of this change in functionality became evident when we found an increase in the FSH/LH ratio and a progressive increase in serum estradiol concentrations when the patient had amenorrhea. |
| format | Article |
| id | doaj-art-5a1107d894124826bd460a46f8694b83 |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-5a1107d894124826bd460a46f8694b832025-02-03T01:04:49ZengWileyCase Reports in Endocrinology2090-65012090-651X2018-01-01201810.1155/2018/50278595027859Nonfunctioning Pituitary Adenoma That Changed to a Functional GonadotropinomaGerson Geovany Andino-Ríos0Lesly Portocarrero-Ortiz1Carlos Rojas-Guerrero2Alejandro Terrones-Lozano3Alma Ortiz-Plata4Alfredo Adolfo Reza-Albarrán5Neuroendocrinology Department, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México, MexicoNeuroendocrinology Department, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México, MexicoNeuroendocrinology Department, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México, MexicoNeuroendocrinology Department, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México, MexicoExperimental Neuropathology Laboratory, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México, MexicoEndocrinology and Metabolism Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, MexicoObjective. Pituitary adenomas can be classified as clinically functional or silent. Depending on the reviewed literature, these are the first or second place in frequency of the total pituitary adenomas. Even rarer is the presence of a functional gonadotropinoma since only very few case reports exist to date. The conversion of a clinically silent to functional pituitary adenoma is extraordinarily rare; the mechanisms that explain these phenomena are unknown or not fully understood. Methods. We report the case of a woman who initially had a nonfunctional gonadotropinoma and in the course of her medical condition showed biochemical changes in her hormonal pituitary profile compatible with a functional gonadotropinoma. Results. We considered that the patient had a functional gonadotropinoma due to the hyperestrogenemia in the context of secondary amenorrhea, resolving the hyperestrogenemia after almost complete resection of the tumor. Conclusion. It is necessary to point out from a clinical and/or biochemical point of view the change in functionality that a nonfunctional pituitary adenoma may have. In the case of our patient, the suspicion of this change in functionality became evident when we found an increase in the FSH/LH ratio and a progressive increase in serum estradiol concentrations when the patient had amenorrhea.http://dx.doi.org/10.1155/2018/5027859 |
| spellingShingle | Gerson Geovany Andino-Ríos Lesly Portocarrero-Ortiz Carlos Rojas-Guerrero Alejandro Terrones-Lozano Alma Ortiz-Plata Alfredo Adolfo Reza-Albarrán Nonfunctioning Pituitary Adenoma That Changed to a Functional Gonadotropinoma Case Reports in Endocrinology |
| title | Nonfunctioning Pituitary Adenoma That Changed to a Functional Gonadotropinoma |
| title_full | Nonfunctioning Pituitary Adenoma That Changed to a Functional Gonadotropinoma |
| title_fullStr | Nonfunctioning Pituitary Adenoma That Changed to a Functional Gonadotropinoma |
| title_full_unstemmed | Nonfunctioning Pituitary Adenoma That Changed to a Functional Gonadotropinoma |
| title_short | Nonfunctioning Pituitary Adenoma That Changed to a Functional Gonadotropinoma |
| title_sort | nonfunctioning pituitary adenoma that changed to a functional gonadotropinoma |
| url | http://dx.doi.org/10.1155/2018/5027859 |
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