ESM-Ezy: a deep learning strategy for the mining of novel multicopper oxidases with superior properties

Abstract The UniProt database is a valuable resource for biocatalyst discovery, yet predicting enzymatic functions remains challenging, especially for low-similarity sequences. Identifying superior enzymes with enhanced catalytic properties is even harder. To overcome these challenges, we develop ES...

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Bibliographic Details
Main Authors: Hui Qian, Yuxuan Wang, Xibin Zhou, Tao Gu, Hui Wang, Hao Lyu, Zhikai Li, Xiuxu Li, Huan Zhou, Chengchen Guo, Fajie Yuan, Yajie Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58521-y
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