Laryngeal Carcinoma Characteristics Associated with Positive Margins and Endoscopic Understaging
<b>Background/Objectives</b>: The study aims to analyse the factors associated with positive margins and endoscopic understaging in laryngeal carcinoma. It also aims to assess the diagnostic accuracy of Narrow Band Imaging (NBI) in comparison to White Light Endoscopy (WLE) and other diag...
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MDPI AG
2025-01-01
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| Online Access: | https://www.mdpi.com/2075-4418/15/2/150 |
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| author | Nia Labaš Andro Košec Mirta Peček Tomislav Gregurić Siniša Stevanović |
| author_facet | Nia Labaš Andro Košec Mirta Peček Tomislav Gregurić Siniša Stevanović |
| author_sort | Nia Labaš |
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| description | <b>Background/Objectives</b>: The study aims to analyse the factors associated with positive margins and endoscopic understaging in laryngeal carcinoma. It also aims to assess the diagnostic accuracy of Narrow Band Imaging (NBI) in comparison to White Light Endoscopy (WLE) and other diagnostic methods. <b>Methods</b>: In this retrospective comparative cohort analysis, 206 patients who underwent endoscopic laser surgery for T1 and T2a glottic squamous cell carcinoma between 1 January 2016 and 30 April 2023 were included. The data were collected from endoscopy, CT, histopathology, and NBI images. Statistical analysis was performed and associations between variables were analysed using binary logistic regression and receiver operating characteristic analysis. <b>Results</b>: The types of cordectomy performed included type III (51 patients), type IV (40 patients), and type VI (23 patients). Positive margins were found in 14.01% of patients, with significant correlations observed between positive margins and bilateral laryngeal carcinoma, right-sided laryngeal carcinoma, higher clinical and histopathologic T categories, and higher NBI grade. Endoscopic understaging versus histopathologic T category correlated with various factors, including cordectomy type, tumour size, and clinical T category. The NBI findings correlated with positive margins but did not correlate with endoscopic understaging. <b>Conclusions</b>: The study highlights several clinical and pathological factors associated with positive margins and endoscopic understaging in laryngeal carcinoma. NBI demonstrated high diagnostic accuracy, correlating with histopathological results and serving as an independent predictive factor for positive margins. Recognizing these factors is crucial for improving preoperative assessments, refining treatment strategies, and enhancing patient care. |
| format | Article |
| id | doaj-art-5a07d9cf83b548f09d37511ebb89fed8 |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-5a07d9cf83b548f09d37511ebb89fed82025-01-24T13:28:54ZengMDPI AGDiagnostics2075-44182025-01-0115215010.3390/diagnostics15020150Laryngeal Carcinoma Characteristics Associated with Positive Margins and Endoscopic UnderstagingNia Labaš0Andro Košec1Mirta Peček2Tomislav Gregurić3Siniša Stevanović4Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Center Sestre Milosrdnice, 10000 Zagreb, CroatiaDepartment of Otorhinolaryngology and Head and Neck Surgery, University Hospital Center Sestre Milosrdnice, 10000 Zagreb, CroatiaSchool of Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Clinical and Interventional Radiology, University Hospital Center Sestre Milosrdnice, 10000 Zagreb, CroatiaDepartment of Otorhinolaryngology and Head and Neck Surgery, University Hospital Center Sestre Milosrdnice, 10000 Zagreb, Croatia<b>Background/Objectives</b>: The study aims to analyse the factors associated with positive margins and endoscopic understaging in laryngeal carcinoma. It also aims to assess the diagnostic accuracy of Narrow Band Imaging (NBI) in comparison to White Light Endoscopy (WLE) and other diagnostic methods. <b>Methods</b>: In this retrospective comparative cohort analysis, 206 patients who underwent endoscopic laser surgery for T1 and T2a glottic squamous cell carcinoma between 1 January 2016 and 30 April 2023 were included. The data were collected from endoscopy, CT, histopathology, and NBI images. Statistical analysis was performed and associations between variables were analysed using binary logistic regression and receiver operating characteristic analysis. <b>Results</b>: The types of cordectomy performed included type III (51 patients), type IV (40 patients), and type VI (23 patients). Positive margins were found in 14.01% of patients, with significant correlations observed between positive margins and bilateral laryngeal carcinoma, right-sided laryngeal carcinoma, higher clinical and histopathologic T categories, and higher NBI grade. Endoscopic understaging versus histopathologic T category correlated with various factors, including cordectomy type, tumour size, and clinical T category. The NBI findings correlated with positive margins but did not correlate with endoscopic understaging. <b>Conclusions</b>: The study highlights several clinical and pathological factors associated with positive margins and endoscopic understaging in laryngeal carcinoma. NBI demonstrated high diagnostic accuracy, correlating with histopathological results and serving as an independent predictive factor for positive margins. Recognizing these factors is crucial for improving preoperative assessments, refining treatment strategies, and enhancing patient care.https://www.mdpi.com/2075-4418/15/2/150laryngeal carcinomanarrow band imagingunderstagingmargins |
| spellingShingle | Nia Labaš Andro Košec Mirta Peček Tomislav Gregurić Siniša Stevanović Laryngeal Carcinoma Characteristics Associated with Positive Margins and Endoscopic Understaging Diagnostics laryngeal carcinoma narrow band imaging understaging margins |
| title | Laryngeal Carcinoma Characteristics Associated with Positive Margins and Endoscopic Understaging |
| title_full | Laryngeal Carcinoma Characteristics Associated with Positive Margins and Endoscopic Understaging |
| title_fullStr | Laryngeal Carcinoma Characteristics Associated with Positive Margins and Endoscopic Understaging |
| title_full_unstemmed | Laryngeal Carcinoma Characteristics Associated with Positive Margins and Endoscopic Understaging |
| title_short | Laryngeal Carcinoma Characteristics Associated with Positive Margins and Endoscopic Understaging |
| title_sort | laryngeal carcinoma characteristics associated with positive margins and endoscopic understaging |
| topic | laryngeal carcinoma narrow band imaging understaging margins |
| url | https://www.mdpi.com/2075-4418/15/2/150 |
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