The Roles of Thyroid and Thyroid Hormone in Pancreas: Physiology and Pathology
It is widely accepted that thyroid hormones (THs), secreted from the thyroid, play important roles in energy metabolism. It is also known that THs also alter the functioning of other endocrine glands; however, their effects on pancreatic function have not yet been reviewed. One of the main functions...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/2861034 |
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| author | Chaoran Chen Zhenxing Xie Yingbin Shen Shu Fang Xia |
| author_facet | Chaoran Chen Zhenxing Xie Yingbin Shen Shu Fang Xia |
| author_sort | Chaoran Chen |
| collection | DOAJ |
| description | It is widely accepted that thyroid hormones (THs), secreted from the thyroid, play important roles in energy metabolism. It is also known that THs also alter the functioning of other endocrine glands; however, their effects on pancreatic function have not yet been reviewed. One of the main functions of the pancreas is insulin secretion, which is altered in diabetes. Diabetes, therefore, could be related to thyroid dysfunction. Earlier research on this subject focused on TH regulation of pancreas function (such as insulin secretion) or on insulin function through TH-mediated increase of energy metabolism. Afterwards, epidemiological investigations and animal test research found a link between autoimmune diseases, thyroid dysfunction, and pancreas pathology; however, the underlying mechanisms remain unknown. Furthermore, recent studies have shown that THs also play important roles in pancreas development and on islet pathology, both in diabetes and in pancreatic cancer. Therefore, an overview of the effects of thyroid and THs on pancreas physiology and pathology is presented. The topics contained in this review include a summary of the relationship between autoimmune thyroid dysfunction and autoimmune pancreas lesions and the effects of THs on pancreas development and pancreas pathology (diabetes and pancreatic cancer). |
| format | Article |
| id | doaj-art-59d35413af644218b9861398de5b89ae |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-59d35413af644218b9861398de5b89ae2025-02-03T06:05:03ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/28610342861034The Roles of Thyroid and Thyroid Hormone in Pancreas: Physiology and PathologyChaoran Chen0Zhenxing Xie1Yingbin Shen2Shu Fang Xia3Institute of Nursing and Health, College of Nursing and Health, Henan University, Kaifeng, ChinaSchool of Basic Medicine, Henan University, Jinming Avenue 475004, Henan, Kaifeng, ChinaDepartment of Food Science and Engineering, Jinan University, Guangzhou, ChinaWuxi School of Medicine, Jiangnan University, Wuxi, ChinaIt is widely accepted that thyroid hormones (THs), secreted from the thyroid, play important roles in energy metabolism. It is also known that THs also alter the functioning of other endocrine glands; however, their effects on pancreatic function have not yet been reviewed. One of the main functions of the pancreas is insulin secretion, which is altered in diabetes. Diabetes, therefore, could be related to thyroid dysfunction. Earlier research on this subject focused on TH regulation of pancreas function (such as insulin secretion) or on insulin function through TH-mediated increase of energy metabolism. Afterwards, epidemiological investigations and animal test research found a link between autoimmune diseases, thyroid dysfunction, and pancreas pathology; however, the underlying mechanisms remain unknown. Furthermore, recent studies have shown that THs also play important roles in pancreas development and on islet pathology, both in diabetes and in pancreatic cancer. Therefore, an overview of the effects of thyroid and THs on pancreas physiology and pathology is presented. The topics contained in this review include a summary of the relationship between autoimmune thyroid dysfunction and autoimmune pancreas lesions and the effects of THs on pancreas development and pancreas pathology (diabetes and pancreatic cancer).http://dx.doi.org/10.1155/2018/2861034 |
| spellingShingle | Chaoran Chen Zhenxing Xie Yingbin Shen Shu Fang Xia The Roles of Thyroid and Thyroid Hormone in Pancreas: Physiology and Pathology International Journal of Endocrinology |
| title | The Roles of Thyroid and Thyroid Hormone in Pancreas: Physiology and Pathology |
| title_full | The Roles of Thyroid and Thyroid Hormone in Pancreas: Physiology and Pathology |
| title_fullStr | The Roles of Thyroid and Thyroid Hormone in Pancreas: Physiology and Pathology |
| title_full_unstemmed | The Roles of Thyroid and Thyroid Hormone in Pancreas: Physiology and Pathology |
| title_short | The Roles of Thyroid and Thyroid Hormone in Pancreas: Physiology and Pathology |
| title_sort | roles of thyroid and thyroid hormone in pancreas physiology and pathology |
| url | http://dx.doi.org/10.1155/2018/2861034 |
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