IL-4 Deficiency Decreases Mortality but Increases Severity of Arthritis in Experimental Group B Streptococcus Infection
IL-4 is an anti-inflammatory cytokine that inhibits the onset and severity in different experimental arthritis models. Group B streptococci (GBS) have been recognized as an ever-growing cause of serious in...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2009-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2009/394021 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | IL-4 is an
anti-inflammatory cytokine that inhibits the
onset and severity in different experimental
arthritis models. Group B streptococci (GBS)
have been recognized as an ever-growing cause of
serious invasive infections in nonpregnant
adults. Septic arthritis is a clinical
manifestation of GBS infection. To investigate
the role of IL-4 in experimental GBS infection,
IL-4 deficient or competent mice were inoculated
with 1×107 GBS/mouse. Mortality, appearance of arthritis, GBS
growth in the organs, and local and systemic cytokine and
chemokine production were examined. IL-4–/– mice
showed lower mortality rates but increased severity of arthritis
and exhibited a lower microbial load in blood, kidneys, and joints
than wt mice. Increased local levels of IL-1 β, IL-6, TNF-α, MIP-1α, and MIP-2 accompanied the more severe arthritis in IL-4–/– mice. Our results suggest a detrimental role of IL-4 in GBS sepsis, whereas it plays a beneficial effect on GBS-induced arthritis. |
|---|---|
| ISSN: | 0962-9351 1466-1861 |