Cellular senescence: from homeostasis to pathological implications and therapeutic strategies
Cellular aging is a multifactorial and intricately regulated physiological process with profound implications. The interaction between cellular senescence and cancer is complex and multifaceted, senescence can both promote and inhibit tumor progression through various mechanisms. M6A methylation mod...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1534263/full |
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| author | Chunhong Li Yixiao Yuan YingDong Jia Qiang Zhou Qiang Wang Xiulin Jiang |
| author_facet | Chunhong Li Yixiao Yuan YingDong Jia Qiang Zhou Qiang Wang Xiulin Jiang |
| author_sort | Chunhong Li |
| collection | DOAJ |
| description | Cellular aging is a multifactorial and intricately regulated physiological process with profound implications. The interaction between cellular senescence and cancer is complex and multifaceted, senescence can both promote and inhibit tumor progression through various mechanisms. M6A methylation modification regulates the aging process of cells and tissues by modulating senescence-related genes. In this review, we comprehensively discuss the characteristics of cellular senescence, the signaling pathways regulating senescence, the biomarkers of senescence, and the mechanisms of anti-senescence drugs. Notably, this review also delves into the complex interactions between senescence and cancer, emphasizing the dual role of the senescent microenvironment in tumor initiation, progression, and treatment. Finally, we thoroughly explore the function and mechanism of m6A methylation modification in cellular senescence, revealing its critical role in regulating gene expression and maintaining cellular homeostasis. In conclusion, this review provides a comprehensive perspective on the molecular mechanisms and biological significance of cellular senescence and offers new insights for the development of anti-senescence strategies. |
| format | Article |
| id | doaj-art-59b8cdb54971482bbda54e357f34ea34 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-59b8cdb54971482bbda54e357f34ea342025-02-03T05:11:53ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-02-011610.3389/fimmu.2025.15342631534263Cellular senescence: from homeostasis to pathological implications and therapeutic strategiesChunhong Li0Yixiao Yuan1YingDong Jia2Qiang Zhou3Qiang Wang4Xiulin Jiang5Department of Oncology, Suining Central Hospital, Suining, Sichuan, ChinaDepartment of Medicine, Health Cancer Center, University of Florida, Gainesville, FL, United StatesGastrointestinal Surgical Unit, Suining Central Hospital, Suining, Sichuan, ChinaDepartment of Oncology, Suining Central Hospital, Suining, Sichuan, ChinaGastrointestinal Surgical Unit, Suining Central Hospital, Suining, Sichuan, ChinaDepartment of Medicine, Health Cancer Center, University of Florida, Gainesville, FL, United StatesCellular aging is a multifactorial and intricately regulated physiological process with profound implications. The interaction between cellular senescence and cancer is complex and multifaceted, senescence can both promote and inhibit tumor progression through various mechanisms. M6A methylation modification regulates the aging process of cells and tissues by modulating senescence-related genes. In this review, we comprehensively discuss the characteristics of cellular senescence, the signaling pathways regulating senescence, the biomarkers of senescence, and the mechanisms of anti-senescence drugs. Notably, this review also delves into the complex interactions between senescence and cancer, emphasizing the dual role of the senescent microenvironment in tumor initiation, progression, and treatment. Finally, we thoroughly explore the function and mechanism of m6A methylation modification in cellular senescence, revealing its critical role in regulating gene expression and maintaining cellular homeostasis. In conclusion, this review provides a comprehensive perspective on the molecular mechanisms and biological significance of cellular senescence and offers new insights for the development of anti-senescence strategies.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1534263/fullcellular senescencecancerm6A RNA methylationaginglongevityinflammation |
| spellingShingle | Chunhong Li Yixiao Yuan YingDong Jia Qiang Zhou Qiang Wang Xiulin Jiang Cellular senescence: from homeostasis to pathological implications and therapeutic strategies Frontiers in Immunology cellular senescence cancer m6A RNA methylation aging longevity inflammation |
| title | Cellular senescence: from homeostasis to pathological implications and therapeutic strategies |
| title_full | Cellular senescence: from homeostasis to pathological implications and therapeutic strategies |
| title_fullStr | Cellular senescence: from homeostasis to pathological implications and therapeutic strategies |
| title_full_unstemmed | Cellular senescence: from homeostasis to pathological implications and therapeutic strategies |
| title_short | Cellular senescence: from homeostasis to pathological implications and therapeutic strategies |
| title_sort | cellular senescence from homeostasis to pathological implications and therapeutic strategies |
| topic | cellular senescence cancer m6A RNA methylation aging longevity inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1534263/full |
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