Asymmetric Cell Kinetics Genes: The Key to Expansion of Adult Stem Cells in Culture
A singular challenge in stem cell research today is the expansion and propagation of functional adult stem cells. Unlike embryonic stem cells, which are immortal in culture, adult stem cells are notorious for the difficulty encountered when attempts are made to expand them in culture. One overlooked...
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| Format: | Article |
| Language: | English |
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Wiley
2002-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2002.869 |
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| _version_ | 1832545576958296064 |
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| author | James L. Sherley |
| author_facet | James L. Sherley |
| author_sort | James L. Sherley |
| collection | DOAJ |
| description | A singular challenge in stem cell research today is the expansion and propagation of functional adult stem cells. Unlike embryonic stem cells, which are immortal in culture, adult stem cells are notorious for the difficulty encountered when attempts are made to expand them in culture. One overlooked reason for this difficulty may be the inherent asymmetric cell kinetics of stem cells in postnatal somatic tissues. Senescence is the expected fate of a culture whose growth depends on adult stem cells that divide with asymmetric cell kinetics. Therefore, the bioengineering of strategies to expand adult stem cells in culture requires knowledge of cellular mechanisms that control asymmetric cell kinetics. The properties of several genes recently implicated to function in a cellular pathway(s) that regulates asymmetric cell kinetics are discussed. Understanding the function of these genes in asymmetric cell kinetics mechanisms may be the key that unlocks the adult stem cell expansion problem. |
| format | Article |
| id | doaj-art-59b375fa95884a0d8d1306817fbfa5dc |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2002-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-59b375fa95884a0d8d1306817fbfa5dc2025-02-03T07:25:18ZengWileyThe Scientific World Journal1537-744X2002-01-0121906192110.1100/tsw.2002.869Asymmetric Cell Kinetics Genes: The Key to Expansion of Adult Stem Cells in CultureJames L. Sherley0Biological Engineering Division Biotechnology Process Eng. Center Massachusetts Inst. of Technology, Cambridge, MA, USAA singular challenge in stem cell research today is the expansion and propagation of functional adult stem cells. Unlike embryonic stem cells, which are immortal in culture, adult stem cells are notorious for the difficulty encountered when attempts are made to expand them in culture. One overlooked reason for this difficulty may be the inherent asymmetric cell kinetics of stem cells in postnatal somatic tissues. Senescence is the expected fate of a culture whose growth depends on adult stem cells that divide with asymmetric cell kinetics. Therefore, the bioengineering of strategies to expand adult stem cells in culture requires knowledge of cellular mechanisms that control asymmetric cell kinetics. The properties of several genes recently implicated to function in a cellular pathway(s) that regulates asymmetric cell kinetics are discussed. Understanding the function of these genes in asymmetric cell kinetics mechanisms may be the key that unlocks the adult stem cell expansion problem.http://dx.doi.org/10.1100/tsw.2002.869 |
| spellingShingle | James L. Sherley Asymmetric Cell Kinetics Genes: The Key to Expansion of Adult Stem Cells in Culture The Scientific World Journal |
| title | Asymmetric Cell Kinetics Genes: The Key to Expansion of Adult Stem Cells in Culture |
| title_full | Asymmetric Cell Kinetics Genes: The Key to Expansion of Adult Stem Cells in Culture |
| title_fullStr | Asymmetric Cell Kinetics Genes: The Key to Expansion of Adult Stem Cells in Culture |
| title_full_unstemmed | Asymmetric Cell Kinetics Genes: The Key to Expansion of Adult Stem Cells in Culture |
| title_short | Asymmetric Cell Kinetics Genes: The Key to Expansion of Adult Stem Cells in Culture |
| title_sort | asymmetric cell kinetics genes the key to expansion of adult stem cells in culture |
| url | http://dx.doi.org/10.1100/tsw.2002.869 |
| work_keys_str_mv | AT jameslsherley asymmetriccellkineticsgenesthekeytoexpansionofadultstemcellsinculture |