Sedative and Hypnotic Activities of the Methanolic and Aqueous Extracts of Lavandula officinalis from Morocco
We evaluate the sedative and hypnotic activities of the methanolic and aqueous extract of Lavandula officinalis L. on central nervous system (CNS). In this study, the effect of the methanolic and aqueous extracts of this plant was investigated in a battery of behavioural models in mice. Stems and...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Advances in Pharmacological Sciences |
| Online Access: | http://dx.doi.org/10.1155/2012/270824 |
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| author | Rachad Alnamer Katim Alaoui El Houcine Bouidida Abdelaziz Benjouad Yahia Cherrah |
| author_facet | Rachad Alnamer Katim Alaoui El Houcine Bouidida Abdelaziz Benjouad Yahia Cherrah |
| author_sort | Rachad Alnamer |
| collection | DOAJ |
| description | We evaluate the sedative and hypnotic activities of the methanolic and aqueous extract of Lavandula officinalis L. on central nervous system (CNS). In this study, the effect of the methanolic and aqueous extracts of this plant was investigated in a battery of behavioural models in mice. Stems and flowers of Lavandula officinalis L. have several therapeutic applications in folk medicine in curing or managing a wide range of diseases, including insomnia. The methanolic extract produced significant sedative effect at the doses of 200, 400, and 600 mg/kg (by oral route), compared to reference substance diazepam (DZP), and an hypnotic effect at the doses of 800 and 1000 mg/kg while the treatment of mice with the aqueous extract at the doses of 200 and 400 mg/kg via oral pathway significantly reduced in both the reestablishment time and number of head dips during the traction and hole-board tests. In conclusion, these results suggest that the methanolic and aqueous extracts of Lavandula officinalis possess potent sedative and hypnotic activities, which supported its therapeutic use for insomnia. |
| format | Article |
| id | doaj-art-59b2ce575b6c4d62bd85b27435a8c9ac |
| institution | Kabale University |
| issn | 1687-6334 1687-6342 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological Sciences |
| spelling | doaj-art-59b2ce575b6c4d62bd85b27435a8c9ac2025-02-03T01:32:11ZengWileyAdvances in Pharmacological Sciences1687-63341687-63422012-01-01201210.1155/2012/270824270824Sedative and Hypnotic Activities of the Methanolic and Aqueous Extracts of Lavandula officinalis from MoroccoRachad Alnamer0Katim Alaoui1El Houcine Bouidida2Abdelaziz Benjouad3Yahia Cherrah4Laboratory of Genetic Immunology and Biochemistry, Department of Biology, Faculty of Science, Mohammed V Agdal University, BP 6203, Rabat Instituts, Agdal, Rabat, MoroccoLaboratory of Pharmacology and Toxicology, Department of Drugs Sciences, Faculty of Medicine and Pharmacy, Mohammed V Souissi University, ERTP, BP 6203, Rabat Instituts, Agdal, Rabat, MoroccoNational Laboratory of Drugs Controlled, BP 6203, Rabat Instituts, Agdal, Rabat, MoroccoLaboratory of Genetic Immunology and Biochemistry, Department of Biology, Faculty of Science, Mohammed V Agdal University, BP 6203, Rabat Instituts, Agdal, Rabat, MoroccoLaboratory of Pharmacology and Toxicology, Department of Drugs Sciences, Faculty of Medicine and Pharmacy, Mohammed V Souissi University, ERTP, BP 6203, Rabat Instituts, Agdal, Rabat, MoroccoWe evaluate the sedative and hypnotic activities of the methanolic and aqueous extract of Lavandula officinalis L. on central nervous system (CNS). In this study, the effect of the methanolic and aqueous extracts of this plant was investigated in a battery of behavioural models in mice. Stems and flowers of Lavandula officinalis L. have several therapeutic applications in folk medicine in curing or managing a wide range of diseases, including insomnia. The methanolic extract produced significant sedative effect at the doses of 200, 400, and 600 mg/kg (by oral route), compared to reference substance diazepam (DZP), and an hypnotic effect at the doses of 800 and 1000 mg/kg while the treatment of mice with the aqueous extract at the doses of 200 and 400 mg/kg via oral pathway significantly reduced in both the reestablishment time and number of head dips during the traction and hole-board tests. In conclusion, these results suggest that the methanolic and aqueous extracts of Lavandula officinalis possess potent sedative and hypnotic activities, which supported its therapeutic use for insomnia.http://dx.doi.org/10.1155/2012/270824 |
| spellingShingle | Rachad Alnamer Katim Alaoui El Houcine Bouidida Abdelaziz Benjouad Yahia Cherrah Sedative and Hypnotic Activities of the Methanolic and Aqueous Extracts of Lavandula officinalis from Morocco Advances in Pharmacological Sciences |
| title | Sedative and Hypnotic Activities of the Methanolic and Aqueous Extracts of Lavandula officinalis from Morocco |
| title_full | Sedative and Hypnotic Activities of the Methanolic and Aqueous Extracts of Lavandula officinalis from Morocco |
| title_fullStr | Sedative and Hypnotic Activities of the Methanolic and Aqueous Extracts of Lavandula officinalis from Morocco |
| title_full_unstemmed | Sedative and Hypnotic Activities of the Methanolic and Aqueous Extracts of Lavandula officinalis from Morocco |
| title_short | Sedative and Hypnotic Activities of the Methanolic and Aqueous Extracts of Lavandula officinalis from Morocco |
| title_sort | sedative and hypnotic activities of the methanolic and aqueous extracts of lavandula officinalis from morocco |
| url | http://dx.doi.org/10.1155/2012/270824 |
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