Is polymyositis a rare or over-diagnosed entity? A descriptive follow-up study of patients initially admitted in a tertiary center with the diagnosis of polymyositis
Objective: This study aimed to describe a significant sample of patients with an initial diagnosis early-stage polymyositis (PM) in who were reclassified to different diagnoses after new evaluations during follow-ups. Subjects and Methods: In a single-center descriptive study conducted from 2000 to...
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SAGE Publishing
2020-01-01
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| Series: | Indian Journal of Rheumatology |
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| Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=6;spage=180;epage=186;aulast=Olivo |
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| author | Pablo Arturo Olivo Pallo Matheus Santos Rodrigues Silva Fernando Henrique Carlos de Souza Samuel Katsuyuki Shinjo |
| author_facet | Pablo Arturo Olivo Pallo Matheus Santos Rodrigues Silva Fernando Henrique Carlos de Souza Samuel Katsuyuki Shinjo |
| author_sort | Pablo Arturo Olivo Pallo |
| collection | DOAJ |
| description | Objective: This study aimed to describe a significant sample of patients with an initial diagnosis early-stage polymyositis (PM) in who were reclassified to different diagnoses after new evaluations during follow-ups.
Subjects and Methods: In a single-center descriptive study conducted from 2000 to 2019, 108 patients with an initial presumptive diagnosis of PM were admitted to our tertiary center and were reevaluated during follow-up. Patients with promptly suspected or definite initial diagnoses of other autoimmune or hereditary myopathies were excluded.
Results: The mean age of the 108 patients when admitted initially into our center was 45.3 ± 15.4 years; they were predominantly female (70.4%) and Caucasian (81.5%). During a median follow-up period of 4.0 years and constant diagnostic reinvestigation, only 30 (27.7%) out of the 108 participants maintained the PM diagnosis, whereas the other patients were re-diagnosed with immune-mediated necrotizing myopathy (20.4%), inclusion body myositis (18.5%), muscular dystrophy 13.0% as (13.0%), antisynthetase syndrome (8.3%), metabolic myopathies (5.6%), and other muscle diseases (7.3%). The initial clinical and laboratory parameters were not distinguishable between the PM and reclassified patients. Twenty-two of 30 patients with PM continued follow-up in our service, all with clinical remission or complete clinical response, full recovery of muscle strength, and normalization of the serum levels for muscle enzymes.
Conclusions: Patients with PM should be reevaluated constantly, as PM can mimic other muscle diseases. Notably, only one-third of our large patient samples maintained diagnoses of PM until the end of the present study's data collection. |
| format | Article |
| id | doaj-art-59b082873bc74245a0bbb86c67fa2072 |
| institution | Kabale University |
| issn | 0973-3698 0973-3701 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Rheumatology |
| spelling | doaj-art-59b082873bc74245a0bbb86c67fa20722025-02-02T23:15:59ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012020-01-0115618018610.4103/injr.injr_111_20Is polymyositis a rare or over-diagnosed entity? A descriptive follow-up study of patients initially admitted in a tertiary center with the diagnosis of polymyositisPablo Arturo Olivo PalloMatheus Santos Rodrigues SilvaFernando Henrique Carlos de SouzaSamuel Katsuyuki ShinjoObjective: This study aimed to describe a significant sample of patients with an initial diagnosis early-stage polymyositis (PM) in who were reclassified to different diagnoses after new evaluations during follow-ups. Subjects and Methods: In a single-center descriptive study conducted from 2000 to 2019, 108 patients with an initial presumptive diagnosis of PM were admitted to our tertiary center and were reevaluated during follow-up. Patients with promptly suspected or definite initial diagnoses of other autoimmune or hereditary myopathies were excluded. Results: The mean age of the 108 patients when admitted initially into our center was 45.3 ± 15.4 years; they were predominantly female (70.4%) and Caucasian (81.5%). During a median follow-up period of 4.0 years and constant diagnostic reinvestigation, only 30 (27.7%) out of the 108 participants maintained the PM diagnosis, whereas the other patients were re-diagnosed with immune-mediated necrotizing myopathy (20.4%), inclusion body myositis (18.5%), muscular dystrophy 13.0% as (13.0%), antisynthetase syndrome (8.3%), metabolic myopathies (5.6%), and other muscle diseases (7.3%). The initial clinical and laboratory parameters were not distinguishable between the PM and reclassified patients. Twenty-two of 30 patients with PM continued follow-up in our service, all with clinical remission or complete clinical response, full recovery of muscle strength, and normalization of the serum levels for muscle enzymes. Conclusions: Patients with PM should be reevaluated constantly, as PM can mimic other muscle diseases. Notably, only one-third of our large patient samples maintained diagnoses of PM until the end of the present study's data collection.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=6;spage=180;epage=186;aulast=Olivodifferential diagnosesinflammatory myopathiesmyositispolymyositissystemic autoimmune myopathies |
| spellingShingle | Pablo Arturo Olivo Pallo Matheus Santos Rodrigues Silva Fernando Henrique Carlos de Souza Samuel Katsuyuki Shinjo Is polymyositis a rare or over-diagnosed entity? A descriptive follow-up study of patients initially admitted in a tertiary center with the diagnosis of polymyositis Indian Journal of Rheumatology differential diagnoses inflammatory myopathies myositis polymyositis systemic autoimmune myopathies |
| title | Is polymyositis a rare or over-diagnosed entity? A descriptive follow-up study of patients initially admitted in a tertiary center with the diagnosis of polymyositis |
| title_full | Is polymyositis a rare or over-diagnosed entity? A descriptive follow-up study of patients initially admitted in a tertiary center with the diagnosis of polymyositis |
| title_fullStr | Is polymyositis a rare or over-diagnosed entity? A descriptive follow-up study of patients initially admitted in a tertiary center with the diagnosis of polymyositis |
| title_full_unstemmed | Is polymyositis a rare or over-diagnosed entity? A descriptive follow-up study of patients initially admitted in a tertiary center with the diagnosis of polymyositis |
| title_short | Is polymyositis a rare or over-diagnosed entity? A descriptive follow-up study of patients initially admitted in a tertiary center with the diagnosis of polymyositis |
| title_sort | is polymyositis a rare or over diagnosed entity a descriptive follow up study of patients initially admitted in a tertiary center with the diagnosis of polymyositis |
| topic | differential diagnoses inflammatory myopathies myositis polymyositis systemic autoimmune myopathies |
| url | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=6;spage=180;epage=186;aulast=Olivo |
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