The unique association between estimated pulse wave velocity and the prevalence of diabetic kidney disease: a cross-sectional study
Abstract Objective Arteriosclerosis plays a significant role as one of the key pathological mechanisms underlying Diabetic Kidney Disease (DKD). The estimated Pulse Wave Velocity (ePWV) is used to assess arteriosclerosis, and is considered a potential clinical surrogate for pulse wave velocity. Ther...
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BMC
2025-01-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-024-04453-2 |
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| author | Shuwu Wei Xinyu Pan Yao Xiao Junping Wei |
| author_facet | Shuwu Wei Xinyu Pan Yao Xiao Junping Wei |
| author_sort | Shuwu Wei |
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| description | Abstract Objective Arteriosclerosis plays a significant role as one of the key pathological mechanisms underlying Diabetic Kidney Disease (DKD). The estimated Pulse Wave Velocity (ePWV) is used to assess arteriosclerosis, and is considered a potential clinical surrogate for pulse wave velocity. There are no studies on ePWV in relation to DKD. Our research represents the first embark to explore the relationship between ePWV and DKD. Methods In this cross-sectional analysis, we collected ePWV data from a cohort of 4,296 hospitalized Chinese patients. Multivariable-adjusted logistic regression models and restricted cubic spline (RCS) analysis were employed to examine the relationship between eGDR and the prevalence of DKD, UACR ≥ 30 mg/g, and eGFR < 60 mL/min per 1.73 m². Results After adjusting for confounding factors, each unit increase in ePWV was associated with a 23%, 21% and 25% increase in the prevalence of DKD, UACR ≥ 30 mg/g, and eGFR < 60 mL/min per 1.73 m² in T2DM participants, respectively. A J-shaped relationship was observed between ePWV and the prevalence of DKD and eGFR < 60 mL/min per 1.73 m², and a linear association between ePWV and the prevalence of UACR ≥ 30 mg/g. Conclusion ePWV is independently positively correlated with the prevalence of DKD. Integrating ePWV into routine clinical evaluations enable timely interventions and personalized management approaches. |
| format | Article |
| id | doaj-art-59a4735b059a4832b61057a70cf098b1 |
| institution | Kabale University |
| issn | 1471-2261 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-59a4735b059a4832b61057a70cf098b12025-01-26T12:14:19ZengBMCBMC Cardiovascular Disorders1471-22612025-01-012511810.1186/s12872-024-04453-2The unique association between estimated pulse wave velocity and the prevalence of diabetic kidney disease: a cross-sectional studyShuwu Wei0Xinyu Pan1Yao Xiao2Junping Wei3Department of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesDepartment of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesDepartment of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesDepartment of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesAbstract Objective Arteriosclerosis plays a significant role as one of the key pathological mechanisms underlying Diabetic Kidney Disease (DKD). The estimated Pulse Wave Velocity (ePWV) is used to assess arteriosclerosis, and is considered a potential clinical surrogate for pulse wave velocity. There are no studies on ePWV in relation to DKD. Our research represents the first embark to explore the relationship between ePWV and DKD. Methods In this cross-sectional analysis, we collected ePWV data from a cohort of 4,296 hospitalized Chinese patients. Multivariable-adjusted logistic regression models and restricted cubic spline (RCS) analysis were employed to examine the relationship between eGDR and the prevalence of DKD, UACR ≥ 30 mg/g, and eGFR < 60 mL/min per 1.73 m². Results After adjusting for confounding factors, each unit increase in ePWV was associated with a 23%, 21% and 25% increase in the prevalence of DKD, UACR ≥ 30 mg/g, and eGFR < 60 mL/min per 1.73 m² in T2DM participants, respectively. A J-shaped relationship was observed between ePWV and the prevalence of DKD and eGFR < 60 mL/min per 1.73 m², and a linear association between ePWV and the prevalence of UACR ≥ 30 mg/g. Conclusion ePWV is independently positively correlated with the prevalence of DKD. Integrating ePWV into routine clinical evaluations enable timely interventions and personalized management approaches.https://doi.org/10.1186/s12872-024-04453-2Estimated pulse wave velocityType 2 diabetes mellitusDiabetic kidney diseaseUrinary albumin-to-creatinine ratioEstimated glomerular filtration rate |
| spellingShingle | Shuwu Wei Xinyu Pan Yao Xiao Junping Wei The unique association between estimated pulse wave velocity and the prevalence of diabetic kidney disease: a cross-sectional study BMC Cardiovascular Disorders Estimated pulse wave velocity Type 2 diabetes mellitus Diabetic kidney disease Urinary albumin-to-creatinine ratio Estimated glomerular filtration rate |
| title | The unique association between estimated pulse wave velocity and the prevalence of diabetic kidney disease: a cross-sectional study |
| title_full | The unique association between estimated pulse wave velocity and the prevalence of diabetic kidney disease: a cross-sectional study |
| title_fullStr | The unique association between estimated pulse wave velocity and the prevalence of diabetic kidney disease: a cross-sectional study |
| title_full_unstemmed | The unique association between estimated pulse wave velocity and the prevalence of diabetic kidney disease: a cross-sectional study |
| title_short | The unique association between estimated pulse wave velocity and the prevalence of diabetic kidney disease: a cross-sectional study |
| title_sort | unique association between estimated pulse wave velocity and the prevalence of diabetic kidney disease a cross sectional study |
| topic | Estimated pulse wave velocity Type 2 diabetes mellitus Diabetic kidney disease Urinary albumin-to-creatinine ratio Estimated glomerular filtration rate |
| url | https://doi.org/10.1186/s12872-024-04453-2 |
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