Posterior Cord Syndrome and Trace Elements Deficiency as an Uncommon Presentation of Common Variable Immunodeficiency
Diarrhea is one of the most common symptoms in common variable immunodeficiency, but neurologic manifestations are rare. We presented a 50-year-old woman with recurrent diarrhea and severe weight loss that developed a posterior cord syndrome. Endoscopy found a duodenal villous blunting, intraepithel...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2017/9870305 |
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| author | Yuri Silva Macedo Ananda dos Santos Mota Priscila Morais Monteiro Angela Cristina Gouvêa Carvalho Barbara Fernandes Diniz Pedro Gemal Lanzieri Ricardo Carneiro Ramos Luis Otavio Mocarzel Ronaldo Altenburg Gismondi |
| author_facet | Yuri Silva Macedo Ananda dos Santos Mota Priscila Morais Monteiro Angela Cristina Gouvêa Carvalho Barbara Fernandes Diniz Pedro Gemal Lanzieri Ricardo Carneiro Ramos Luis Otavio Mocarzel Ronaldo Altenburg Gismondi |
| author_sort | Yuri Silva Macedo |
| collection | DOAJ |
| description | Diarrhea is one of the most common symptoms in common variable immunodeficiency, but neurologic manifestations are rare. We presented a 50-year-old woman with recurrent diarrhea and severe weight loss that developed a posterior cord syndrome. Endoscopy found a duodenal villous blunting, intraepithelial lymphocytosis, and lack of plasma cells and magnetic resonance imaging of the spine was normal. Laboratory assays confirmed common variable immunodeficiency syndrome and showed low levels of trace elements (copper and zinc). Treatment was initiated with parenteral replacement of trace elements and intravenous human immunoglobulin and the patient improved clinically. In conclusion, physicians must be aware that gastrointestinal and neurologic disorders may be related to each other and remember to request trace elements laboratory assessment. |
| format | Article |
| id | doaj-art-599fa9691d574714b1df027773b2d5e4 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-599fa9691d574714b1df027773b2d5e42025-02-03T07:24:44ZengWileyCase Reports in Medicine1687-96271687-96352017-01-01201710.1155/2017/98703059870305Posterior Cord Syndrome and Trace Elements Deficiency as an Uncommon Presentation of Common Variable ImmunodeficiencyYuri Silva Macedo0Ananda dos Santos Mota1Priscila Morais Monteiro2Angela Cristina Gouvêa Carvalho3Barbara Fernandes Diniz4Pedro Gemal Lanzieri5Ricardo Carneiro Ramos6Luis Otavio Mocarzel7Ronaldo Altenburg Gismondi8Department of Clinical Medicine, Hospital Universitário Antônio Pedro (HUAP), Universidade Federal Fluminense (UFF), Rua Marquês de Paraná 303, 7° Andar, Centro, 24033-90 Niterói, RJ, BrazilDepartment of Clinical Medicine, Hospital Universitário Antônio Pedro (HUAP), Universidade Federal Fluminense (UFF), Rua Marquês de Paraná 303, 7° Andar, Centro, 24033-90 Niterói, RJ, BrazilDepartment of Clinical Medicine, Hospital Universitário Antônio Pedro (HUAP), Universidade Federal Fluminense (UFF), Rua Marquês de Paraná 303, 7° Andar, Centro, 24033-90 Niterói, RJ, BrazilDepartment of Clinical Medicine, Hospital Universitário Antônio Pedro (HUAP), Universidade Federal Fluminense (UFF), Rua Marquês de Paraná 303, 7° Andar, Centro, 24033-90 Niterói, RJ, BrazilDepartment of Clinical Medicine, Hospital Universitário Antônio Pedro (HUAP), Universidade Federal Fluminense (UFF), Rua Marquês de Paraná 303, 7° Andar, Centro, 24033-90 Niterói, RJ, BrazilDepartment of Clinical Medicine, Hospital Universitário Antônio Pedro (HUAP), Universidade Federal Fluminense (UFF), Rua Marquês de Paraná 303, 7° Andar, Centro, 24033-90 Niterói, RJ, BrazilDepartment of Clinical Medicine, Hospital Universitário Antônio Pedro (HUAP), Universidade Federal Fluminense (UFF), Rua Marquês de Paraná 303, 7° Andar, Centro, 24033-90 Niterói, RJ, BrazilDepartment of Clinical Medicine, Hospital Universitário Antônio Pedro (HUAP), Universidade Federal Fluminense (UFF), Rua Marquês de Paraná 303, 7° Andar, Centro, 24033-90 Niterói, RJ, BrazilDepartment of Clinical Medicine, Hospital Universitário Antônio Pedro (HUAP), Universidade Federal Fluminense (UFF), Rua Marquês de Paraná 303, 7° Andar, Centro, 24033-90 Niterói, RJ, BrazilDiarrhea is one of the most common symptoms in common variable immunodeficiency, but neurologic manifestations are rare. We presented a 50-year-old woman with recurrent diarrhea and severe weight loss that developed a posterior cord syndrome. Endoscopy found a duodenal villous blunting, intraepithelial lymphocytosis, and lack of plasma cells and magnetic resonance imaging of the spine was normal. Laboratory assays confirmed common variable immunodeficiency syndrome and showed low levels of trace elements (copper and zinc). Treatment was initiated with parenteral replacement of trace elements and intravenous human immunoglobulin and the patient improved clinically. In conclusion, physicians must be aware that gastrointestinal and neurologic disorders may be related to each other and remember to request trace elements laboratory assessment.http://dx.doi.org/10.1155/2017/9870305 |
| spellingShingle | Yuri Silva Macedo Ananda dos Santos Mota Priscila Morais Monteiro Angela Cristina Gouvêa Carvalho Barbara Fernandes Diniz Pedro Gemal Lanzieri Ricardo Carneiro Ramos Luis Otavio Mocarzel Ronaldo Altenburg Gismondi Posterior Cord Syndrome and Trace Elements Deficiency as an Uncommon Presentation of Common Variable Immunodeficiency Case Reports in Medicine |
| title | Posterior Cord Syndrome and Trace Elements Deficiency as an Uncommon Presentation of Common Variable Immunodeficiency |
| title_full | Posterior Cord Syndrome and Trace Elements Deficiency as an Uncommon Presentation of Common Variable Immunodeficiency |
| title_fullStr | Posterior Cord Syndrome and Trace Elements Deficiency as an Uncommon Presentation of Common Variable Immunodeficiency |
| title_full_unstemmed | Posterior Cord Syndrome and Trace Elements Deficiency as an Uncommon Presentation of Common Variable Immunodeficiency |
| title_short | Posterior Cord Syndrome and Trace Elements Deficiency as an Uncommon Presentation of Common Variable Immunodeficiency |
| title_sort | posterior cord syndrome and trace elements deficiency as an uncommon presentation of common variable immunodeficiency |
| url | http://dx.doi.org/10.1155/2017/9870305 |
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