Successful Resection of Isolated Para-Aortic Lymph Node Recurrence from Advanced Sigmoid Colon Cancer following 156 Courses of FOLFIRI Regimen
Isolated para-aortic lymph node (PLN) recurrence from colorectal cancer (CRC) is rare, with no currently validated treatments. Few reports have described the successful resection of isolated PLN involvement from CRC following chemotherapy. We report the case of a 63-year-old man who underwent sigmoi...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Case Reports in Surgery |
| Online Access: | http://dx.doi.org/10.1155/2016/4548798 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564533652094976 |
|---|---|
| author | Kaoru Takeshima Kazuo Yamafuji Atsunori Asami Hideo Baba Nobuhiko Okamoto Hidena Takahashi Chisato Takagi Kiyoshi Kubochi |
| author_facet | Kaoru Takeshima Kazuo Yamafuji Atsunori Asami Hideo Baba Nobuhiko Okamoto Hidena Takahashi Chisato Takagi Kiyoshi Kubochi |
| author_sort | Kaoru Takeshima |
| collection | DOAJ |
| description | Isolated para-aortic lymph node (PLN) recurrence from colorectal cancer (CRC) is rare, with no currently validated treatments. Few reports have described the successful resection of isolated PLN involvement from CRC following chemotherapy. We report the case of a 63-year-old man who underwent sigmoidectomy for sigmoid colon cancer at our hospital. Pathological examination demonstrated advanced sigmoid colon cancer with metastatic involvement in both of the tested PLNs. Palliative chemotherapy was initiated four weeks after surgical resection, with administration of the FOLFIRI regimen. Four years after the operation, computed tomography (CT) revealed an enlarged PLN below the left renal vein. As PLN enlarged to 15 mm in the minor axis on a CT scan in 2014 after receiving a total of 156 courses of the FOLFIRI regimen, we considered the enlarged PLN to represent an isolated metastasis. Accordingly, lymph node resection was performed with microscopically negative margins. The patient maintained a good quality of life without any side effects throughout the whole course of his treatment and remains disease-free at 24 months without chemotherapy after resection of the isolated PLN. Curative resection following chemotherapy may improve survival of carefully selected advanced CRC patients with locoregional recurrence, such as isolated PLN involvement. |
| format | Article |
| id | doaj-art-5991c5ccce064038bd83994494f42c55 |
| institution | Kabale University |
| issn | 2090-6900 2090-6919 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Surgery |
| spelling | doaj-art-5991c5ccce064038bd83994494f42c552025-02-03T01:10:48ZengWileyCase Reports in Surgery2090-69002090-69192016-01-01201610.1155/2016/45487984548798Successful Resection of Isolated Para-Aortic Lymph Node Recurrence from Advanced Sigmoid Colon Cancer following 156 Courses of FOLFIRI RegimenKaoru Takeshima0Kazuo Yamafuji1Atsunori Asami2Hideo Baba3Nobuhiko Okamoto4Hidena Takahashi5Chisato Takagi6Kiyoshi Kubochi7Department of Surgery, Saitama City Hospital, Saitama 336-0911, JapanDepartment of Surgery, Saitama City Hospital, Saitama 336-0911, JapanDepartment of Surgery, Saitama City Hospital, Saitama 336-0911, JapanDepartment of Surgery, Saitama City Hospital, Saitama 336-0911, JapanDepartment of Surgery, Saitama City Hospital, Saitama 336-0911, JapanDepartment of Surgery, Saitama City Hospital, Saitama 336-0911, JapanDepartment of Surgery, Saitama City Hospital, Saitama 336-0911, JapanDepartment of Surgery, Saitama City Hospital, Saitama 336-0911, JapanIsolated para-aortic lymph node (PLN) recurrence from colorectal cancer (CRC) is rare, with no currently validated treatments. Few reports have described the successful resection of isolated PLN involvement from CRC following chemotherapy. We report the case of a 63-year-old man who underwent sigmoidectomy for sigmoid colon cancer at our hospital. Pathological examination demonstrated advanced sigmoid colon cancer with metastatic involvement in both of the tested PLNs. Palliative chemotherapy was initiated four weeks after surgical resection, with administration of the FOLFIRI regimen. Four years after the operation, computed tomography (CT) revealed an enlarged PLN below the left renal vein. As PLN enlarged to 15 mm in the minor axis on a CT scan in 2014 after receiving a total of 156 courses of the FOLFIRI regimen, we considered the enlarged PLN to represent an isolated metastasis. Accordingly, lymph node resection was performed with microscopically negative margins. The patient maintained a good quality of life without any side effects throughout the whole course of his treatment and remains disease-free at 24 months without chemotherapy after resection of the isolated PLN. Curative resection following chemotherapy may improve survival of carefully selected advanced CRC patients with locoregional recurrence, such as isolated PLN involvement.http://dx.doi.org/10.1155/2016/4548798 |
| spellingShingle | Kaoru Takeshima Kazuo Yamafuji Atsunori Asami Hideo Baba Nobuhiko Okamoto Hidena Takahashi Chisato Takagi Kiyoshi Kubochi Successful Resection of Isolated Para-Aortic Lymph Node Recurrence from Advanced Sigmoid Colon Cancer following 156 Courses of FOLFIRI Regimen Case Reports in Surgery |
| title | Successful Resection of Isolated Para-Aortic Lymph Node Recurrence from Advanced Sigmoid Colon Cancer following 156 Courses of FOLFIRI Regimen |
| title_full | Successful Resection of Isolated Para-Aortic Lymph Node Recurrence from Advanced Sigmoid Colon Cancer following 156 Courses of FOLFIRI Regimen |
| title_fullStr | Successful Resection of Isolated Para-Aortic Lymph Node Recurrence from Advanced Sigmoid Colon Cancer following 156 Courses of FOLFIRI Regimen |
| title_full_unstemmed | Successful Resection of Isolated Para-Aortic Lymph Node Recurrence from Advanced Sigmoid Colon Cancer following 156 Courses of FOLFIRI Regimen |
| title_short | Successful Resection of Isolated Para-Aortic Lymph Node Recurrence from Advanced Sigmoid Colon Cancer following 156 Courses of FOLFIRI Regimen |
| title_sort | successful resection of isolated para aortic lymph node recurrence from advanced sigmoid colon cancer following 156 courses of folfiri regimen |
| url | http://dx.doi.org/10.1155/2016/4548798 |
| work_keys_str_mv | AT kaorutakeshima successfulresectionofisolatedparaaorticlymphnoderecurrencefromadvancedsigmoidcoloncancerfollowing156coursesoffolfiriregimen AT kazuoyamafuji successfulresectionofisolatedparaaorticlymphnoderecurrencefromadvancedsigmoidcoloncancerfollowing156coursesoffolfiriregimen AT atsunoriasami successfulresectionofisolatedparaaorticlymphnoderecurrencefromadvancedsigmoidcoloncancerfollowing156coursesoffolfiriregimen AT hideobaba successfulresectionofisolatedparaaorticlymphnoderecurrencefromadvancedsigmoidcoloncancerfollowing156coursesoffolfiriregimen AT nobuhikookamoto successfulresectionofisolatedparaaorticlymphnoderecurrencefromadvancedsigmoidcoloncancerfollowing156coursesoffolfiriregimen AT hidenatakahashi successfulresectionofisolatedparaaorticlymphnoderecurrencefromadvancedsigmoidcoloncancerfollowing156coursesoffolfiriregimen AT chisatotakagi successfulresectionofisolatedparaaorticlymphnoderecurrencefromadvancedsigmoidcoloncancerfollowing156coursesoffolfiriregimen AT kiyoshikubochi successfulresectionofisolatedparaaorticlymphnoderecurrencefromadvancedsigmoidcoloncancerfollowing156coursesoffolfiriregimen |