Hemodynamic Evaluation of Nonselective β-Blockers in Patients with Cirrhosis and Refractory Ascites
Background. Nonselective β-blockers (NSBB) have been associated with increased incidence of paracentesis-induced circulatory dysfunction (PICD) and reduced survival in patients with cirrhosis and refractory ascites. Aim. To prospectively evaluate a hemodynamic response to NSBB in cirrhotics listed f...
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| Format: | Article |
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Wiley
2018-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2018/4098210 |
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| author | Alberto Ferrarese Valerie Tikhonoff Edoardo Casiglia Paolo Angeli Silvano Fasolato Diego Faggian Alberto Zanetto Giacomo Germani Francesco Paolo Russo Patrizia Burra Marco Senzolo |
| author_facet | Alberto Ferrarese Valerie Tikhonoff Edoardo Casiglia Paolo Angeli Silvano Fasolato Diego Faggian Alberto Zanetto Giacomo Germani Francesco Paolo Russo Patrizia Burra Marco Senzolo |
| author_sort | Alberto Ferrarese |
| collection | DOAJ |
| description | Background. Nonselective β-blockers (NSBB) have been associated with increased incidence of paracentesis-induced circulatory dysfunction (PICD) and reduced survival in patients with cirrhosis and refractory ascites. Aim. To prospectively evaluate a hemodynamic response to NSBB in cirrhotics listed for liver transplantation with refractory ascites undergoing large volume paracentesis (LVP). Methods. Patients with cirrhosis and refractory ascites, with an indication to start NSBB in primary prophylaxis for variceal bleeding, were enrolled. During two consecutive LVP, while being, respectively, off and on NSBB, cardiac output (CO), systemic vascular resistances (SVR), peripheral vascular resistances (PVR), and plasma renin activity (PRA) were noninvasively assessed. Results. Seventeen patients were enrolled, and 10 completed the study. Before NSBB introduction, SVR (1896 to 1348 dyn·s·cm−5; p=0.028) and PVR (47 to 30 mmHg·min·dl·ml−1; p=0.04) significantly decreased after LVP, while CO showed an increasing trend (3.9 to 4.5 l/m; p=0.06). After NSBB introduction, LVP was not associated with a significant increase in CO (3.4 to 3.8 l/m; p=0.13) nor with a significant decrease in SVR (2002 versus 1798 dyn·s·cm−5; p=0.1). Incidence of PICD was not increased after NSBB introduction. Conclusion. The negative inotropic effect of NSBB was counterbalanced by a smaller decrease of vascular resistances after LVP, probably due to splanchnic β2-blockade. This pilot study showed that NSBB introduction may be void of detrimental hemodynamic effects after LVP in cirrhotics with refractory ascites. |
| format | Article |
| id | doaj-art-5971043f674b454bb8ad8a113b866cb7 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
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| series | Gastroenterology Research and Practice |
| spelling | doaj-art-5971043f674b454bb8ad8a113b866cb72025-02-03T01:32:56ZengWileyGastroenterology Research and Practice1687-61211687-630X2018-01-01201810.1155/2018/40982104098210Hemodynamic Evaluation of Nonselective β-Blockers in Patients with Cirrhosis and Refractory AscitesAlberto Ferrarese0Valerie Tikhonoff1Edoardo Casiglia2Paolo Angeli3Silvano Fasolato4Diego Faggian5Alberto Zanetto6Giacomo Germani7Francesco Paolo Russo8Patrizia Burra9Marco Senzolo10Multivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, ItalyDepartment of Medicine, Padua University Hospital, Padua, ItalyDepartment of Medicine, Padua University Hospital, Padua, ItalyDepartment of Medicine, Padua University Hospital, Padua, ItalyDepartment of Medicine, Padua University Hospital, Padua, ItalyLaboratory Medicine, Department of Medical and Surgical Sciences, University of Padua, Padua, ItalyMultivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, ItalyMultivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, ItalyMultivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, ItalyMultivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, ItalyMultivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, ItalyBackground. Nonselective β-blockers (NSBB) have been associated with increased incidence of paracentesis-induced circulatory dysfunction (PICD) and reduced survival in patients with cirrhosis and refractory ascites. Aim. To prospectively evaluate a hemodynamic response to NSBB in cirrhotics listed for liver transplantation with refractory ascites undergoing large volume paracentesis (LVP). Methods. Patients with cirrhosis and refractory ascites, with an indication to start NSBB in primary prophylaxis for variceal bleeding, were enrolled. During two consecutive LVP, while being, respectively, off and on NSBB, cardiac output (CO), systemic vascular resistances (SVR), peripheral vascular resistances (PVR), and plasma renin activity (PRA) were noninvasively assessed. Results. Seventeen patients were enrolled, and 10 completed the study. Before NSBB introduction, SVR (1896 to 1348 dyn·s·cm−5; p=0.028) and PVR (47 to 30 mmHg·min·dl·ml−1; p=0.04) significantly decreased after LVP, while CO showed an increasing trend (3.9 to 4.5 l/m; p=0.06). After NSBB introduction, LVP was not associated with a significant increase in CO (3.4 to 3.8 l/m; p=0.13) nor with a significant decrease in SVR (2002 versus 1798 dyn·s·cm−5; p=0.1). Incidence of PICD was not increased after NSBB introduction. Conclusion. The negative inotropic effect of NSBB was counterbalanced by a smaller decrease of vascular resistances after LVP, probably due to splanchnic β2-blockade. This pilot study showed that NSBB introduction may be void of detrimental hemodynamic effects after LVP in cirrhotics with refractory ascites.http://dx.doi.org/10.1155/2018/4098210 |
| spellingShingle | Alberto Ferrarese Valerie Tikhonoff Edoardo Casiglia Paolo Angeli Silvano Fasolato Diego Faggian Alberto Zanetto Giacomo Germani Francesco Paolo Russo Patrizia Burra Marco Senzolo Hemodynamic Evaluation of Nonselective β-Blockers in Patients with Cirrhosis and Refractory Ascites Gastroenterology Research and Practice |
| title | Hemodynamic Evaluation of Nonselective β-Blockers in Patients with Cirrhosis and Refractory Ascites |
| title_full | Hemodynamic Evaluation of Nonselective β-Blockers in Patients with Cirrhosis and Refractory Ascites |
| title_fullStr | Hemodynamic Evaluation of Nonselective β-Blockers in Patients with Cirrhosis and Refractory Ascites |
| title_full_unstemmed | Hemodynamic Evaluation of Nonselective β-Blockers in Patients with Cirrhosis and Refractory Ascites |
| title_short | Hemodynamic Evaluation of Nonselective β-Blockers in Patients with Cirrhosis and Refractory Ascites |
| title_sort | hemodynamic evaluation of nonselective β blockers in patients with cirrhosis and refractory ascites |
| url | http://dx.doi.org/10.1155/2018/4098210 |
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