Nonalcoholic Fatty Liver Disease and Sarcopenia: Where Do We Stand?
The link between metabolic syndrome (MetS) and sarcopenia has not been extensively studied, but it is evident that they share several common features. Crucial mechanisms involved in sarcopenia-nonalcoholic fatty liver disease (NAFLD) interplay are based on effects of insulin resistance, chronic infl...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2020/8859719 |
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| author | Ivana Mikolasevic Tajana Pavic Tajana Filipec Kanizaj Darija Vranesic Bender Viktor Domislovic Zeljko Krznaric |
| author_facet | Ivana Mikolasevic Tajana Pavic Tajana Filipec Kanizaj Darija Vranesic Bender Viktor Domislovic Zeljko Krznaric |
| author_sort | Ivana Mikolasevic |
| collection | DOAJ |
| description | The link between metabolic syndrome (MetS) and sarcopenia has not been extensively studied, but it is evident that they share several common features. Crucial mechanisms involved in sarcopenia-nonalcoholic fatty liver disease (NAFLD) interplay are based on effects of insulin resistance, chronic inflammation, oxidative stress, and crosstalk between organs by secretion of cytokines (hepatokines, adipokines, and myokines). Currently, published studies confirm the association of sarcopenia with the degree of NAFLD defined by liver histology. However, prospective studies that will give us information regarding the causal effect of NAFLD and sarcopenia are still needed. Furthermore, there is a need for a patient-friendly, noninvasive, low-cost method for detection of loss of skeletal muscle mass, strength, and physical performance in the context of NAFLD. Moreover, potential treatment strategies such as physical exercise and nutritional supplementation, that are usually a part of management of sarcopenia, should also be investigated in NAFLD patients, especially given the fact that for now, we do not have a good treatment option for NAFLD. Therefore, future investigations should combine studies on NAFLD and sarcopenia in terms of physical activity and nutritional interventions such as vitamin D supplementation. This review aims to report recent evidence concerning the links between sarcopenia and NAFLD and methods to assess sarcopenia. |
| format | Article |
| id | doaj-art-59654e420c7649dcbb5b18c59205dd46 |
| institution | Kabale University |
| issn | 2291-2797 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-59654e420c7649dcbb5b18c59205dd462025-02-03T01:12:14ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27972020-01-01202010.1155/2020/88597198859719Nonalcoholic Fatty Liver Disease and Sarcopenia: Where Do We Stand?Ivana Mikolasevic0Tajana Pavic1Tajana Filipec Kanizaj2Darija Vranesic Bender3Viktor Domislovic4Zeljko Krznaric5Department of GastroenterologyDepartment of Internal MedicineDepartment of GastroenterologyUniversity Hospital Centre ZagrebDepartment for Gastroenterology and HepatologySchool of MedicineThe link between metabolic syndrome (MetS) and sarcopenia has not been extensively studied, but it is evident that they share several common features. Crucial mechanisms involved in sarcopenia-nonalcoholic fatty liver disease (NAFLD) interplay are based on effects of insulin resistance, chronic inflammation, oxidative stress, and crosstalk between organs by secretion of cytokines (hepatokines, adipokines, and myokines). Currently, published studies confirm the association of sarcopenia with the degree of NAFLD defined by liver histology. However, prospective studies that will give us information regarding the causal effect of NAFLD and sarcopenia are still needed. Furthermore, there is a need for a patient-friendly, noninvasive, low-cost method for detection of loss of skeletal muscle mass, strength, and physical performance in the context of NAFLD. Moreover, potential treatment strategies such as physical exercise and nutritional supplementation, that are usually a part of management of sarcopenia, should also be investigated in NAFLD patients, especially given the fact that for now, we do not have a good treatment option for NAFLD. Therefore, future investigations should combine studies on NAFLD and sarcopenia in terms of physical activity and nutritional interventions such as vitamin D supplementation. This review aims to report recent evidence concerning the links between sarcopenia and NAFLD and methods to assess sarcopenia.http://dx.doi.org/10.1155/2020/8859719 |
| spellingShingle | Ivana Mikolasevic Tajana Pavic Tajana Filipec Kanizaj Darija Vranesic Bender Viktor Domislovic Zeljko Krznaric Nonalcoholic Fatty Liver Disease and Sarcopenia: Where Do We Stand? Canadian Journal of Gastroenterology and Hepatology |
| title | Nonalcoholic Fatty Liver Disease and Sarcopenia: Where Do We Stand? |
| title_full | Nonalcoholic Fatty Liver Disease and Sarcopenia: Where Do We Stand? |
| title_fullStr | Nonalcoholic Fatty Liver Disease and Sarcopenia: Where Do We Stand? |
| title_full_unstemmed | Nonalcoholic Fatty Liver Disease and Sarcopenia: Where Do We Stand? |
| title_short | Nonalcoholic Fatty Liver Disease and Sarcopenia: Where Do We Stand? |
| title_sort | nonalcoholic fatty liver disease and sarcopenia where do we stand |
| url | http://dx.doi.org/10.1155/2020/8859719 |
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