4-Hydroxycinnamic acid attenuates neuronal cell death by inducing expression of plasma membrane redox enzymes and improving mitochondrial functions
Many approaches to neurodegenerative diseases that focus on amyloid-β clearance and gene therapy have not been successful. Some therapeutic applications focus on enhancing neuronal cell survival during the pathogenesis of neurodegenerative diseases, including mitochondrial dysfunction. Plasma membra...
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| Format: | Article |
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Tsinghua University Press
2023-07-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022002300 |
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| author | Sujin Park Yoon A Kim Jaewang Lee Hyunsoo Seo Sang-Jip Nam Dong-Gyu Jo Dong-Hoon Hyun |
| author_facet | Sujin Park Yoon A Kim Jaewang Lee Hyunsoo Seo Sang-Jip Nam Dong-Gyu Jo Dong-Hoon Hyun |
| author_sort | Sujin Park |
| collection | DOAJ |
| description | Many approaches to neurodegenerative diseases that focus on amyloid-β clearance and gene therapy have not been successful. Some therapeutic applications focus on enhancing neuronal cell survival during the pathogenesis of neurodegenerative diseases, including mitochondrial dysfunction. Plasma membrane (PM) redox enzymes are crucial in maintaining cellular physiology and redox homeostasis in response to mitochondrial dysfunction. Neurohormetic phytochemicals are known to induce the expression of detoxifying enzymes under stress conditions. In this study, mechanisms of neuroprotective effects of 4-hydroxycinnamic acid (HCA) were examined by analyzing cell survival, levels of abnormal proteins, and mitochondrial functions in two different neuronal cells. HCA protected two neuronal cells exhibited high expression of PM redox enzymes and the consequent increase in the NAD+/NADH ratio. Cells cultured with HCA showed delayed apoptosis and decreased oxidative/nitrative damage accompanied by decreased ROS production in the mitochondria. HCA increased the mitochondrial complexes I and II activities and ATP production. Also, HCA increased mitochondrial fusion and decreased mitochondrial fission. Overall, HCA maintains redox homeostasis and energy metabolism under oxidative/metabolic stress conditions. These findings suggest that HCA could be a promising therapeutic approach for neurodegenerative diseases. |
| format | Article |
| id | doaj-art-595cbb49ab3e4b289a642ebd2a69ccff |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-595cbb49ab3e4b289a642ebd2a69ccff2025-02-03T11:09:30ZengTsinghua University PressFood Science and Human Wellness2213-45302023-07-01124128712994-Hydroxycinnamic acid attenuates neuronal cell death by inducing expression of plasma membrane redox enzymes and improving mitochondrial functionsSujin Park0Yoon A Kim1Jaewang Lee2Hyunsoo Seo3Sang-Jip Nam4Dong-Gyu Jo5Dong-Hoon Hyun6Department of Life Science, Ewha Womans University, Seoul 03760, South KoreaDepartment of Life Science, Ewha Womans University, Seoul 03760, South KoreaDepartment of Life Science, Ewha Womans University, Seoul 03760, South KoreaDepartment of Life Science, Ewha Womans University, Seoul 03760, South KoreaDepartment of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, South KoreaSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, South KoreaDepartment of Life Science, Ewha Womans University, Seoul 03760, South Korea; Corresponding author at: Department of Life Science, Ewha Womans University, Seoul 03760, South Korea.Many approaches to neurodegenerative diseases that focus on amyloid-β clearance and gene therapy have not been successful. Some therapeutic applications focus on enhancing neuronal cell survival during the pathogenesis of neurodegenerative diseases, including mitochondrial dysfunction. Plasma membrane (PM) redox enzymes are crucial in maintaining cellular physiology and redox homeostasis in response to mitochondrial dysfunction. Neurohormetic phytochemicals are known to induce the expression of detoxifying enzymes under stress conditions. In this study, mechanisms of neuroprotective effects of 4-hydroxycinnamic acid (HCA) were examined by analyzing cell survival, levels of abnormal proteins, and mitochondrial functions in two different neuronal cells. HCA protected two neuronal cells exhibited high expression of PM redox enzymes and the consequent increase in the NAD+/NADH ratio. Cells cultured with HCA showed delayed apoptosis and decreased oxidative/nitrative damage accompanied by decreased ROS production in the mitochondria. HCA increased the mitochondrial complexes I and II activities and ATP production. Also, HCA increased mitochondrial fusion and decreased mitochondrial fission. Overall, HCA maintains redox homeostasis and energy metabolism under oxidative/metabolic stress conditions. These findings suggest that HCA could be a promising therapeutic approach for neurodegenerative diseases.http://www.sciencedirect.com/science/article/pii/S2213453022002300NADH-quinone oxidoreductase 1 (NQO1)Cytochrome b5 reductase4-Hydroxycinnamic acidNeuroprotectionImproved mitochondrial functions |
| spellingShingle | Sujin Park Yoon A Kim Jaewang Lee Hyunsoo Seo Sang-Jip Nam Dong-Gyu Jo Dong-Hoon Hyun 4-Hydroxycinnamic acid attenuates neuronal cell death by inducing expression of plasma membrane redox enzymes and improving mitochondrial functions Food Science and Human Wellness NADH-quinone oxidoreductase 1 (NQO1) Cytochrome b5 reductase 4-Hydroxycinnamic acid Neuroprotection Improved mitochondrial functions |
| title | 4-Hydroxycinnamic acid attenuates neuronal cell death by inducing expression of plasma membrane redox enzymes and improving mitochondrial functions |
| title_full | 4-Hydroxycinnamic acid attenuates neuronal cell death by inducing expression of plasma membrane redox enzymes and improving mitochondrial functions |
| title_fullStr | 4-Hydroxycinnamic acid attenuates neuronal cell death by inducing expression of plasma membrane redox enzymes and improving mitochondrial functions |
| title_full_unstemmed | 4-Hydroxycinnamic acid attenuates neuronal cell death by inducing expression of plasma membrane redox enzymes and improving mitochondrial functions |
| title_short | 4-Hydroxycinnamic acid attenuates neuronal cell death by inducing expression of plasma membrane redox enzymes and improving mitochondrial functions |
| title_sort | 4 hydroxycinnamic acid attenuates neuronal cell death by inducing expression of plasma membrane redox enzymes and improving mitochondrial functions |
| topic | NADH-quinone oxidoreductase 1 (NQO1) Cytochrome b5 reductase 4-Hydroxycinnamic acid Neuroprotection Improved mitochondrial functions |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022002300 |
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