The Role of the TGF-β Coreceptor Endoglin in Cancer
Endoglin (CD105) is an auxiliary membrane receptor of transforming growth factor beta (TGF-β) that interacts with type I and type II TGF-β receptors and modulates TGF-β signaling. Endoglin is overexpressed in the tumor-associated vascular endothelium, where it modulates angiogenesis. This feature ma...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2010.230 |
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| author | Eduardo Pérez-Gómez Gaelle del Castillo Juan Francisco Santibáñez Jose Miguel Lêpez-Novoa Carmelo Bernabéu Miguel Quintanilla |
| author_facet | Eduardo Pérez-Gómez Gaelle del Castillo Juan Francisco Santibáñez Jose Miguel Lêpez-Novoa Carmelo Bernabéu Miguel Quintanilla |
| author_sort | Eduardo Pérez-Gómez |
| collection | DOAJ |
| description | Endoglin (CD105) is an auxiliary membrane receptor of transforming growth factor beta (TGF-β) that interacts with type I and type II TGF-β receptors and modulates TGF-β signaling. Endoglin is overexpressed in the tumor-associated vascular endothelium, where it modulates angiogenesis. This feature makes endoglin a promising target for antiangiogenic cancer therapy. In addition, recent studies on human and experimental models of carcinogenesis point to an important tumor cell–autonomous role of endoglin by regulating proliferation, migration, invasion, and metastasis. These studies suggest that endoglin behaves as a suppressor of malignancy in experimental and human epithelial carcinogenesis, although it can also promote metastasis in other types of cancer. In this review, we evaluate the implication of endoglin in tumor development underlying studies developed in our laboratories in recent years. |
| format | Article |
| id | doaj-art-5957205d01a545718161703fe3924547 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-5957205d01a545718161703fe39245472025-02-03T01:33:18ZengWileyThe Scientific World Journal1537-744X2010-01-01102367238410.1100/tsw.2010.230The Role of the TGF-β Coreceptor Endoglin in CancerEduardo Pérez-Gómez0Gaelle del Castillo1Juan Francisco Santibáñez2Jose Miguel Lêpez-Novoa3Carmelo Bernabéu4Miguel Quintanilla5Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autênoma de Madrid, Madrid, SpainInstituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autênoma de Madrid, Madrid, SpainInstitute for Medical Research, University of Belgrado, Belgrado, SerbiaInstituto Reina Sofía de Investigaciên Nefrolêgica, Departamento de Fisiologia y Farmacología, Universidad de Salamanca, Salamanca, SpainCentro de Investigaciones Biológicas, CSIC, and CIBER de Enfermedades Raras (CIBERER), Madrid, SpainInstituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autênoma de Madrid, Madrid, SpainEndoglin (CD105) is an auxiliary membrane receptor of transforming growth factor beta (TGF-β) that interacts with type I and type II TGF-β receptors and modulates TGF-β signaling. Endoglin is overexpressed in the tumor-associated vascular endothelium, where it modulates angiogenesis. This feature makes endoglin a promising target for antiangiogenic cancer therapy. In addition, recent studies on human and experimental models of carcinogenesis point to an important tumor cell–autonomous role of endoglin by regulating proliferation, migration, invasion, and metastasis. These studies suggest that endoglin behaves as a suppressor of malignancy in experimental and human epithelial carcinogenesis, although it can also promote metastasis in other types of cancer. In this review, we evaluate the implication of endoglin in tumor development underlying studies developed in our laboratories in recent years.http://dx.doi.org/10.1100/tsw.2010.230 |
| spellingShingle | Eduardo Pérez-Gómez Gaelle del Castillo Juan Francisco Santibáñez Jose Miguel Lêpez-Novoa Carmelo Bernabéu Miguel Quintanilla The Role of the TGF-β Coreceptor Endoglin in Cancer The Scientific World Journal |
| title | The Role of the TGF-β Coreceptor Endoglin in Cancer |
| title_full | The Role of the TGF-β Coreceptor Endoglin in Cancer |
| title_fullStr | The Role of the TGF-β Coreceptor Endoglin in Cancer |
| title_full_unstemmed | The Role of the TGF-β Coreceptor Endoglin in Cancer |
| title_short | The Role of the TGF-β Coreceptor Endoglin in Cancer |
| title_sort | role of the tgf β coreceptor endoglin in cancer |
| url | http://dx.doi.org/10.1100/tsw.2010.230 |
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