Synthesis and Antimicrobial Activity of Some 3-(5-Phenyl-4,5-dihydro-1-substitutedpyrazol-3-yl) chromen-2-one
The title compounds were synthesized by condensation of 3-acetyl chromen-2-one with benzaldehyde in presence of alcoholic sodium hydroxide to get intermediate 3-(3-phenyl acryloyl) chromen-2-one, which were further treated with hydrazine hydrate to get 3-(5-phenyl-4,5-dihydro-1H-pyrazol-3-yl) chrome...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2010/184290 |
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| author | B. Lakshminarayanan V. Rajamanickam T. Subburaju L. A. Pradeep Rajkumar |
| author_facet | B. Lakshminarayanan V. Rajamanickam T. Subburaju L. A. Pradeep Rajkumar |
| author_sort | B. Lakshminarayanan |
| collection | DOAJ |
| description | The title compounds were synthesized by condensation of 3-acetyl chromen-2-one with benzaldehyde in presence of alcoholic sodium hydroxide to get intermediate 3-(3-phenyl acryloyl) chromen-2-one, which were further treated with hydrazine hydrate to get 3-(5-phenyl-4,5-dihydro-1H-pyrazol-3-yl) chromen-2-one. The latter were refluxed with various amino compounds and various aldehyde derivatives on water bath for 5 h to afford title compounds. All the compounds were tested for their antibacterial and antifungal activities by the cup plate method. |
| format | Article |
| id | doaj-art-59505c24ac7d4d23860b3049a8fa9a6d |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-59505c24ac7d4d23860b3049a8fa9a6d2025-02-03T01:28:44ZengWileyE-Journal of Chemistry0973-49452090-98102010-01-017238339010.1155/2010/184290Synthesis and Antimicrobial Activity of Some 3-(5-Phenyl-4,5-dihydro-1-substitutedpyrazol-3-yl) chromen-2-oneB. Lakshminarayanan0V. Rajamanickam1T. Subburaju2L. A. Pradeep Rajkumar3Karpagam College of Pharmacy, S.F.No:762, Othakkalmandapam, Coimbatore-641032, IndiaArulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnankoil-626190, IndiaKarpagam College of Pharmacy, S.F.No:762, Othakkalmandapam, Coimbatore-641032, IndiaKarpagam College of Pharmacy, S.F.No:762, Othakkalmandapam, Coimbatore-641032, IndiaThe title compounds were synthesized by condensation of 3-acetyl chromen-2-one with benzaldehyde in presence of alcoholic sodium hydroxide to get intermediate 3-(3-phenyl acryloyl) chromen-2-one, which were further treated with hydrazine hydrate to get 3-(5-phenyl-4,5-dihydro-1H-pyrazol-3-yl) chromen-2-one. The latter were refluxed with various amino compounds and various aldehyde derivatives on water bath for 5 h to afford title compounds. All the compounds were tested for their antibacterial and antifungal activities by the cup plate method.http://dx.doi.org/10.1155/2010/184290 |
| spellingShingle | B. Lakshminarayanan V. Rajamanickam T. Subburaju L. A. Pradeep Rajkumar Synthesis and Antimicrobial Activity of Some 3-(5-Phenyl-4,5-dihydro-1-substitutedpyrazol-3-yl) chromen-2-one E-Journal of Chemistry |
| title | Synthesis and Antimicrobial Activity of Some 3-(5-Phenyl-4,5-dihydro-1-substitutedpyrazol-3-yl) chromen-2-one |
| title_full | Synthesis and Antimicrobial Activity of Some 3-(5-Phenyl-4,5-dihydro-1-substitutedpyrazol-3-yl) chromen-2-one |
| title_fullStr | Synthesis and Antimicrobial Activity of Some 3-(5-Phenyl-4,5-dihydro-1-substitutedpyrazol-3-yl) chromen-2-one |
| title_full_unstemmed | Synthesis and Antimicrobial Activity of Some 3-(5-Phenyl-4,5-dihydro-1-substitutedpyrazol-3-yl) chromen-2-one |
| title_short | Synthesis and Antimicrobial Activity of Some 3-(5-Phenyl-4,5-dihydro-1-substitutedpyrazol-3-yl) chromen-2-one |
| title_sort | synthesis and antimicrobial activity of some 3 5 phenyl 4 5 dihydro 1 substitutedpyrazol 3 yl chromen 2 one |
| url | http://dx.doi.org/10.1155/2010/184290 |
| work_keys_str_mv | AT blakshminarayanan synthesisandantimicrobialactivityofsome35phenyl45dihydro1substitutedpyrazol3ylchromen2one AT vrajamanickam synthesisandantimicrobialactivityofsome35phenyl45dihydro1substitutedpyrazol3ylchromen2one AT tsubburaju synthesisandantimicrobialactivityofsome35phenyl45dihydro1substitutedpyrazol3ylchromen2one AT lapradeeprajkumar synthesisandantimicrobialactivityofsome35phenyl45dihydro1substitutedpyrazol3ylchromen2one |