Baicalin and Baicalein Inhibit Src Tyrosine Kinase and Production of IL-6
Flavonoids play an important role in the treatment of various diseases, as they are able to inhibit reactive oxygen species, which cause damage to cells and tissues which may lead to increased risk of inflammatory diseases. Baicalin and baicalein, two flavonoids found in the roots of Scutellaria bai...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2016/2510621 |
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| author | Dubravko Jelić Agnieszka D. Lower-Nedza Adelheid H. Brantner Biljana Blažeković Baolin Bian Jian Yang Karmen Brajša Sanda Vladimir-Knežević |
| author_facet | Dubravko Jelić Agnieszka D. Lower-Nedza Adelheid H. Brantner Biljana Blažeković Baolin Bian Jian Yang Karmen Brajša Sanda Vladimir-Knežević |
| author_sort | Dubravko Jelić |
| collection | DOAJ |
| description | Flavonoids play an important role in the treatment of various diseases, as they are able to inhibit reactive oxygen species, which cause damage to cells and tissues which may lead to increased risk of inflammatory diseases. Baicalin and baicalein, two flavonoids found in the roots of Scutellaria baicalensis, in the leaves of Thymus vulgaris and Oroxylum indicum, were tested for their anti-inflammatory activity as well as for their cytotoxicity. Thereby the two compounds were investigated on Src tyrosine kinase inhibition and inhibition of production of interleukin (IL-6) in lipopolysaccharide- (LPS-) stimulated THP-1 cells. Additionally, the THP-1 cell line was used for the determination of the cytotoxicity. Both baicalin and baicalein showed some anti-inflammatory properties, while baicalein turned out to be the more active compound with higher inhibitory activities on both Src tyrosine kinase and production of cytokine IL-6. Baicalin and baicalein showed no signs of cytotoxicity in the MTS cytotoxicity assay in THP-1 cells. |
| format | Article |
| id | doaj-art-594ee92c5b6c44419c6b5d93245eb550 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-594ee92c5b6c44419c6b5d93245eb5502025-02-03T01:22:29ZengWileyJournal of Chemistry2090-90632090-90712016-01-01201610.1155/2016/25106212510621Baicalin and Baicalein Inhibit Src Tyrosine Kinase and Production of IL-6Dubravko Jelić0Agnieszka D. Lower-Nedza1Adelheid H. Brantner2Biljana Blažeković3Baolin Bian4Jian Yang5Karmen Brajša6Sanda Vladimir-Knežević7Fidelta Ltd., Prilaz Baruna Filipovića 29, 10000 Zagreb, CroatiaInstitute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Universitaetsplatz 4/1, 8010 Graz, AustriaInstitute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Universitaetsplatz 4/1, 8010 Graz, AustriaDepartment of Pharmacognosy, Faculty of Pharmacy and Biochemistry, University of Zagreb, Marulićev Trg 20/II, 10000 Zagreb, CroatiaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, No. 16 Nanxiaojie, Dongzhimennei Avenue, Dongcheng District, Beijing 100700, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, No. 16 Nanxiaojie, Dongzhimennei Avenue, Dongcheng District, Beijing 100700, ChinaFidelta Ltd., Prilaz Baruna Filipovića 29, 10000 Zagreb, CroatiaDepartment of Pharmacognosy, Faculty of Pharmacy and Biochemistry, University of Zagreb, Marulićev Trg 20/II, 10000 Zagreb, CroatiaFlavonoids play an important role in the treatment of various diseases, as they are able to inhibit reactive oxygen species, which cause damage to cells and tissues which may lead to increased risk of inflammatory diseases. Baicalin and baicalein, two flavonoids found in the roots of Scutellaria baicalensis, in the leaves of Thymus vulgaris and Oroxylum indicum, were tested for their anti-inflammatory activity as well as for their cytotoxicity. Thereby the two compounds were investigated on Src tyrosine kinase inhibition and inhibition of production of interleukin (IL-6) in lipopolysaccharide- (LPS-) stimulated THP-1 cells. Additionally, the THP-1 cell line was used for the determination of the cytotoxicity. Both baicalin and baicalein showed some anti-inflammatory properties, while baicalein turned out to be the more active compound with higher inhibitory activities on both Src tyrosine kinase and production of cytokine IL-6. Baicalin and baicalein showed no signs of cytotoxicity in the MTS cytotoxicity assay in THP-1 cells.http://dx.doi.org/10.1155/2016/2510621 |
| spellingShingle | Dubravko Jelić Agnieszka D. Lower-Nedza Adelheid H. Brantner Biljana Blažeković Baolin Bian Jian Yang Karmen Brajša Sanda Vladimir-Knežević Baicalin and Baicalein Inhibit Src Tyrosine Kinase and Production of IL-6 Journal of Chemistry |
| title | Baicalin and Baicalein Inhibit Src Tyrosine Kinase and Production of IL-6 |
| title_full | Baicalin and Baicalein Inhibit Src Tyrosine Kinase and Production of IL-6 |
| title_fullStr | Baicalin and Baicalein Inhibit Src Tyrosine Kinase and Production of IL-6 |
| title_full_unstemmed | Baicalin and Baicalein Inhibit Src Tyrosine Kinase and Production of IL-6 |
| title_short | Baicalin and Baicalein Inhibit Src Tyrosine Kinase and Production of IL-6 |
| title_sort | baicalin and baicalein inhibit src tyrosine kinase and production of il 6 |
| url | http://dx.doi.org/10.1155/2016/2510621 |
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