Genomic exploration of the journey of Plasmodium vivax in Latin America.
Plasmodium vivax is the predominant malaria parasite in Latin America. Its colonization history in the region is rich and complex, and is still highly debated, especially about its origin(s). Our study employed cutting-edge population genomic techniques to analyze whole genome variation from 620 P....
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS Pathogens |
| Online Access: | https://doi.org/10.1371/journal.ppat.1012811 |
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| author | Margaux J M Lefebvre Fanny Degrugillier Céline Arnathau Gustavo A Fontecha Oscar Noya Sandrine Houzé Carlo Severini Bruno Pradines Antoine Berry Jean-François Trape Fabian E Sáenz Franck Prugnolle Michael C Fontaine Virginie Rougeron |
| author_facet | Margaux J M Lefebvre Fanny Degrugillier Céline Arnathau Gustavo A Fontecha Oscar Noya Sandrine Houzé Carlo Severini Bruno Pradines Antoine Berry Jean-François Trape Fabian E Sáenz Franck Prugnolle Michael C Fontaine Virginie Rougeron |
| author_sort | Margaux J M Lefebvre |
| collection | DOAJ |
| description | Plasmodium vivax is the predominant malaria parasite in Latin America. Its colonization history in the region is rich and complex, and is still highly debated, especially about its origin(s). Our study employed cutting-edge population genomic techniques to analyze whole genome variation from 620 P. vivax isolates, including 107 newly sequenced samples from West Africa, Middle East, and Latin America. This sampling represents nearly all potential source populations worldwide currently available. Analyses of the genetic structure, diversity, ancestry, coalescent-based inferences, including demographic scenario testing using Approximate Bayesian Computation, have revealed a more complex evolutionary history than previously envisioned. Indeed, our analyses suggest that the current American P. vivax populations predominantly stemmed from a now-extinct European lineage, with the potential contribution also from unsampled populations, most likely of West African origin. We also found evidence that P. vivax arrived in Latin America in multiple waves, initially during early European contact and later through post-colonial human migration waves in the late 19th-century. This study provides a fresh perspective on P. vivax's intricate evolutionary journey and brings insights into the possible contribution of West African P. vivax populations to the colonization history of Latin America. |
| format | Article |
| id | doaj-art-5943868ba65041ad8ad577e99b3a807a |
| institution | Kabale University |
| issn | 1553-7366 1553-7374 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj-art-5943868ba65041ad8ad577e99b3a807a2025-02-05T05:30:54ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742025-01-01211e101281110.1371/journal.ppat.1012811Genomic exploration of the journey of Plasmodium vivax in Latin America.Margaux J M LefebvreFanny DegrugillierCéline ArnathauGustavo A FontechaOscar NoyaSandrine HouzéCarlo SeveriniBruno PradinesAntoine BerryJean-François TrapeFabian E SáenzFranck PrugnolleMichael C FontaineVirginie RougeronPlasmodium vivax is the predominant malaria parasite in Latin America. Its colonization history in the region is rich and complex, and is still highly debated, especially about its origin(s). Our study employed cutting-edge population genomic techniques to analyze whole genome variation from 620 P. vivax isolates, including 107 newly sequenced samples from West Africa, Middle East, and Latin America. This sampling represents nearly all potential source populations worldwide currently available. Analyses of the genetic structure, diversity, ancestry, coalescent-based inferences, including demographic scenario testing using Approximate Bayesian Computation, have revealed a more complex evolutionary history than previously envisioned. Indeed, our analyses suggest that the current American P. vivax populations predominantly stemmed from a now-extinct European lineage, with the potential contribution also from unsampled populations, most likely of West African origin. We also found evidence that P. vivax arrived in Latin America in multiple waves, initially during early European contact and later through post-colonial human migration waves in the late 19th-century. This study provides a fresh perspective on P. vivax's intricate evolutionary journey and brings insights into the possible contribution of West African P. vivax populations to the colonization history of Latin America.https://doi.org/10.1371/journal.ppat.1012811 |
| spellingShingle | Margaux J M Lefebvre Fanny Degrugillier Céline Arnathau Gustavo A Fontecha Oscar Noya Sandrine Houzé Carlo Severini Bruno Pradines Antoine Berry Jean-François Trape Fabian E Sáenz Franck Prugnolle Michael C Fontaine Virginie Rougeron Genomic exploration of the journey of Plasmodium vivax in Latin America. PLoS Pathogens |
| title | Genomic exploration of the journey of Plasmodium vivax in Latin America. |
| title_full | Genomic exploration of the journey of Plasmodium vivax in Latin America. |
| title_fullStr | Genomic exploration of the journey of Plasmodium vivax in Latin America. |
| title_full_unstemmed | Genomic exploration of the journey of Plasmodium vivax in Latin America. |
| title_short | Genomic exploration of the journey of Plasmodium vivax in Latin America. |
| title_sort | genomic exploration of the journey of plasmodium vivax in latin america |
| url | https://doi.org/10.1371/journal.ppat.1012811 |
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