Advances, challenges and future applications of liver organoids in experimental regenerative medicine
The liver is a vital organ responsible for numerous metabolic processes in the human body, including the metabolism of drugs and nutrients. After liver damage, the organ can rapidly return to its original size if the causative factor is promptly eliminated. However, when the harmful stimulus persist...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1521851/full |
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| author | Da Gong Jiaye Mo Jiaye Mo Mei Zhai Fulin Zhou Guocai Wang Shaohua Ma Xiaoyong Dai Xiaoyong Dai Xuesong Deng |
| author_facet | Da Gong Jiaye Mo Jiaye Mo Mei Zhai Fulin Zhou Guocai Wang Shaohua Ma Xiaoyong Dai Xiaoyong Dai Xuesong Deng |
| author_sort | Da Gong |
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| description | The liver is a vital organ responsible for numerous metabolic processes in the human body, including the metabolism of drugs and nutrients. After liver damage, the organ can rapidly return to its original size if the causative factor is promptly eliminated. However, when the harmful stimulus persists, the liver’s regenerative capacity becomes compromised. Substantial theoretical feasibility has been demonstrated at the levels of gene expression, molecular interactions, and intercellular dynamics, complemented by numerous successful animal studies. However, a robust model and carrier that closely resemble human physiology are still lacking for translating these theories into practice. The potential for liver regeneration has been a central focus of ongoing research. Over the past decade, the advent of organoid technology has provided improved models and materials for advancing research efforts. Liver organoid technology represents a novel in vitro culture system. After several years of refinement, human liver organoids can now accurately replicate the liver’s morphological structure, nutrient and drug metabolism, gene expression, and secretory functions, providing a robust model for liver disease research. Regenerative medicine aims to replicate human organ or tissue functions to repair or replace damaged tissues, restore their structure or function, or stimulate the regeneration of tissues or organs within the body. Liver organoids possess the same structure and function as liver tissue, offering the potential to serve as a viable replacement for the liver, aligning with the goals of regenerative medicine. This review examines the role of liver organoids in regenerative medicine. |
| format | Article |
| id | doaj-art-5939560b1c734caca897dacc98538d61 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-5939560b1c734caca897dacc98538d612025-01-24T14:48:45ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.15218511521851Advances, challenges and future applications of liver organoids in experimental regenerative medicineDa Gong0Jiaye Mo1Jiaye Mo2Mei Zhai3Fulin Zhou4Guocai Wang5Shaohua Ma6Xiaoyong Dai7Xiaoyong Dai8Xuesong Deng9Department of Hepatobiliary Surgery, the First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People’s Hospital, Shenzhen, ChinaDepartment of Hepatobiliary Surgery, the First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People’s Hospital, Shenzhen, ChinaGuangxi University of Chinese Medicine, Nanning, ChinaDepartment of Hepatobiliary Surgery, the First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People’s Hospital, Shenzhen, ChinaDepartment of Clinical Medicine, Guizhou Medical University, Guiyang, ChinaDepartment of Physiology, School of Medicine and State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, ChinaInstitute of Biopharmaceutical and Health Engineering, Shenzhen Key Laboratory of Gene and Antibody Therapy, State Key Laboratory of Chemical Oncogenomics, Tsinghua University Shenzhen International Graduate School, Guangdong, ChinaDepartment of Physiology, School of Medicine and State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, ChinaInstitute of Biopharmaceutical and Health Engineering, Shenzhen Key Laboratory of Gene and Antibody Therapy, State Key Laboratory of Chemical Oncogenomics, Tsinghua University Shenzhen International Graduate School, Guangdong, ChinaDepartment of Hepatobiliary Surgery, the First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People’s Hospital, Shenzhen, ChinaThe liver is a vital organ responsible for numerous metabolic processes in the human body, including the metabolism of drugs and nutrients. After liver damage, the organ can rapidly return to its original size if the causative factor is promptly eliminated. However, when the harmful stimulus persists, the liver’s regenerative capacity becomes compromised. Substantial theoretical feasibility has been demonstrated at the levels of gene expression, molecular interactions, and intercellular dynamics, complemented by numerous successful animal studies. However, a robust model and carrier that closely resemble human physiology are still lacking for translating these theories into practice. The potential for liver regeneration has been a central focus of ongoing research. Over the past decade, the advent of organoid technology has provided improved models and materials for advancing research efforts. Liver organoid technology represents a novel in vitro culture system. After several years of refinement, human liver organoids can now accurately replicate the liver’s morphological structure, nutrient and drug metabolism, gene expression, and secretory functions, providing a robust model for liver disease research. Regenerative medicine aims to replicate human organ or tissue functions to repair or replace damaged tissues, restore their structure or function, or stimulate the regeneration of tissues or organs within the body. Liver organoids possess the same structure and function as liver tissue, offering the potential to serve as a viable replacement for the liver, aligning with the goals of regenerative medicine. This review examines the role of liver organoids in regenerative medicine.https://www.frontiersin.org/articles/10.3389/fmed.2024.1521851/fullliver organoidsregenerative medicineliver injuryliver research modelmicrofluidic and 3D printorganoids-on-a-chip |
| spellingShingle | Da Gong Jiaye Mo Jiaye Mo Mei Zhai Fulin Zhou Guocai Wang Shaohua Ma Xiaoyong Dai Xiaoyong Dai Xuesong Deng Advances, challenges and future applications of liver organoids in experimental regenerative medicine Frontiers in Medicine liver organoids regenerative medicine liver injury liver research model microfluidic and 3D print organoids-on-a-chip |
| title | Advances, challenges and future applications of liver organoids in experimental regenerative medicine |
| title_full | Advances, challenges and future applications of liver organoids in experimental regenerative medicine |
| title_fullStr | Advances, challenges and future applications of liver organoids in experimental regenerative medicine |
| title_full_unstemmed | Advances, challenges and future applications of liver organoids in experimental regenerative medicine |
| title_short | Advances, challenges and future applications of liver organoids in experimental regenerative medicine |
| title_sort | advances challenges and future applications of liver organoids in experimental regenerative medicine |
| topic | liver organoids regenerative medicine liver injury liver research model microfluidic and 3D print organoids-on-a-chip |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1521851/full |
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