Clinical Features, Pathophysiology, and Treatment of Levodopa-Induced Dyskinesias in Parkinson’s Disease
Dyskinetic disorders are characterized by excess of motor activity that may interfere with normal movement control. In patients with Parkinson’s disease, the chronic levodopa treatment induces dyskinetic movements known as levodopa-induced dyskinesias (LID). This paper analyzed the pathophysiology,...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2012/943159 |
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| _version_ | 1832564193735213056 |
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| author | J. Guridi R. González-Redondo J. A. Obeso |
| author_facet | J. Guridi R. González-Redondo J. A. Obeso |
| author_sort | J. Guridi |
| collection | DOAJ |
| description | Dyskinetic disorders are characterized by excess of motor activity that may interfere with normal movement control. In patients with Parkinson’s disease, the chronic levodopa treatment induces dyskinetic movements known as levodopa-induced dyskinesias (LID). This paper analyzed the pathophysiology, clinical manifestations, pharmacological treatments, and surgical procedures to treat hyperkinetic disorders. Surgery is currently the only treatment available for Parkinson’s disease that may improve both parkinsonian motor syndrome and LID. However, this paper shows the different mechanisms involved are not well understood. |
| format | Article |
| id | doaj-art-59384cbfb9a646a5b27a2db2f2a933de |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-59384cbfb9a646a5b27a2db2f2a933de2025-02-03T01:11:31ZengWileyParkinson's Disease2090-80832042-00802012-01-01201210.1155/2012/943159943159Clinical Features, Pathophysiology, and Treatment of Levodopa-Induced Dyskinesias in Parkinson’s DiseaseJ. Guridi0R. González-Redondo1J. A. Obeso2Department of Neurosurgery and Neurology, Clinica Universidad de Navarra, 31008 Pamplona, SpainDepartment of Neurosurgery and Neurology, Clinica Universidad de Navarra, 31008 Pamplona, SpainDepartment of Neurosurgery and Neurology, Clinica Universidad de Navarra, 31008 Pamplona, SpainDyskinetic disorders are characterized by excess of motor activity that may interfere with normal movement control. In patients with Parkinson’s disease, the chronic levodopa treatment induces dyskinetic movements known as levodopa-induced dyskinesias (LID). This paper analyzed the pathophysiology, clinical manifestations, pharmacological treatments, and surgical procedures to treat hyperkinetic disorders. Surgery is currently the only treatment available for Parkinson’s disease that may improve both parkinsonian motor syndrome and LID. However, this paper shows the different mechanisms involved are not well understood.http://dx.doi.org/10.1155/2012/943159 |
| spellingShingle | J. Guridi R. González-Redondo J. A. Obeso Clinical Features, Pathophysiology, and Treatment of Levodopa-Induced Dyskinesias in Parkinson’s Disease Parkinson's Disease |
| title | Clinical Features, Pathophysiology, and Treatment of Levodopa-Induced Dyskinesias in Parkinson’s Disease |
| title_full | Clinical Features, Pathophysiology, and Treatment of Levodopa-Induced Dyskinesias in Parkinson’s Disease |
| title_fullStr | Clinical Features, Pathophysiology, and Treatment of Levodopa-Induced Dyskinesias in Parkinson’s Disease |
| title_full_unstemmed | Clinical Features, Pathophysiology, and Treatment of Levodopa-Induced Dyskinesias in Parkinson’s Disease |
| title_short | Clinical Features, Pathophysiology, and Treatment of Levodopa-Induced Dyskinesias in Parkinson’s Disease |
| title_sort | clinical features pathophysiology and treatment of levodopa induced dyskinesias in parkinson s disease |
| url | http://dx.doi.org/10.1155/2012/943159 |
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