Correlation between extent and clinical severity, and histopathological characteristics of geographic tongue
BACKGROUND: Geographic tongue is an oral lesion with an unknown etiology.Recently, the Geographic Tongue Area and Sev erity Index (GTASI) has been proposed to assess the area and severity of geographic tongue, aiming to measure the clinical severity of this condition. However, this index does not ac...
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| Format: | Article |
| Language: | English |
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Via Medica
2025-01-01
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| Series: | Folia Morphologica |
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| Online Access: | https://journals.viamedica.pl/folia_morphologica/article/view/101042 |
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| author | Thaylla Núñez Amin Dick Lílian Rocha Santos Karin Soares Cunha Geraldo Oliveira Silva-Junior Arkadiusz Dziedzic Mariana Marinho Aredes Arley Silva Junior Heron Fernando Gonzaga Eliane Pedra Dias Bruna Lavinas Sayed Picciani |
| author_facet | Thaylla Núñez Amin Dick Lílian Rocha Santos Karin Soares Cunha Geraldo Oliveira Silva-Junior Arkadiusz Dziedzic Mariana Marinho Aredes Arley Silva Junior Heron Fernando Gonzaga Eliane Pedra Dias Bruna Lavinas Sayed Picciani |
| author_sort | Thaylla Núñez Amin Dick |
| collection | DOAJ |
| description | BACKGROUND: Geographic tongue is an oral lesion with an unknown etiology.Recently, the Geographic Tongue Area and Sev erity Index (GTASI) has been proposed to assess the area and severity of geographic tongue, aiming to measure the clinical severity of this condition. However, this index does not account for the histopathology, which may vary based on the clinical stage of the lesion and the biopsy area. Our present study aimed to evaluate the correlation between GTASI score and its histopathological features.
Materials and methods: This cross-sectional observational study included 40 participants diagnosed with GT confirmed both clinically and histopathologically.
RESULTS: Considering GT severity, the majority, 60%, of cases were classified as mild, with female predominance in both the mild and severe categories. The average age of participants was 56 for mild and severe cases and 47 for moderate ones. The prevalent histopathological features of geographic tongue included parakeratosis, acanthosis, spongiosis, basal layer hyperplasia, mono- and polymorphonuclear exocytosis, suprapapillary hypotrophy, claviform epithelial ridges, fusion of epithelial ridges, conjunctival papillary oedema, and chronic subepithelial infiltration, with no significant differences taking into consideration the clinical severity level. Papillary vascular ectasia, Munro microabscesses, Kogoj pustules, and dense connective tissue were more prevalent in patients with more severe cases of GT. Mild inflammatory infiltrate intensity was predominant in patients with mild GT, while moderate infiltrate intensity was found predominantly in moderate cases of GT.
CONCLUSIONS: The clinical severity level of GT closely corresponds with its histopathological characteristics. |
| format | Article |
| id | doaj-art-591fcccd825e4b83aaff46606d00a53a |
| institution | Kabale University |
| issn | 0015-5659 1644-3284 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Via Medica |
| record_format | Article |
| series | Folia Morphologica |
| spelling | doaj-art-591fcccd825e4b83aaff46606d00a53a2025-08-20T13:27:56ZengVia MedicaFolia Morphologica0015-56591644-32842025-01-0184210.5603/fm.101042Correlation between extent and clinical severity, and histopathological characteristics of geographic tongueThaylla Núñez Amin Dick0https://orcid.org/0000-0001-6401-1209Lílian Rocha Santos1Karin Soares Cunha2Geraldo Oliveira Silva-Junior3https://orcid.org/0000-0003-0987-2684Arkadiusz Dziedzic4https://orcid.org/0000-0003-0022-8382Mariana Marinho Aredes5Arley Silva Junior6https://orcid.org/0000-0003-1839-2789Heron Fernando Gonzaga7https://orcid.org/0000-0001-9979-6472Eliane Pedra Dias8https://orcid.org/0000-0002-0917-6091Bruna Lavinas Sayed Picciani9https://orcid.org/0000-0001-7592-1785Postgraduate Program in Pathology, Department of Pathology, School of Medicine, Fluminense Federal University, Niterói, BrazilPostgraduate Program in Pathology, Department of Pathology, School of Medicine, Fluminense Federal University, Niterói, BrazilPostgraduate Program in Pathology, Department of Pathology, School of Medicine, Fluminense Federal University, Niterói, BrazilDepartment of Diagnosis and Therapeutics, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, BrazilDepartment of Conservative Dentistry with Endodontics, Medical University of Silesia, Katowice, PolandPostgraduate Program in Dentistry, Health Institute of Nova Friburgo, Fluminense Federal University, Nova Friburgo, BrazilPostgraduate Program in Pathology, Department of Pathology, School of Medicine, Fluminense Federal University, Niterói, BrazilDepartment of Dermatology, School of Medicine, São Paulo Federal University, São Paulo, BrazilPostgraduate Program in Pathology, Department of Pathology, School of Medicine, Fluminense Federal University, Niterói, BrazilPostgraduate Program in Dentistry, Health Institute of Nova Friburgo, Fluminense Federal University, Nova Friburgo, BrazilBACKGROUND: Geographic tongue is an oral lesion with an unknown etiology.Recently, the Geographic Tongue Area and Sev erity Index (GTASI) has been proposed to assess the area and severity of geographic tongue, aiming to measure the clinical severity of this condition. However, this index does not account for the histopathology, which may vary based on the clinical stage of the lesion and the biopsy area. Our present study aimed to evaluate the correlation between GTASI score and its histopathological features. Materials and methods: This cross-sectional observational study included 40 participants diagnosed with GT confirmed both clinically and histopathologically. RESULTS: Considering GT severity, the majority, 60%, of cases were classified as mild, with female predominance in both the mild and severe categories. The average age of participants was 56 for mild and severe cases and 47 for moderate ones. The prevalent histopathological features of geographic tongue included parakeratosis, acanthosis, spongiosis, basal layer hyperplasia, mono- and polymorphonuclear exocytosis, suprapapillary hypotrophy, claviform epithelial ridges, fusion of epithelial ridges, conjunctival papillary oedema, and chronic subepithelial infiltration, with no significant differences taking into consideration the clinical severity level. Papillary vascular ectasia, Munro microabscesses, Kogoj pustules, and dense connective tissue were more prevalent in patients with more severe cases of GT. Mild inflammatory infiltrate intensity was predominant in patients with mild GT, while moderate infiltrate intensity was found predominantly in moderate cases of GT. CONCLUSIONS: The clinical severity level of GT closely corresponds with its histopathological characteristics.https://journals.viamedica.pl/folia_morphologica/article/view/101042benign migratory glossitishistopathologygeographic tongueSeverity of Illness index |
| spellingShingle | Thaylla Núñez Amin Dick Lílian Rocha Santos Karin Soares Cunha Geraldo Oliveira Silva-Junior Arkadiusz Dziedzic Mariana Marinho Aredes Arley Silva Junior Heron Fernando Gonzaga Eliane Pedra Dias Bruna Lavinas Sayed Picciani Correlation between extent and clinical severity, and histopathological characteristics of geographic tongue Folia Morphologica benign migratory glossitis histopathology geographic tongue Severity of Illness index |
| title | Correlation between extent and clinical severity, and histopathological characteristics of geographic tongue |
| title_full | Correlation between extent and clinical severity, and histopathological characteristics of geographic tongue |
| title_fullStr | Correlation between extent and clinical severity, and histopathological characteristics of geographic tongue |
| title_full_unstemmed | Correlation between extent and clinical severity, and histopathological characteristics of geographic tongue |
| title_short | Correlation between extent and clinical severity, and histopathological characteristics of geographic tongue |
| title_sort | correlation between extent and clinical severity and histopathological characteristics of geographic tongue |
| topic | benign migratory glossitis histopathology geographic tongue Severity of Illness index |
| url | https://journals.viamedica.pl/folia_morphologica/article/view/101042 |
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