Autoantibodies in myasthenia gravis: cluster analysis and clinical correlations
ObjectiveThis study aimed to explore autoantibody clusters and their correlations with clinical features in 644 myasthenia gravis (MG) patients.MethodsMedical records of 664 MG patients were reviewed. Five autoantibodies (AChR, MuSK, titin, RyR, and LRP4) were selected for cluster analysis. The vari...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1537783/full |
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| author | Xupeng Sun Meijie Qu Xi Rong Mingxing Lv Yunbin Zhao Yunjun Yan Lin Liu Na Sun Hua Yue Min Liu |
| author_facet | Xupeng Sun Meijie Qu Xi Rong Mingxing Lv Yunbin Zhao Yunjun Yan Lin Liu Na Sun Hua Yue Min Liu |
| author_sort | Xupeng Sun |
| collection | DOAJ |
| description | ObjectiveThis study aimed to explore autoantibody clusters and their correlations with clinical features in 644 myasthenia gravis (MG) patients.MethodsMedical records of 664 MG patients were reviewed. Five autoantibodies (AChR, MuSK, titin, RyR, and LRP4) were selected for cluster analysis. The various clinical manifestations were compared between clusters. Separate association analyses between individual autoantibodies and clinical manifestations as well as among different MGFA subtypes were also performed without prior clustering.ResultsTwo separate autoantibody clusters were identified, with significantly different clinical manifestations. Cluster 1 (485 patients) was characterized by higher proportions of RyR-, titin-, and AChR-, while cluster 2 (179 patients) had higher proportions of RyR+, titin+, and AChR+. Cluster 2 patients were older and had elevated QMG scores and odds of complications, particularly hypertension, diabetes, cardiovascular and cerebrovascular diseases, and eye conditions. Individual antibody analysis revealed that male cases were more likely to be AChR+ and titin+, and older age was associated with AChR+, RyR+, and titin+. Among MGFA subtypes, significant differences were detected in AChR, MuSK, titin, complications, thymoma, and hypertension. As MG severity increased from types I to V, AChR+, RyR+, and titin+ proportions peaked at stage IIa. MuSK+ patients were relatively rare and mostly present in the subtype b group. Type b patients had higher MuSK+ prevalence and increased cardiovascular and cerebrovascular disease incidence rates than type a cases.ConclusionOverall, cluster 2 features were less favorable to patients. This study provides valuable insights into the clinical and autoantibody profiles of Chinese MG patients. |
| format | Article |
| id | doaj-art-5916ee63c4f44c01b7cd63ffbd716427 |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-5916ee63c4f44c01b7cd63ffbd7164272025-02-04T16:13:06ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-02-011610.3389/fneur.2025.15377831537783Autoantibodies in myasthenia gravis: cluster analysis and clinical correlationsXupeng Sun0Meijie Qu1Xi Rong2Mingxing Lv3Yunbin Zhao4Yunjun Yan5Lin Liu6Na Sun7Hua Yue8Min Liu9Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Neurology, Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Neurology, Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Neurology, Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Neurology, Affiliated Hospital of Qingdao University, Qingdao, ChinaJinan Dian Medical Laboratory Co., Ltd., Jinan, ChinaKey Laboratory of Digital Technology in Medical Diagnostics of Zhejiang Province, Dian Diagnostics Group Co., Ltd., Hangzhou, ChinaJinan Dian Medical Laboratory Co., Ltd., Jinan, ChinaDepartment of Neurology, Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Neurology, Affiliated Hospital of Qingdao University, Qingdao, ChinaObjectiveThis study aimed to explore autoantibody clusters and their correlations with clinical features in 644 myasthenia gravis (MG) patients.MethodsMedical records of 664 MG patients were reviewed. Five autoantibodies (AChR, MuSK, titin, RyR, and LRP4) were selected for cluster analysis. The various clinical manifestations were compared between clusters. Separate association analyses between individual autoantibodies and clinical manifestations as well as among different MGFA subtypes were also performed without prior clustering.ResultsTwo separate autoantibody clusters were identified, with significantly different clinical manifestations. Cluster 1 (485 patients) was characterized by higher proportions of RyR-, titin-, and AChR-, while cluster 2 (179 patients) had higher proportions of RyR+, titin+, and AChR+. Cluster 2 patients were older and had elevated QMG scores and odds of complications, particularly hypertension, diabetes, cardiovascular and cerebrovascular diseases, and eye conditions. Individual antibody analysis revealed that male cases were more likely to be AChR+ and titin+, and older age was associated with AChR+, RyR+, and titin+. Among MGFA subtypes, significant differences were detected in AChR, MuSK, titin, complications, thymoma, and hypertension. As MG severity increased from types I to V, AChR+, RyR+, and titin+ proportions peaked at stage IIa. MuSK+ patients were relatively rare and mostly present in the subtype b group. Type b patients had higher MuSK+ prevalence and increased cardiovascular and cerebrovascular disease incidence rates than type a cases.ConclusionOverall, cluster 2 features were less favorable to patients. This study provides valuable insights into the clinical and autoantibody profiles of Chinese MG patients.https://www.frontiersin.org/articles/10.3389/fneur.2025.1537783/fullmyasthenia gravisantibodiesclinical manifestationscluster analysisclinical research |
| spellingShingle | Xupeng Sun Meijie Qu Xi Rong Mingxing Lv Yunbin Zhao Yunjun Yan Lin Liu Na Sun Hua Yue Min Liu Autoantibodies in myasthenia gravis: cluster analysis and clinical correlations Frontiers in Neurology myasthenia gravis antibodies clinical manifestations cluster analysis clinical research |
| title | Autoantibodies in myasthenia gravis: cluster analysis and clinical correlations |
| title_full | Autoantibodies in myasthenia gravis: cluster analysis and clinical correlations |
| title_fullStr | Autoantibodies in myasthenia gravis: cluster analysis and clinical correlations |
| title_full_unstemmed | Autoantibodies in myasthenia gravis: cluster analysis and clinical correlations |
| title_short | Autoantibodies in myasthenia gravis: cluster analysis and clinical correlations |
| title_sort | autoantibodies in myasthenia gravis cluster analysis and clinical correlations |
| topic | myasthenia gravis antibodies clinical manifestations cluster analysis clinical research |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1537783/full |
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