Case Study of a Parotid Gland Adenocarcinoma Dedifferentiated from Epithelial-Myoepithelial Carcinoma
Dedifferentiation is defined as high-grade malignant tumor development out of a low-grade malignant tumor. We present an adenocarcinoma tumor of the parotid gland that was dedifferentiated from a low-grade epithelial-myoepithelial carcinoma and was followed up for 3 years. Our patient, a 46-year-ol...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Otolaryngology |
| Online Access: | http://dx.doi.org/10.1155/2014/629054 |
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| author | Salih Aydın Umit Taskin Kadir Ozdamar Kadir Yücebas Mehmet Sar Mehmet Faruk Oktay Ümit Seza Tetikkurt |
| author_facet | Salih Aydın Umit Taskin Kadir Ozdamar Kadir Yücebas Mehmet Sar Mehmet Faruk Oktay Ümit Seza Tetikkurt |
| author_sort | Salih Aydın |
| collection | DOAJ |
| description | Dedifferentiation is defined as high-grade malignant tumor development out of a low-grade malignant tumor. We present an adenocarcinoma tumor of the parotid gland that was dedifferentiated from a low-grade epithelial-myoepithelial carcinoma and was followed up for 3 years. Our patient, a 46-year-old female, presented with a left parotid mass of 20-year duration. Histopathologic results showed that there was only one area of typical epithelial-myoepithelial carcinoma, with foci of poorly differentiated adenocarcinoma (not otherwise specified; NOS) and clear cytoplasm in the parotid gland. Immunohistochemical staining results showed SMA (+), P63 (+), CK8 (+), and S100 (+) on epithelial cells. A review of the literature revealed 22 previously reported cases of dedifferentiated epithelial-myoepithelial carcinoma. In these cases, the malignant tumors that dedifferentiated from epithelial-myoepithelial carcinoma were adenoid cystic carcinoma, actinic cell carcinoma, polymorphous low-grade adenocarcinoma, mucoepidermoid carcinoma, and intraductal carcinoma. In our case, the malignant tumor that dedifferentiated from the epithelial-myoepithelial carcinoma was a poorly differentiated adenocarcinoma. Histopathological results showed that metastases were not seen in the neck-dissection material. As a result, our case will make a contribution to the literature in terms of prognosis, because there are very few reported cases of dedifferentiated adenocarcinoma development arising from epithelial-myoepithelial carcinoma. |
| format | Article |
| id | doaj-art-590f86202a2b4913aef65262f7dbbde4 |
| institution | Kabale University |
| issn | 2090-6765 2090-6773 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Otolaryngology |
| spelling | doaj-art-590f86202a2b4913aef65262f7dbbde42025-02-03T01:06:44ZengWileyCase Reports in Otolaryngology2090-67652090-67732014-01-01201410.1155/2014/629054629054Case Study of a Parotid Gland Adenocarcinoma Dedifferentiated from Epithelial-Myoepithelial CarcinomaSalih Aydın0Umit Taskin1Kadir Ozdamar2Kadir Yücebas3Mehmet Sar4Mehmet Faruk Oktay5Ümit Seza Tetikkurt6Department of Otolaryngology, Bağcılar Education and Research Hospital, Istanbul, TurkeyDepartment of Otolaryngology, Bağcılar Education and Research Hospital, Istanbul, TurkeyDepartment of Otolaryngology, Bağcılar Education and Research Hospital, Istanbul, TurkeyDepartment of Otolaryngology, Bağcılar Education and Research Hospital, Istanbul, TurkeyDepartment of Pathology, Bağcılar Education and Research Hospital, Istanbul, TurkeyDepartment of Otolaryngology, Bağcılar Education and Research Hospital, Istanbul, TurkeyDepartment of Pathology, Bağcılar Education and Research Hospital, Istanbul, TurkeyDedifferentiation is defined as high-grade malignant tumor development out of a low-grade malignant tumor. We present an adenocarcinoma tumor of the parotid gland that was dedifferentiated from a low-grade epithelial-myoepithelial carcinoma and was followed up for 3 years. Our patient, a 46-year-old female, presented with a left parotid mass of 20-year duration. Histopathologic results showed that there was only one area of typical epithelial-myoepithelial carcinoma, with foci of poorly differentiated adenocarcinoma (not otherwise specified; NOS) and clear cytoplasm in the parotid gland. Immunohistochemical staining results showed SMA (+), P63 (+), CK8 (+), and S100 (+) on epithelial cells. A review of the literature revealed 22 previously reported cases of dedifferentiated epithelial-myoepithelial carcinoma. In these cases, the malignant tumors that dedifferentiated from epithelial-myoepithelial carcinoma were adenoid cystic carcinoma, actinic cell carcinoma, polymorphous low-grade adenocarcinoma, mucoepidermoid carcinoma, and intraductal carcinoma. In our case, the malignant tumor that dedifferentiated from the epithelial-myoepithelial carcinoma was a poorly differentiated adenocarcinoma. Histopathological results showed that metastases were not seen in the neck-dissection material. As a result, our case will make a contribution to the literature in terms of prognosis, because there are very few reported cases of dedifferentiated adenocarcinoma development arising from epithelial-myoepithelial carcinoma.http://dx.doi.org/10.1155/2014/629054 |
| spellingShingle | Salih Aydın Umit Taskin Kadir Ozdamar Kadir Yücebas Mehmet Sar Mehmet Faruk Oktay Ümit Seza Tetikkurt Case Study of a Parotid Gland Adenocarcinoma Dedifferentiated from Epithelial-Myoepithelial Carcinoma Case Reports in Otolaryngology |
| title | Case Study of a Parotid Gland Adenocarcinoma Dedifferentiated from Epithelial-Myoepithelial Carcinoma |
| title_full | Case Study of a Parotid Gland Adenocarcinoma Dedifferentiated from Epithelial-Myoepithelial Carcinoma |
| title_fullStr | Case Study of a Parotid Gland Adenocarcinoma Dedifferentiated from Epithelial-Myoepithelial Carcinoma |
| title_full_unstemmed | Case Study of a Parotid Gland Adenocarcinoma Dedifferentiated from Epithelial-Myoepithelial Carcinoma |
| title_short | Case Study of a Parotid Gland Adenocarcinoma Dedifferentiated from Epithelial-Myoepithelial Carcinoma |
| title_sort | case study of a parotid gland adenocarcinoma dedifferentiated from epithelial myoepithelial carcinoma |
| url | http://dx.doi.org/10.1155/2014/629054 |
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