GIANT CELL TUMOR OF THE DISTAL RADIUS: FACTORS ASSOCIATED WITH LOCAL RECURRENCE
Abstract Objectives: To assess patient and tumor characteristics and treatment outcomes, focusing on local recurrence rates based on treatment type. Methods: This is a retrospective review of cases of GCTB of the distal radius, identified from the databases of 74 patients in Brazilian institutions...
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Sociedade Brasileira de Ortopedia e Traumatologia
2025-02-01
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| Series: | Acta Ortopédica Brasileira |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522025000100802&lng=en&tlng=en |
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| author | William Bernardo Specht Rabuske Michelle Ghert Bruno Pereira Antunes Carlos Roberto Galia Julie Francine Cerutti Santos Pestilho Gabriella Sityá Moojen da Silveira Eduardo Areas Toller Olavo Pires de Camargo Edgard Eduard Engel Suely Akiko Nakagawa Alex Guedes Ricardo Gehrke Becker |
| author_facet | William Bernardo Specht Rabuske Michelle Ghert Bruno Pereira Antunes Carlos Roberto Galia Julie Francine Cerutti Santos Pestilho Gabriella Sityá Moojen da Silveira Eduardo Areas Toller Olavo Pires de Camargo Edgard Eduard Engel Suely Akiko Nakagawa Alex Guedes Ricardo Gehrke Becker |
| author_sort | William Bernardo Specht Rabuske |
| collection | DOAJ |
| description | Abstract Objectives: To assess patient and tumor characteristics and treatment outcomes, focusing on local recurrence rates based on treatment type. Methods: This is a retrospective review of cases of GCTB of the distal radius, identified from the databases of 74 patients in Brazilian institutions specializing in musculoskeletal tumor treatment. Data were collected from electronic and paper medical records by 18 centers between 1989 and 2021. Variables included demographic data, clinical presentation, treatment-related factors, and primary outcome (local recurrence rate). Results: Among the 74 patients in the study, the mean age at diagnosis was 32.6 years, with a slight female predominance. Pathological fractures on presentation were observed in 15.7% of patients, and pulmonary metastasis in 1.4%. Treatment approaches were divided equally between intralesional curettage and en bloc resection. The overall local recurrence rate was 25.7% and was higher in patients treated with intralesional curettage (35.1%) compared to resection (16.2%). Conclusions: The study confirms high recurrence risk with intralesional curettage, emphasizing the need for standardized protocols and improved surgical techniques to reduce recurrence rates and enhance outcomes for distal radius GCTB patients. Level of Evidence III; Retrospective Cohort Study. |
| format | Article |
| id | doaj-art-58ff59efb92345c192c71ff11eb2d4aa |
| institution | Kabale University |
| issn | 1413-7852 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Sociedade Brasileira de Ortopedia e Traumatologia |
| record_format | Article |
| series | Acta Ortopédica Brasileira |
| spelling | doaj-art-58ff59efb92345c192c71ff11eb2d4aa2025-02-04T07:41:46ZengSociedade Brasileira de Ortopedia e TraumatologiaActa Ortopédica Brasileira1413-78522025-02-0133110.1590/1413-785220253301e289573GIANT CELL TUMOR OF THE DISTAL RADIUS: FACTORS ASSOCIATED WITH LOCAL RECURRENCEWilliam Bernardo Specht Rabuskehttps://orcid.org/0000-0001-8051-6223Michelle Gherthttps://orcid.org/0000-0002-4778-4522Bruno Pereira Antuneshttps://orcid.org/0000-0003-1102-3083Carlos Roberto Galiahttps://orcid.org/0000-0003-1731-4543Julie Francine Cerutti Santos Pestilhohttps://orcid.org/0000-0003-3630-8595Gabriella Sityá Moojen da Silveirahttps://orcid.org/0000-0002-4962-6843Eduardo Areas Tollerhttps://orcid.org/0000-0002-2605-7975Olavo Pires de Camargohttps://orcid.org/0000-0002-1128-7292Edgard Eduard Engelhttps://orcid.org/0000-0002-4047-2796Suely Akiko Nakagawahttps://orcid.org/0000-0002-9195-2087Alex Guedeshttps://orcid.org/0000-0001-7013-7107Ricardo Gehrke Beckerhttps://orcid.org/0000-0003-2629-9752Abstract Objectives: To assess patient and tumor characteristics and treatment outcomes, focusing on local recurrence rates based on treatment type. Methods: This is a retrospective review of cases of GCTB of the distal radius, identified from the databases of 74 patients in Brazilian institutions specializing in musculoskeletal tumor treatment. Data were collected from electronic and paper medical records by 18 centers between 1989 and 2021. Variables included demographic data, clinical presentation, treatment-related factors, and primary outcome (local recurrence rate). Results: Among the 74 patients in the study, the mean age at diagnosis was 32.6 years, with a slight female predominance. Pathological fractures on presentation were observed in 15.7% of patients, and pulmonary metastasis in 1.4%. Treatment approaches were divided equally between intralesional curettage and en bloc resection. The overall local recurrence rate was 25.7% and was higher in patients treated with intralesional curettage (35.1%) compared to resection (16.2%). Conclusions: The study confirms high recurrence risk with intralesional curettage, emphasizing the need for standardized protocols and improved surgical techniques to reduce recurrence rates and enhance outcomes for distal radius GCTB patients. Level of Evidence III; Retrospective Cohort Study.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522025000100802&lng=en&tlng=enBone NeoplasmsGiant Cell TumorsGiant Cell Tumor of BoneCurettageDenosumabRecurrence |
| spellingShingle | William Bernardo Specht Rabuske Michelle Ghert Bruno Pereira Antunes Carlos Roberto Galia Julie Francine Cerutti Santos Pestilho Gabriella Sityá Moojen da Silveira Eduardo Areas Toller Olavo Pires de Camargo Edgard Eduard Engel Suely Akiko Nakagawa Alex Guedes Ricardo Gehrke Becker GIANT CELL TUMOR OF THE DISTAL RADIUS: FACTORS ASSOCIATED WITH LOCAL RECURRENCE Acta Ortopédica Brasileira Bone Neoplasms Giant Cell Tumors Giant Cell Tumor of Bone Curettage Denosumab Recurrence |
| title | GIANT CELL TUMOR OF THE DISTAL RADIUS: FACTORS ASSOCIATED WITH LOCAL RECURRENCE |
| title_full | GIANT CELL TUMOR OF THE DISTAL RADIUS: FACTORS ASSOCIATED WITH LOCAL RECURRENCE |
| title_fullStr | GIANT CELL TUMOR OF THE DISTAL RADIUS: FACTORS ASSOCIATED WITH LOCAL RECURRENCE |
| title_full_unstemmed | GIANT CELL TUMOR OF THE DISTAL RADIUS: FACTORS ASSOCIATED WITH LOCAL RECURRENCE |
| title_short | GIANT CELL TUMOR OF THE DISTAL RADIUS: FACTORS ASSOCIATED WITH LOCAL RECURRENCE |
| title_sort | giant cell tumor of the distal radius factors associated with local recurrence |
| topic | Bone Neoplasms Giant Cell Tumors Giant Cell Tumor of Bone Curettage Denosumab Recurrence |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522025000100802&lng=en&tlng=en |
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