Similar Strains of Coagulase-Negative Staphylococci Found in the Gastrointestinal Tract and Bloodstream of Bacteremic Neonates
Objectives. Premature neonates are susceptible to opportunistic and nosocomial infections. Efforts have been made to determine whether the neonatal gut microbiome possesses potential for causing bloodstream infections in newborns via microbial translocation from the gastrointestinal tract. We aimed...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2020/3509676 |
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| author | Jennifer O. Adeghate Emese Juhász Miklós Á. Iván Júlia Pongrácz Katalin Kristóf |
| author_facet | Jennifer O. Adeghate Emese Juhász Miklós Á. Iván Júlia Pongrácz Katalin Kristóf |
| author_sort | Jennifer O. Adeghate |
| collection | DOAJ |
| description | Objectives. Premature neonates are susceptible to opportunistic and nosocomial infections. Efforts have been made to determine whether the neonatal gut microbiome possesses potential for causing bloodstream infections in newborns via microbial translocation from the gastrointestinal tract. We aimed to examine similarities in coagulase-negative staphylococci (CoNS) strains found in the gastrointestinal tract and bloodstream in bacteremic neonates. Methods. CoNS strains isolated from blood cultures and perianal and pharyngeal swab samples of neonates from two neonatal intensive care units were investigated using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and pulsed-field gel electrophoresis. Molecular mass and genetic similarities of CoNS strains were compared. Results. Marked similarity was found in the molecular mass and genetic profile of examined CoNS isolates from blood cultures and perianal/pharyngeal samples. The percentage of neonates developing bacteremia following perianal and pharyngeal colonization by CoNS was significantly higher when compared to those colonized by Enterobacteriales species (p<0.0002). Conclusions. CoNS colonizing the gut may be a source of bacteremia in neonates. Enterobacteriales species do not contribute as significantly to bacteremia when compared to CoNS, and may be protective against gut mucosa-originated systemic infection. |
| format | Article |
| id | doaj-art-58ecfc61ff68489caae8bfb93d3d4ddd |
| institution | Kabale University |
| issn | 1712-9532 1918-1493 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-58ecfc61ff68489caae8bfb93d3d4ddd2025-02-03T01:03:40ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95321918-14932020-01-01202010.1155/2020/35096763509676Similar Strains of Coagulase-Negative Staphylococci Found in the Gastrointestinal Tract and Bloodstream of Bacteremic NeonatesJennifer O. Adeghate0Emese Juhász1Miklós Á. Iván2Júlia Pongrácz3Katalin Kristóf4Institute of Laboratory Medicine, Semmelweis University, Budapest 1082, HungaryInstitute of Laboratory Medicine, Semmelweis University, Budapest 1082, HungaryInstitute of Laboratory Medicine, Semmelweis University, Budapest 1082, HungaryInstitute of Laboratory Medicine, Semmelweis University, Budapest 1082, HungaryInstitute of Laboratory Medicine, Semmelweis University, Budapest 1082, HungaryObjectives. Premature neonates are susceptible to opportunistic and nosocomial infections. Efforts have been made to determine whether the neonatal gut microbiome possesses potential for causing bloodstream infections in newborns via microbial translocation from the gastrointestinal tract. We aimed to examine similarities in coagulase-negative staphylococci (CoNS) strains found in the gastrointestinal tract and bloodstream in bacteremic neonates. Methods. CoNS strains isolated from blood cultures and perianal and pharyngeal swab samples of neonates from two neonatal intensive care units were investigated using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and pulsed-field gel electrophoresis. Molecular mass and genetic similarities of CoNS strains were compared. Results. Marked similarity was found in the molecular mass and genetic profile of examined CoNS isolates from blood cultures and perianal/pharyngeal samples. The percentage of neonates developing bacteremia following perianal and pharyngeal colonization by CoNS was significantly higher when compared to those colonized by Enterobacteriales species (p<0.0002). Conclusions. CoNS colonizing the gut may be a source of bacteremia in neonates. Enterobacteriales species do not contribute as significantly to bacteremia when compared to CoNS, and may be protective against gut mucosa-originated systemic infection.http://dx.doi.org/10.1155/2020/3509676 |
| spellingShingle | Jennifer O. Adeghate Emese Juhász Miklós Á. Iván Júlia Pongrácz Katalin Kristóf Similar Strains of Coagulase-Negative Staphylococci Found in the Gastrointestinal Tract and Bloodstream of Bacteremic Neonates Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Similar Strains of Coagulase-Negative Staphylococci Found in the Gastrointestinal Tract and Bloodstream of Bacteremic Neonates |
| title_full | Similar Strains of Coagulase-Negative Staphylococci Found in the Gastrointestinal Tract and Bloodstream of Bacteremic Neonates |
| title_fullStr | Similar Strains of Coagulase-Negative Staphylococci Found in the Gastrointestinal Tract and Bloodstream of Bacteremic Neonates |
| title_full_unstemmed | Similar Strains of Coagulase-Negative Staphylococci Found in the Gastrointestinal Tract and Bloodstream of Bacteremic Neonates |
| title_short | Similar Strains of Coagulase-Negative Staphylococci Found in the Gastrointestinal Tract and Bloodstream of Bacteremic Neonates |
| title_sort | similar strains of coagulase negative staphylococci found in the gastrointestinal tract and bloodstream of bacteremic neonates |
| url | http://dx.doi.org/10.1155/2020/3509676 |
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