Glutamate enhances shrimp antibacterial ability by boosting its cellular immunity
Glutamate has been widely used in the feed industry to promote animal growth and enhance meat quality. However, its application in crustacean aquaculture remains relatively underexplored. In this study, we demonstrate a correlation between plasma glutamate increased the total hemocyte counts in shri...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Comparative Immunology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950311625000102 |
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| author | Lei Ma Wenyong Jiang Zhiyao Lu Yanmei Tong Qingyun Liu Zhonghua He Xiuli Chen Yongzhen Zhao Fan Wang |
| author_facet | Lei Ma Wenyong Jiang Zhiyao Lu Yanmei Tong Qingyun Liu Zhonghua He Xiuli Chen Yongzhen Zhao Fan Wang |
| author_sort | Lei Ma |
| collection | DOAJ |
| description | Glutamate has been widely used in the feed industry to promote animal growth and enhance meat quality. However, its application in crustacean aquaculture remains relatively underexplored. In this study, we demonstrate a correlation between plasma glutamate increased the total hemocyte counts in shrimp within two hours, an effect that was reversed by co-injection with a Grik2 inhibitor. Subsequent feeding trials showed that incorporating 0.25 % glutamate into shrimp diets significantly raised the glutamate concentration in muscle tissue, resulting in a 7 % increase in glutamate content. Moreover, feeding experiments combined with differential transcriptome analysis revealed that shrimp fed a diet supplemented with 0.25 % glutamate exhibited enhanced resistance to Vibrio infections, likely through the upregulation of immune-related genes. These findings suggest that glutamate not only improves the anti-Vibrio defenses of shrimp but also enhances their flavor profile. Therefore, glutamate could serve as a beneficial feed supplement to promote disease resistance in shrimp aquaculture. |
| format | Article |
| id | doaj-art-58e20dd2ba614f56944da58958370e2a |
| institution | Kabale University |
| issn | 2950-3116 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Comparative Immunology Reports |
| spelling | doaj-art-58e20dd2ba614f56944da58958370e2a2025-02-05T04:32:57ZengElsevierComparative Immunology Reports2950-31162025-06-018200204Glutamate enhances shrimp antibacterial ability by boosting its cellular immunityLei Ma0Wenyong Jiang1Zhiyao Lu2Yanmei Tong3Qingyun Liu4Zhonghua He5Xiuli Chen6Yongzhen Zhao7Fan Wang8Department of Biology, College of Science, Shantou University, Shantou, 515063, PR ChinaDepartment of Biology, College of Science, Shantou University, Shantou, 515063, PR ChinaDepartment of Biology, College of Science, Shantou University, Shantou, 515063, PR ChinaGuangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture, Guangxi Academy of Fishery Sciences, Nanning, 530021, PR ChinaGuangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture, Guangxi Academy of Fishery Sciences, Nanning, 530021, PR ChinaCollege of Fisheries, Huazhong agricultural University, Wuhan, 430070, PR ChinaGuangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture, Guangxi Academy of Fishery Sciences, Nanning, 530021, PR ChinaCorrespondence author at Guangxi Key Laboratory of Aquatic, Genetic Breeding and Healthy Aquaculture, Guangxi Academy of Fishery Sciences, Nanning, Guangdong, PR China 530021.; Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture, Guangxi Academy of Fishery Sciences, Nanning, 530021, PR ChinaCorrespondence author at Department of Biology, College of Science, Shantou University, Shantou, Guangdong, PR China 515063.; Department of Biology, College of Science, Shantou University, Shantou, 515063, PR China; Institute of Marine Sciences, Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, 515063, PR China; STU-UMT Joint Shellfish Research Laboratory, Shantou University, Shantou, 515063, PR ChinaGlutamate has been widely used in the feed industry to promote animal growth and enhance meat quality. However, its application in crustacean aquaculture remains relatively underexplored. In this study, we demonstrate a correlation between plasma glutamate increased the total hemocyte counts in shrimp within two hours, an effect that was reversed by co-injection with a Grik2 inhibitor. Subsequent feeding trials showed that incorporating 0.25 % glutamate into shrimp diets significantly raised the glutamate concentration in muscle tissue, resulting in a 7 % increase in glutamate content. Moreover, feeding experiments combined with differential transcriptome analysis revealed that shrimp fed a diet supplemented with 0.25 % glutamate exhibited enhanced resistance to Vibrio infections, likely through the upregulation of immune-related genes. These findings suggest that glutamate not only improves the anti-Vibrio defenses of shrimp but also enhances their flavor profile. Therefore, glutamate could serve as a beneficial feed supplement to promote disease resistance in shrimp aquaculture.http://www.sciencedirect.com/science/article/pii/S2950311625000102GlutamateLitopenaeus vannameiCellular immunityHippo pathway |
| spellingShingle | Lei Ma Wenyong Jiang Zhiyao Lu Yanmei Tong Qingyun Liu Zhonghua He Xiuli Chen Yongzhen Zhao Fan Wang Glutamate enhances shrimp antibacterial ability by boosting its cellular immunity Comparative Immunology Reports Glutamate Litopenaeus vannamei Cellular immunity Hippo pathway |
| title | Glutamate enhances shrimp antibacterial ability by boosting its cellular immunity |
| title_full | Glutamate enhances shrimp antibacterial ability by boosting its cellular immunity |
| title_fullStr | Glutamate enhances shrimp antibacterial ability by boosting its cellular immunity |
| title_full_unstemmed | Glutamate enhances shrimp antibacterial ability by boosting its cellular immunity |
| title_short | Glutamate enhances shrimp antibacterial ability by boosting its cellular immunity |
| title_sort | glutamate enhances shrimp antibacterial ability by boosting its cellular immunity |
| topic | Glutamate Litopenaeus vannamei Cellular immunity Hippo pathway |
| url | http://www.sciencedirect.com/science/article/pii/S2950311625000102 |
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