The Loss of YTHDC1 in Gut Macrophages Exacerbates Inflammatory Bowel Disease

The Loss of YTHDC1 in Gut Macrophages Exacerbates Inflammatory Bowel Disease

Abstract The nuclear N6‐methyladenosine (m6A) reader YT521‐B homology‐domain‐containing protein 1 (YTHDC1) is required to maintain embryonic stem cell identity. However, little is known about its biological functions in intestinal‐resident macrophages and inflammatory bowel disease (IBD). Herein, it...

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Bibliographic Details
Main Authors: Xuejun Ge, Gang Xue, Yan Ding, Ran Li, Kaining Hu, Tengjiao Xu, Ming Sun, Wang Liao, Bin Zhao, Chuangyu Wen, Jie Du
Format: Article
Language:English
Published: Wiley 2023-05-01
Series:Advanced Science
Subjects:
inflammatory bowel disease
macrophage
Nme1
Rhoh
YTHDC1
Online Access:https://doi.org/10.1002/advs.202205620
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