The investigation of sodium nitrite effects on the toxicokinetics of cyanide and thiocyanate
This study was carried out to determine the effects of sodium nitrites on some toxicoklnetic parameters of cyanide and thiocyanate in sheep experimentally poisoned with amygdalin In this study, 18 sheep 50 — 60 kg weights were used. Amygdalin and sodium nitrite were given and the cyanide a...
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| author | Sadettin Tanyıldızı İbrahim Pirinçci Sezai Kaya Emine Baydan |
| author_facet | Sadettin Tanyıldızı İbrahim Pirinçci Sezai Kaya Emine Baydan |
| author_sort | Sadettin Tanyıldızı |
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| description | This study was carried out to determine the effects of sodium nitrites on some toxicoklnetic parameters of cyanide and thiocyanate in sheep experimentally poisoned with amygdalin In this study, 18 sheep 50 — 60 kg weights were used. Amygdalin and sodium nitrite were given and the cyanide and thiocyanate levels in samples were determined Then some toxicokinetic parameters of the cyanide and thiocyanate in the blood samples taken at 0.5, 1, 2, 4, 8, 24, 48 and 72<sup>th</sup> hours were established. The sodium nitrite was given intravenously in doses 5 and 25 mg/kg and then the distribution half-lives of blood cyanide levels according to doses were respectively, 0.23±0.01 and 3.14±1.65 hours; the elimination half-lives were respectively, 60.80±13.41 and 126±24.33 hours; mean residence times were respectively, 88±10.04 and 185±2S.21 hours; the duration of maximal concentration were respectively, 48<sup>th</sup> hour; the maximal blood levels were respectively, 0.151 and 0148 µg/ml were determined. Besides, area under the curve values were according to doses were respectively, 11.28±1.24 and 9±S.62 µg.hour/ml; volume of distribution at steady state were respectively, 0.03±0.001 and 0.2±0.03 L/kg; clearance values were respectively, 0.44+0.12 and 0.16±0.09 ml/hour.kg were calculated. The distribution half-lives of blood thiocyanate levels according to doses were respectively, 18.30±2.21 and 29.44±3.41 hours; the elimination half-lives were respectively, 224.43±11.40 and 42.89±8.85 hours; mean residence times were respectively, 137.36±24.2 and 64.38±6.6S hours; the duration of maximal concentration were respectively, 24 and 48<sup>th</sup> hours; the maximal blood levels were respectively, 0.026 and 0.028 µg/ml were detennined. Besides, area under the curve values according to doses were respectively, 4.66±0.21 and 9.82±0.8 µg.hour/ml; volume of distribution at steady state were respectively, 0.147±0.03 and 0.162±0.03 L/kg; clearance values were respectively, 1.07+0.31 and 7.72±2.84 ml/hour.kg were established.. |
| format | Article |
| id | doaj-art-58d8aee9af92495d96bf81ca3676983a |
| institution | Kabale University |
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| spelling | doaj-art-58d8aee9af92495d96bf81ca3676983a2025-02-03T11:31:17ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-19531422126446The investigation of sodium nitrite effects on the toxicokinetics of cyanide and thiocyanateSadettin Tanyıldızı0İbrahim Pirinçci1Sezai Kaya2Emine Baydan3F.Ü. Veteriner Fakül tesi Farmakoloji ve Toksikoloji Anabilim Dalı, ELAZIĞF.Ü. Veteriner Fakül tesi Farmakoloji ve Toksikoloji Anabilim Dalı, ELAZIĞA.Ü. Veteriner Fakültesi Farmakoloji ve Toksikoloji Anabilim Dalı, ANKARAA.Ü. Veteriner Fakültesi Farmakoloji ve Toksikoloji Anabilim Dalı, ANKARAThis study was carried out to determine the effects of sodium nitrites on some toxicoklnetic parameters of cyanide and thiocyanate in sheep experimentally poisoned with amygdalin In this study, 18 sheep 50 — 60 kg weights were used. Amygdalin and sodium nitrite were given and the cyanide and thiocyanate levels in samples were determined Then some toxicokinetic parameters of the cyanide and thiocyanate in the blood samples taken at 0.5, 1, 2, 4, 8, 24, 48 and 72<sup>th</sup> hours were established. The sodium nitrite was given intravenously in doses 5 and 25 mg/kg and then the distribution half-lives of blood cyanide levels according to doses were respectively, 0.23±0.01 and 3.14±1.65 hours; the elimination half-lives were respectively, 60.80±13.41 and 126±24.33 hours; mean residence times were respectively, 88±10.04 and 185±2S.21 hours; the duration of maximal concentration were respectively, 48<sup>th</sup> hour; the maximal blood levels were respectively, 0.151 and 0148 µg/ml were determined. Besides, area under the curve values were according to doses were respectively, 11.28±1.24 and 9±S.62 µg.hour/ml; volume of distribution at steady state were respectively, 0.03±0.001 and 0.2±0.03 L/kg; clearance values were respectively, 0.44+0.12 and 0.16±0.09 ml/hour.kg were calculated. The distribution half-lives of blood thiocyanate levels according to doses were respectively, 18.30±2.21 and 29.44±3.41 hours; the elimination half-lives were respectively, 224.43±11.40 and 42.89±8.85 hours; mean residence times were respectively, 137.36±24.2 and 64.38±6.6S hours; the duration of maximal concentration were respectively, 24 and 48<sup>th</sup> hours; the maximal blood levels were respectively, 0.026 and 0.028 µg/ml were detennined. Besides, area under the curve values according to doses were respectively, 4.66±0.21 and 9.82±0.8 µg.hour/ml; volume of distribution at steady state were respectively, 0.147±0.03 and 0.162±0.03 L/kg; clearance values were respectively, 1.07+0.31 and 7.72±2.84 ml/hour.kg were established..http://eurasianjvetsci.org/pdf.php3?id=446cyanidethiocyanatesodium nitritetoxicokineticsheep |
| spellingShingle | Sadettin Tanyıldızı İbrahim Pirinçci Sezai Kaya Emine Baydan The investigation of sodium nitrite effects on the toxicokinetics of cyanide and thiocyanate Eurasian Journal of Veterinary Sciences cyanide thiocyanate sodium nitrite toxicokinetic sheep |
| title | The investigation of sodium nitrite effects on the toxicokinetics of cyanide and thiocyanate |
| title_full | The investigation of sodium nitrite effects on the toxicokinetics of cyanide and thiocyanate |
| title_fullStr | The investigation of sodium nitrite effects on the toxicokinetics of cyanide and thiocyanate |
| title_full_unstemmed | The investigation of sodium nitrite effects on the toxicokinetics of cyanide and thiocyanate |
| title_short | The investigation of sodium nitrite effects on the toxicokinetics of cyanide and thiocyanate |
| title_sort | investigation of sodium nitrite effects on the toxicokinetics of cyanide and thiocyanate |
| topic | cyanide thiocyanate sodium nitrite toxicokinetic sheep |
| url | http://eurasianjvetsci.org/pdf.php3?id=446 |
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