Nitric oxide inhibits ten-eleven translocation DNA demethylases to regulate 5mC and 5hmC across the genome

Nitric oxide inhibits ten-eleven translocation DNA demethylases to regulate 5mC and 5hmC across the genome

Abstract DNA methylation at cytosine bases (5-methylcytosine, 5mC) is a heritable epigenetic mark regulating gene expression. While enzymes that metabolize 5mC are well-characterized, endogenous signaling molecules that regulate DNA methylation machinery have not been described. We report that physi...

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Bibliographic Details
Main Authors: Marianne B. Palczewski, Hannah Petraitis Kuschman, Brian M. Hoffman, Venkatesan Kathiresan, Hao Yang, Sharon A. Glynn, David L. Wilson, Eric T. Kool, William R. Montfort, Jenny Chang, Aydolun Petenkaya, Constantinos Chronis, Thomas R. Cundari, Sushma Sappa, Kabirul Islam, Daniel W. McVicar, Yu Fan, Qingrong Chen, Daoud Meerzaman, Michael Sierk, Douglas D. Thomas
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56928-1
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