The Influence of Heavy Metals and Trace Elements on Comatose Patients with Severe Traumatic Brain Injury in the First Week of Admission
Purpose. The aim of this study is to investigate the possible role of heavy metals (lead and cadmium) and imbalance of trace elements (chromium, iron, zinc, copper, and manganese) in death among patients with severe traumatic brain injury. Material and Methods. A case-control study was conducted wit...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2018/7252606 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832555109484068864 |
|---|---|
| author | Bahia Belatar Abdallah Elabidi Malika Barkiyou Mamoun El Faroudi Rachid Eljaoudi Laila Lahlou Saad Kabbaj Wajdi Maazouzi |
| author_facet | Bahia Belatar Abdallah Elabidi Malika Barkiyou Mamoun El Faroudi Rachid Eljaoudi Laila Lahlou Saad Kabbaj Wajdi Maazouzi |
| author_sort | Bahia Belatar |
| collection | DOAJ |
| description | Purpose. The aim of this study is to investigate the possible role of heavy metals (lead and cadmium) and imbalance of trace elements (chromium, iron, zinc, copper, and manganese) in death among patients with severe traumatic brain injury. Material and Methods. A case-control study was conducted with 64 comatose patients with severe TBI, in the Department of Anesthesiology and Reanimation, Ibn Sina University Hospital and Hospital of Specialties in Rabat, Morocco; 22 healthy volunteers were recruited in Blood Transfusion Center of Rabat. Blood samples were collected from TBI patients, in the first week (3h after admission and each 48h during one week) and from healthy volunteers one time. Concentration of heavy metals and trace elements in serum was determined by electrochemical atomic absorption spectrometry. Statistical analysis was performed using Statistical software (SPSS) and the cases and controls were compared using the Mann–Whitney U test and Student’s t-test for cadmium according to gender and final evolution. A P-value <0.05 was considered to be statistically significant. Results. Our data showed that the difference of heavy metals concentration (lead and cadmium) between patients and healthy subjects was not statistically significant. However, the difference of some trace elements concentration (iron, copper, chromium, and selenium) between patients and healthy subjects was statistically significant. According to the final evolution, the concentration of manganese was higher in dead patients and statistically significant (p = 0.04) for heavy metals; the concentration of lead was not statistically significant while the concentration in cadmium was statistically significant (p = 0.004). By sex, lead and cadmium were statistically significant, respectively p = 0.02, p = 0.001, and cadmium was higher in women, while lead was higher in men. Conclusion. Among all studied heavy metals (lead and cadmium) and trace elements (iron, zinc, copper, selenium, chromium, and manganese), manganese and cadmium may play a role in the death of patients from severe traumatic brain injury. |
| format | Article |
| id | doaj-art-58bcdfd9e9984a4eb02ed93e0ff13e53 |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-58bcdfd9e9984a4eb02ed93e0ff13e532025-02-03T05:49:36ZengWileyJournal of Toxicology1687-81911687-82052018-01-01201810.1155/2018/72526067252606The Influence of Heavy Metals and Trace Elements on Comatose Patients with Severe Traumatic Brain Injury in the First Week of AdmissionBahia Belatar0Abdallah Elabidi1Malika Barkiyou2Mamoun El Faroudi3Rachid Eljaoudi4Laila Lahlou5Saad Kabbaj6Wajdi Maazouzi7Research Unit of Cerebral Monitoring in Neuro-Reanimation, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, MoroccoDepartment of Toxicology, National Institute of Health, Rabat, MoroccoLaboratory of Histology, Embryology and Cytogenetic, Faculty of Medicine and Pharmacy, University Mohammed V and Emergency and Intensive Care Unit, Ibn Sina Hospital, Rabat, MoroccoService of Anesthesiology and Reanimation, Ibn Sina University Hospital, Rabat, MoroccoPharmacology and Toxicology Department, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, MoroccoDepartment of Social Medicine, Epidemiology & Public Health, Faculty of Medicine and Pharmacy, Rabat, MoroccoResearch Unit of Cerebral Monitoring in Neuro-Reanimation, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, MoroccoResearch Unit of Cerebral Monitoring in Neuro-Reanimation, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, MoroccoPurpose. The aim of this study is to investigate the possible role of heavy metals (lead and cadmium) and imbalance of trace elements (chromium, iron, zinc, copper, and manganese) in death among patients with severe traumatic brain injury. Material and Methods. A case-control study was conducted with 64 comatose patients with severe TBI, in the Department of Anesthesiology and Reanimation, Ibn Sina University Hospital and Hospital of Specialties in Rabat, Morocco; 22 healthy volunteers were recruited in Blood Transfusion Center of Rabat. Blood samples were collected from TBI patients, in the first week (3h after admission and each 48h during one week) and from healthy volunteers one time. Concentration of heavy metals and trace elements in serum was determined by electrochemical atomic absorption spectrometry. Statistical analysis was performed using Statistical software (SPSS) and the cases and controls were compared using the Mann–Whitney U test and Student’s t-test for cadmium according to gender and final evolution. A P-value <0.05 was considered to be statistically significant. Results. Our data showed that the difference of heavy metals concentration (lead and cadmium) between patients and healthy subjects was not statistically significant. However, the difference of some trace elements concentration (iron, copper, chromium, and selenium) between patients and healthy subjects was statistically significant. According to the final evolution, the concentration of manganese was higher in dead patients and statistically significant (p = 0.04) for heavy metals; the concentration of lead was not statistically significant while the concentration in cadmium was statistically significant (p = 0.004). By sex, lead and cadmium were statistically significant, respectively p = 0.02, p = 0.001, and cadmium was higher in women, while lead was higher in men. Conclusion. Among all studied heavy metals (lead and cadmium) and trace elements (iron, zinc, copper, selenium, chromium, and manganese), manganese and cadmium may play a role in the death of patients from severe traumatic brain injury.http://dx.doi.org/10.1155/2018/7252606 |
| spellingShingle | Bahia Belatar Abdallah Elabidi Malika Barkiyou Mamoun El Faroudi Rachid Eljaoudi Laila Lahlou Saad Kabbaj Wajdi Maazouzi The Influence of Heavy Metals and Trace Elements on Comatose Patients with Severe Traumatic Brain Injury in the First Week of Admission Journal of Toxicology |
| title | The Influence of Heavy Metals and Trace Elements on Comatose Patients with Severe Traumatic Brain Injury in the First Week of Admission |
| title_full | The Influence of Heavy Metals and Trace Elements on Comatose Patients with Severe Traumatic Brain Injury in the First Week of Admission |
| title_fullStr | The Influence of Heavy Metals and Trace Elements on Comatose Patients with Severe Traumatic Brain Injury in the First Week of Admission |
| title_full_unstemmed | The Influence of Heavy Metals and Trace Elements on Comatose Patients with Severe Traumatic Brain Injury in the First Week of Admission |
| title_short | The Influence of Heavy Metals and Trace Elements on Comatose Patients with Severe Traumatic Brain Injury in the First Week of Admission |
| title_sort | influence of heavy metals and trace elements on comatose patients with severe traumatic brain injury in the first week of admission |
| url | http://dx.doi.org/10.1155/2018/7252606 |
| work_keys_str_mv | AT bahiabelatar theinfluenceofheavymetalsandtraceelementsoncomatosepatientswithseveretraumaticbraininjuryinthefirstweekofadmission AT abdallahelabidi theinfluenceofheavymetalsandtraceelementsoncomatosepatientswithseveretraumaticbraininjuryinthefirstweekofadmission AT malikabarkiyou theinfluenceofheavymetalsandtraceelementsoncomatosepatientswithseveretraumaticbraininjuryinthefirstweekofadmission AT mamounelfaroudi theinfluenceofheavymetalsandtraceelementsoncomatosepatientswithseveretraumaticbraininjuryinthefirstweekofadmission AT rachideljaoudi theinfluenceofheavymetalsandtraceelementsoncomatosepatientswithseveretraumaticbraininjuryinthefirstweekofadmission AT lailalahlou theinfluenceofheavymetalsandtraceelementsoncomatosepatientswithseveretraumaticbraininjuryinthefirstweekofadmission AT saadkabbaj theinfluenceofheavymetalsandtraceelementsoncomatosepatientswithseveretraumaticbraininjuryinthefirstweekofadmission AT wajdimaazouzi theinfluenceofheavymetalsandtraceelementsoncomatosepatientswithseveretraumaticbraininjuryinthefirstweekofadmission AT bahiabelatar influenceofheavymetalsandtraceelementsoncomatosepatientswithseveretraumaticbraininjuryinthefirstweekofadmission AT abdallahelabidi influenceofheavymetalsandtraceelementsoncomatosepatientswithseveretraumaticbraininjuryinthefirstweekofadmission AT malikabarkiyou influenceofheavymetalsandtraceelementsoncomatosepatientswithseveretraumaticbraininjuryinthefirstweekofadmission AT mamounelfaroudi influenceofheavymetalsandtraceelementsoncomatosepatientswithseveretraumaticbraininjuryinthefirstweekofadmission AT rachideljaoudi influenceofheavymetalsandtraceelementsoncomatosepatientswithseveretraumaticbraininjuryinthefirstweekofadmission AT lailalahlou influenceofheavymetalsandtraceelementsoncomatosepatientswithseveretraumaticbraininjuryinthefirstweekofadmission AT saadkabbaj influenceofheavymetalsandtraceelementsoncomatosepatientswithseveretraumaticbraininjuryinthefirstweekofadmission AT wajdimaazouzi influenceofheavymetalsandtraceelementsoncomatosepatientswithseveretraumaticbraininjuryinthefirstweekofadmission |