Update on the Medical Management of Gastrointestinal Behçet’s Disease
Behçet’s disease (BD) is a multisystemic disorder of unknown etiology mainly defined by recurrent oral aphthosis, genital ulcers, and chronic relapsing bilateral uveitis, all of which represent the “stigmata” of disease. However, many other organs including the vascular, neurological, musculoskeleta...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/1460491 |
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| author | Giuseppe Lopalco Donato Rigante Vincenzo Venerito Claudia Fabiani Rossella Franceschini Michele Barone Giovanni Lapadula Mauro Galeazzi Bruno Frediani Florenzo Iannone Luca Cantarini |
| author_facet | Giuseppe Lopalco Donato Rigante Vincenzo Venerito Claudia Fabiani Rossella Franceschini Michele Barone Giovanni Lapadula Mauro Galeazzi Bruno Frediani Florenzo Iannone Luca Cantarini |
| author_sort | Giuseppe Lopalco |
| collection | DOAJ |
| description | Behçet’s disease (BD) is a multisystemic disorder of unknown etiology mainly defined by recurrent oral aphthosis, genital ulcers, and chronic relapsing bilateral uveitis, all of which represent the “stigmata” of disease. However, many other organs including the vascular, neurological, musculoskeletal, and gastrointestinal systems can be affected. The gastrointestinal involvement in Behçet’s disease (GIBD), along with the neurological and vascular ones, represents the most feared clinical manifestation of BD and shares many symptoms with inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis. Consequently, the differential diagnosis is often a daunting task, albeit the presence of typical endoscopic and pathologic findings may be a valuable aid to the exact diagnosis. To date, there are no standardized medical treatments for GIBD; therefore therapy should be tailored to the single patient and based on the severity of the clinical features and their complications. This work provides a digest of all current experience and evidence about pharmacological agents suggested by the medical literature as having a potential role for managing the dreadful features of GIBD. |
| format | Article |
| id | doaj-art-58b0ca1217634365b5f667c27d34bab3 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-58b0ca1217634365b5f667c27d34bab32025-02-03T07:25:17ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/14604911460491Update on the Medical Management of Gastrointestinal Behçet’s DiseaseGiuseppe Lopalco0Donato Rigante1Vincenzo Venerito2Claudia Fabiani3Rossella Franceschini4Michele Barone5Giovanni Lapadula6Mauro Galeazzi7Bruno Frediani8Florenzo Iannone9Luca Cantarini10Department of Emergency and Organ Transplantation, Rheumatology Unit, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, ItalyInstitute of Pediatrics, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli, Largo A. Gemelli 8, 00168 Rome, ItalyDepartment of Emergency and Organ Transplantation, Rheumatology Unit, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, ItalyDepartment of Ophthalmology, Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano, 20089 Milan, ItalyOphthalmology and Neurosurgery Department, University of Siena, Viale Bracci 1, 53100 Siena, ItalySection of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation, Rheumatology Unit, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, ItalyResearch Center of Systemic Autoinflammatory Diseases and Behçet’s Disease Clinic, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Viale Bracci 1, 53100 Siena, ItalyResearch Center of Systemic Autoinflammatory Diseases and Behçet’s Disease Clinic, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Viale Bracci 1, 53100 Siena, ItalyDepartment of Emergency and Organ Transplantation, Rheumatology Unit, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, ItalyResearch Center of Systemic Autoinflammatory Diseases and Behçet’s Disease Clinic, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Viale Bracci 1, 53100 Siena, ItalyBehçet’s disease (BD) is a multisystemic disorder of unknown etiology mainly defined by recurrent oral aphthosis, genital ulcers, and chronic relapsing bilateral uveitis, all of which represent the “stigmata” of disease. However, many other organs including the vascular, neurological, musculoskeletal, and gastrointestinal systems can be affected. The gastrointestinal involvement in Behçet’s disease (GIBD), along with the neurological and vascular ones, represents the most feared clinical manifestation of BD and shares many symptoms with inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis. Consequently, the differential diagnosis is often a daunting task, albeit the presence of typical endoscopic and pathologic findings may be a valuable aid to the exact diagnosis. To date, there are no standardized medical treatments for GIBD; therefore therapy should be tailored to the single patient and based on the severity of the clinical features and their complications. This work provides a digest of all current experience and evidence about pharmacological agents suggested by the medical literature as having a potential role for managing the dreadful features of GIBD.http://dx.doi.org/10.1155/2017/1460491 |
| spellingShingle | Giuseppe Lopalco Donato Rigante Vincenzo Venerito Claudia Fabiani Rossella Franceschini Michele Barone Giovanni Lapadula Mauro Galeazzi Bruno Frediani Florenzo Iannone Luca Cantarini Update on the Medical Management of Gastrointestinal Behçet’s Disease Mediators of Inflammation |
| title | Update on the Medical Management of Gastrointestinal Behçet’s Disease |
| title_full | Update on the Medical Management of Gastrointestinal Behçet’s Disease |
| title_fullStr | Update on the Medical Management of Gastrointestinal Behçet’s Disease |
| title_full_unstemmed | Update on the Medical Management of Gastrointestinal Behçet’s Disease |
| title_short | Update on the Medical Management of Gastrointestinal Behçet’s Disease |
| title_sort | update on the medical management of gastrointestinal behcet s disease |
| url | http://dx.doi.org/10.1155/2017/1460491 |
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