Aryl hydrocarbon receptor facilitates HSV-1 lytic infection by enhancing viral gene transcription and receptor expression

Aryl hydrocarbon receptor facilitates HSV-1 lytic infection by enhancing viral gene transcription and receptor expression

Herpes simplex virus type 1 (HSV-1) is a major human pathogen with significant morbidity in neonates and immunocompromised individuals. However, antiviral drugs targeting HSV-1 are emerging with antiviral resistance, highlighting the need to identify new targets for future treatment. Once HSV-1 ente...

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Bibliographic Details
Main Authors: Pu Huang, Xiaohong Pan, Hongli Chen, Mengyue Lei, Ying Ma, Xiaomei Guo, Jiaxin Xie, Jixiong Li, Jing Sun, Yunzhang Hu, Jiandong Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
HSV-1
lytic infection
AhR
host factor
antiviral target
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1548038/full
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