Coactivators in PPAR-Regulated Gene Expression
Peroxisome proliferator-activated receptor (PPAR)α, β (also known as δ), and γ function as sensors for fatty acids and fatty acid derivatives and control important metabolic pathways involved in the maintenance of energy balance. PPARs also regulate other diverse biological processes such as develop...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2010/250126 |
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| author | Navin Viswakarma Yuzhi Jia Liang Bai Aurore Vluggens Jayme Borensztajn Jianming Xu Janardan K. Reddy |
| author_facet | Navin Viswakarma Yuzhi Jia Liang Bai Aurore Vluggens Jayme Borensztajn Jianming Xu Janardan K. Reddy |
| author_sort | Navin Viswakarma |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptor (PPAR)α, β (also known as δ), and γ function as sensors for fatty acids and fatty acid derivatives and control important metabolic pathways involved in the maintenance of energy balance. PPARs also regulate other diverse biological processes such as development, differentiation, inflammation, and neoplasia. In the nucleus, PPARs exist as heterodimers with retinoid X receptor-α bound to DNA with corepressor molecules. Upon ligand activation, PPARs undergo conformational changes that facilitate the dissociation of corepressor molecules and invoke a spatiotemporally orchestrated recruitment of transcription cofactors including coactivators and coactivator-associated proteins. While a given nuclear receptor regulates the expression of a prescribed set of target genes, coactivators are likely to influence the functioning of many regulators and thus affect the transcription of many genes. Evidence suggests that some of the coactivators such as PPAR-binding protein (PBP/PPARBP)/thyroid hormone receptor-associated protein 220 (TRAP220)/mediator complex subunit 1 (MED1) may exert a broader influence on the functions of several nuclear receptors and their target genes. Investigations into the role of coactivators in the function of PPARs should strengthen our understanding of the complexities of metabolic diseases associated with energy metabolism. |
| format | Article |
| id | doaj-art-588c92cd2f764b638ba5637278897293 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-588c92cd2f764b638ba56372788972932025-02-03T06:05:57ZengWileyPPAR Research1687-47571687-47652010-01-01201010.1155/2010/250126250126Coactivators in PPAR-Regulated Gene ExpressionNavin Viswakarma0Yuzhi Jia1Liang Bai2Aurore Vluggens3Jayme Borensztajn4Jianming Xu5Janardan K. Reddy6Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USADepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USADepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USADepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USADepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USADepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USADepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USAPeroxisome proliferator-activated receptor (PPAR)α, β (also known as δ), and γ function as sensors for fatty acids and fatty acid derivatives and control important metabolic pathways involved in the maintenance of energy balance. PPARs also regulate other diverse biological processes such as development, differentiation, inflammation, and neoplasia. In the nucleus, PPARs exist as heterodimers with retinoid X receptor-α bound to DNA with corepressor molecules. Upon ligand activation, PPARs undergo conformational changes that facilitate the dissociation of corepressor molecules and invoke a spatiotemporally orchestrated recruitment of transcription cofactors including coactivators and coactivator-associated proteins. While a given nuclear receptor regulates the expression of a prescribed set of target genes, coactivators are likely to influence the functioning of many regulators and thus affect the transcription of many genes. Evidence suggests that some of the coactivators such as PPAR-binding protein (PBP/PPARBP)/thyroid hormone receptor-associated protein 220 (TRAP220)/mediator complex subunit 1 (MED1) may exert a broader influence on the functions of several nuclear receptors and their target genes. Investigations into the role of coactivators in the function of PPARs should strengthen our understanding of the complexities of metabolic diseases associated with energy metabolism.http://dx.doi.org/10.1155/2010/250126 |
| spellingShingle | Navin Viswakarma Yuzhi Jia Liang Bai Aurore Vluggens Jayme Borensztajn Jianming Xu Janardan K. Reddy Coactivators in PPAR-Regulated Gene Expression PPAR Research |
| title | Coactivators in PPAR-Regulated Gene Expression |
| title_full | Coactivators in PPAR-Regulated Gene Expression |
| title_fullStr | Coactivators in PPAR-Regulated Gene Expression |
| title_full_unstemmed | Coactivators in PPAR-Regulated Gene Expression |
| title_short | Coactivators in PPAR-Regulated Gene Expression |
| title_sort | coactivators in ppar regulated gene expression |
| url | http://dx.doi.org/10.1155/2010/250126 |
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