BCG-Induced Trained Immunity in Healthy Individuals: The Effect of Plasma Muramyl Dipeptide Concentrations
BCG vaccination protects not only against tuberculosis but also against heterologous infections. This effect differs between individuals, yet the factors responsible for this variation are unknown. BCG-induced nonspecific protection is, at least partially, mediated by innate immune reprogramming (tr...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/5812743 |
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| author | Vera P. Mourits Valerie A. C. M. Koeken L. Charlotte J. de Bree Simone J. C. F. M. Moorlag Wern Cui Chu Xiaoli Xu Helga Dijkstra Heidi Lemmers Leo A. B. Joosten Yue Wang Reinout van Crevel Mihai G. Netea |
| author_facet | Vera P. Mourits Valerie A. C. M. Koeken L. Charlotte J. de Bree Simone J. C. F. M. Moorlag Wern Cui Chu Xiaoli Xu Helga Dijkstra Heidi Lemmers Leo A. B. Joosten Yue Wang Reinout van Crevel Mihai G. Netea |
| author_sort | Vera P. Mourits |
| collection | DOAJ |
| description | BCG vaccination protects not only against tuberculosis but also against heterologous infections. This effect differs between individuals, yet the factors responsible for this variation are unknown. BCG-induced nonspecific protection is, at least partially, mediated by innate immune reprogramming (trained immunity), which can be induced by the muramyl dipeptide (MDP) component of peptidoglycans. We aimed to study whether differential release of MDP in healthy individuals may explain variability of their response to BCG vaccination. Circulating MDP concentrations were increased up to three months after BCG vaccination. MDP concentrations at baseline, but not their increase postvaccination, positively correlated with the induction of trained immunity and not with mycobacteria-induced T-cell responses. Interestingly, MDP concentrations correlated with inflammatory markers in the circulation. In conclusion, circulating MDP concentrations are associated with the strength of trained immunity responses and thus influence the biological effects of BCG vaccination. This study increases our understanding about the role of MDP in BCG-induced trained immunity, which might help to optimize vaccine efficacy and explore novel applications of BCG vaccination. |
| format | Article |
| id | doaj-art-58896731c6ec463baa60fcef2646f1d7 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-58896731c6ec463baa60fcef2646f1d72025-02-03T06:45:48ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/58127435812743BCG-Induced Trained Immunity in Healthy Individuals: The Effect of Plasma Muramyl Dipeptide ConcentrationsVera P. Mourits0Valerie A. C. M. Koeken1L. Charlotte J. de Bree2Simone J. C. F. M. Moorlag3Wern Cui Chu4Xiaoli Xu5Helga Dijkstra6Heidi Lemmers7Leo A. B. Joosten8Yue Wang9Reinout van Crevel10Mihai G. Netea11Department of Internal Medicine, Radboud Institute of Molecular Life Sciences (RIMLS) and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6525 Nijmegen, NetherlandsDepartment of Internal Medicine, Radboud Institute of Molecular Life Sciences (RIMLS) and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6525 Nijmegen, NetherlandsDepartment of Internal Medicine, Radboud Institute of Molecular Life Sciences (RIMLS) and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6525 Nijmegen, NetherlandsDepartment of Internal Medicine, Radboud Institute of Molecular Life Sciences (RIMLS) and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6525 Nijmegen, NetherlandsInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research, Queenstown, 138673, SingaporeInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research, Queenstown, 138673, SingaporeDepartment of Internal Medicine, Radboud Institute of Molecular Life Sciences (RIMLS) and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6525 Nijmegen, NetherlandsDepartment of Internal Medicine, Radboud Institute of Molecular Life Sciences (RIMLS) and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6525 Nijmegen, NetherlandsDepartment of Internal Medicine, Radboud Institute of Molecular Life Sciences (RIMLS) and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6525 Nijmegen, NetherlandsInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research, Queenstown, 138673, SingaporeDepartment of Internal Medicine, Radboud Institute of Molecular Life Sciences (RIMLS) and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6525 Nijmegen, NetherlandsDepartment of Internal Medicine, Radboud Institute of Molecular Life Sciences (RIMLS) and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6525 Nijmegen, NetherlandsBCG vaccination protects not only against tuberculosis but also against heterologous infections. This effect differs between individuals, yet the factors responsible for this variation are unknown. BCG-induced nonspecific protection is, at least partially, mediated by innate immune reprogramming (trained immunity), which can be induced by the muramyl dipeptide (MDP) component of peptidoglycans. We aimed to study whether differential release of MDP in healthy individuals may explain variability of their response to BCG vaccination. Circulating MDP concentrations were increased up to three months after BCG vaccination. MDP concentrations at baseline, but not their increase postvaccination, positively correlated with the induction of trained immunity and not with mycobacteria-induced T-cell responses. Interestingly, MDP concentrations correlated with inflammatory markers in the circulation. In conclusion, circulating MDP concentrations are associated with the strength of trained immunity responses and thus influence the biological effects of BCG vaccination. This study increases our understanding about the role of MDP in BCG-induced trained immunity, which might help to optimize vaccine efficacy and explore novel applications of BCG vaccination.http://dx.doi.org/10.1155/2020/5812743 |
| spellingShingle | Vera P. Mourits Valerie A. C. M. Koeken L. Charlotte J. de Bree Simone J. C. F. M. Moorlag Wern Cui Chu Xiaoli Xu Helga Dijkstra Heidi Lemmers Leo A. B. Joosten Yue Wang Reinout van Crevel Mihai G. Netea BCG-Induced Trained Immunity in Healthy Individuals: The Effect of Plasma Muramyl Dipeptide Concentrations Journal of Immunology Research |
| title | BCG-Induced Trained Immunity in Healthy Individuals: The Effect of Plasma Muramyl Dipeptide Concentrations |
| title_full | BCG-Induced Trained Immunity in Healthy Individuals: The Effect of Plasma Muramyl Dipeptide Concentrations |
| title_fullStr | BCG-Induced Trained Immunity in Healthy Individuals: The Effect of Plasma Muramyl Dipeptide Concentrations |
| title_full_unstemmed | BCG-Induced Trained Immunity in Healthy Individuals: The Effect of Plasma Muramyl Dipeptide Concentrations |
| title_short | BCG-Induced Trained Immunity in Healthy Individuals: The Effect of Plasma Muramyl Dipeptide Concentrations |
| title_sort | bcg induced trained immunity in healthy individuals the effect of plasma muramyl dipeptide concentrations |
| url | http://dx.doi.org/10.1155/2020/5812743 |
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