ANCA-Associated Vasculitic Neuropathy: A Case Report
Anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitides (AAVs) are a group of autoimmune diseases that can affect many vital organs and tissues, as well as the nervous system. When peripheral nerves are affected, one of the clinical features of AAVs can be vasculitic neuropathies (VNs...
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| Language: | English |
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Vilnius University Press
2023-11-01
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| Series: | Neurologijos seminarai |
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| Online Access: | https://www.journals.vu.lt/neurologijos_seminarai/article/view/33567 |
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| author | M. Jakiševaitė I. Navickaitė G. Žemgulytė |
| author_facet | M. Jakiševaitė I. Navickaitė G. Žemgulytė |
| author_sort | M. Jakiševaitė |
| collection | DOAJ |
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Anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitides (AAVs) are a group of autoimmune diseases that can affect many vital organs and tissues, as well as the nervous system. When peripheral nerves are affected, one of the clinical features of AAVs can be vasculitic neuropathies (VNs). This usually causes asymmetric weakness and numbness in the distal parts of extremities, frequently followed by pain. Nerve conduction study (NCS) reveals axonal loss in multiple individual nerves, whereas a length-dependent process may also be observed. As AAV is a rare diagnostic entity and can manifest with a vast variety of symptoms, it is seldom involved in the initial diagnostic work-up of polyneuropathy. Moreover, the only definitive diagnostic method for VN is peripheral nerve biopsy. Therefore, AAV represents one of the greatest difficulties in the differential diagnosis of neuropathies. In this article, we present a clinical case of a 73-year-old patient admitted to the hospital due to blurry vision, headache, and limb weakness. The findings of the neurological examination were consistent with polyneuropathy. A thorough examination was performed to determine the exact diagnosis. However, due to the lack of typical symptoms, VN was diagnosed only after acute renal failure evolved. This case demonstrates the many symptoms that AAV can present with and the importance of a thorough differential diagnosis for multiple mononeuropathies.
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| format | Article |
| id | doaj-art-586636a0e9034374bdb814ab0e6cb88b |
| institution | Kabale University |
| issn | 1392-3064 2424-5917 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | Vilnius University Press |
| record_format | Article |
| series | Neurologijos seminarai |
| spelling | doaj-art-586636a0e9034374bdb814ab0e6cb88b2025-01-20T18:22:02ZengVilnius University PressNeurologijos seminarai1392-30642424-59172023-11-0127No. 1 (95)10.29014/NS.2023.27.7ANCA-Associated Vasculitic Neuropathy: A Case ReportM. Jakiševaitė0I. Navickaitė1G. Žemgulytė2Lithuanian University of Health SciencesLithuanian University of Health SciencesLithuanian University of Health Sciences Anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitides (AAVs) are a group of autoimmune diseases that can affect many vital organs and tissues, as well as the nervous system. When peripheral nerves are affected, one of the clinical features of AAVs can be vasculitic neuropathies (VNs). This usually causes asymmetric weakness and numbness in the distal parts of extremities, frequently followed by pain. Nerve conduction study (NCS) reveals axonal loss in multiple individual nerves, whereas a length-dependent process may also be observed. As AAV is a rare diagnostic entity and can manifest with a vast variety of symptoms, it is seldom involved in the initial diagnostic work-up of polyneuropathy. Moreover, the only definitive diagnostic method for VN is peripheral nerve biopsy. Therefore, AAV represents one of the greatest difficulties in the differential diagnosis of neuropathies. In this article, we present a clinical case of a 73-year-old patient admitted to the hospital due to blurry vision, headache, and limb weakness. The findings of the neurological examination were consistent with polyneuropathy. A thorough examination was performed to determine the exact diagnosis. However, due to the lack of typical symptoms, VN was diagnosed only after acute renal failure evolved. This case demonstrates the many symptoms that AAV can present with and the importance of a thorough differential diagnosis for multiple mononeuropathies. https://www.journals.vu.lt/neurologijos_seminarai/article/view/33567ANCA-associated vasculitismicroscopic polyangiitismultiple mononeuropathiesvasculitic neuropathies |
| spellingShingle | M. Jakiševaitė I. Navickaitė G. Žemgulytė ANCA-Associated Vasculitic Neuropathy: A Case Report Neurologijos seminarai ANCA-associated vasculitis microscopic polyangiitis multiple mononeuropathies vasculitic neuropathies |
| title | ANCA-Associated Vasculitic Neuropathy: A Case Report |
| title_full | ANCA-Associated Vasculitic Neuropathy: A Case Report |
| title_fullStr | ANCA-Associated Vasculitic Neuropathy: A Case Report |
| title_full_unstemmed | ANCA-Associated Vasculitic Neuropathy: A Case Report |
| title_short | ANCA-Associated Vasculitic Neuropathy: A Case Report |
| title_sort | anca associated vasculitic neuropathy a case report |
| topic | ANCA-associated vasculitis microscopic polyangiitis multiple mononeuropathies vasculitic neuropathies |
| url | https://www.journals.vu.lt/neurologijos_seminarai/article/view/33567 |
| work_keys_str_mv | AT mjakisevaite ancaassociatedvasculiticneuropathyacasereport AT inavickaite ancaassociatedvasculiticneuropathyacasereport AT gzemgulyte ancaassociatedvasculiticneuropathyacasereport |