Depression as a risk factor for osteoporosis independent of sarcopenia in hemodialysis patients: findings from a multicenter cross-sectional study
Abstract Background Osteoporosis and sarcopenia frequently occur in patients with end-stage renal disease undergoing hemodialysis (HD), and depression is also a common mental health issue in this population. Despite the prevalence of these conditions, the interrelationships among them remain poorly...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12882-025-03963-1 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832585987625058304 |
|---|---|
| author | Xiaohua Hu Xianwu Ye Haimin Chen Bibo Wu Qi Guo Chen Yu Wei Ding Jianying Niu Junli Zhao Hualin Qi Suhua Zhang Cheng Xue Liming Zhang |
| author_facet | Xiaohua Hu Xianwu Ye Haimin Chen Bibo Wu Qi Guo Chen Yu Wei Ding Jianying Niu Junli Zhao Hualin Qi Suhua Zhang Cheng Xue Liming Zhang |
| author_sort | Xiaohua Hu |
| collection | DOAJ |
| description | Abstract Background Osteoporosis and sarcopenia frequently occur in patients with end-stage renal disease undergoing hemodialysis (HD), and depression is also a common mental health issue in this population. Despite the prevalence of these conditions, the interrelationships among them remain poorly understood in HD patients. Methods In this multicenter cross-sectional study, 858 HD patients from 7 dialysis centers were recruited. Bone mineral density (BMD) was assessed using dual-energy X-ray absorptiometry. Skeletal muscle mass index (SMI) was calculated from body composition data obtained through multifrequency bioimpedance analysis (BIA), while handgrip strength (HGS) was measured with a dynamometer. Gait speed was evaluated with a 4-meter walk test, and depression was assessed using the Patient Health Questionnaire-9 (PHQ-9). Results Among the 858 participants (524 men, 334 women), 39.2% had osteoporosis. The prevalence of sarcopenia and depression was 18.9% and 42.1%, respectively. Logistic regression analysis showed that SMI was significantly associated with a decreased risk of osteoporosis (OR = 0.638, 95% CI = 0.494–0.823, P = 0.001), while HGS was not(OR = 0.990, 95% CI = 0.963–1.017, P = 0.449). HD patients with sarcopenia were 1.92 times more likely to have osteoporosis than those without sarcopenia. Most notably, after adjusting for both sarcopenia and SMI, the risk of osteoporosis in HD patients with depression was 1.45 times higher than in those without depression (OR = 1.452, 95% CI = 1.060–1.989, P = 0.020). Conclusions In HD patients, increased muscle mass, rather than muscle strength, is linked to a lower risk of osteoporosis. Notably, depression emerges as a significant risk factor for osteoporosis in this population, highlighting the need for mental health considerations in managing bone health. |
| format | Article |
| id | doaj-art-5863f0384e5741438a5be9a2802edf64 |
| institution | Kabale University |
| issn | 1471-2369 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj-art-5863f0384e5741438a5be9a2802edf642025-01-26T12:19:39ZengBMCBMC Nephrology1471-23692025-01-0126111110.1186/s12882-025-03963-1Depression as a risk factor for osteoporosis independent of sarcopenia in hemodialysis patients: findings from a multicenter cross-sectional studyXiaohua Hu0Xianwu Ye1Haimin Chen2Bibo Wu3Qi Guo4Chen Yu5Wei Ding6Jianying Niu7Junli Zhao8Hualin Qi9Suhua Zhang10Cheng Xue11Liming Zhang12Department of Nephrology, Zhabei Central Hospital of Jing’an DistrictDepartment of Nephrology, Zhabei Central Hospital of Jing’an DistrictDepartment of Hematology and Oncology, Zhabei Central Hospital of Jing’an DistrictDepartment of Nephrology, Zhabei Central Hospital of Jing’an DistrictDepartment of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu HospitalDepartment of Nephrology, Tongji Hospital School of Medicine, Tongji UniversityDepartment of Nephrology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Nephrology, The Fifth People’s Hospital of Shanghai, Fudan UniversityDepartment of Nephrology, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu HospitalDepartment of Nephrology, Shanghai Pudong New Area People’s HospitalDepartment of Nephrology, Suzhou Kowloon Hospital, Shanghai Jiaotong University School of MedicineDepartment of Nephrology, Shanghai Changzheng Hospital, Second Military Medical University (Naval Medical University)Department of Nephrology, Zhabei Central Hospital of Jing’an DistrictAbstract Background Osteoporosis and sarcopenia frequently occur in patients with end-stage renal disease undergoing hemodialysis (HD), and depression is also a common mental health issue in this population. Despite the prevalence of these conditions, the interrelationships among them remain poorly understood in HD patients. Methods In this multicenter cross-sectional study, 858 HD patients from 7 dialysis centers were recruited. Bone mineral density (BMD) was assessed using dual-energy X-ray absorptiometry. Skeletal muscle mass index (SMI) was calculated from body composition data obtained through multifrequency bioimpedance analysis (BIA), while handgrip strength (HGS) was measured with a dynamometer. Gait speed was evaluated with a 4-meter walk test, and depression was assessed using the Patient Health Questionnaire-9 (PHQ-9). Results Among the 858 participants (524 men, 334 women), 39.2% had osteoporosis. The prevalence of sarcopenia and depression was 18.9% and 42.1%, respectively. Logistic regression analysis showed that SMI was significantly associated with a decreased risk of osteoporosis (OR = 0.638, 95% CI = 0.494–0.823, P = 0.001), while HGS was not(OR = 0.990, 95% CI = 0.963–1.017, P = 0.449). HD patients with sarcopenia were 1.92 times more likely to have osteoporosis than those without sarcopenia. Most notably, after adjusting for both sarcopenia and SMI, the risk of osteoporosis in HD patients with depression was 1.45 times higher than in those without depression (OR = 1.452, 95% CI = 1.060–1.989, P = 0.020). Conclusions In HD patients, increased muscle mass, rather than muscle strength, is linked to a lower risk of osteoporosis. Notably, depression emerges as a significant risk factor for osteoporosis in this population, highlighting the need for mental health considerations in managing bone health.https://doi.org/10.1186/s12882-025-03963-1SarcopeniaDepressionOsteoporosisHemodialysisBone mineral density |
| spellingShingle | Xiaohua Hu Xianwu Ye Haimin Chen Bibo Wu Qi Guo Chen Yu Wei Ding Jianying Niu Junli Zhao Hualin Qi Suhua Zhang Cheng Xue Liming Zhang Depression as a risk factor for osteoporosis independent of sarcopenia in hemodialysis patients: findings from a multicenter cross-sectional study BMC Nephrology Sarcopenia Depression Osteoporosis Hemodialysis Bone mineral density |
| title | Depression as a risk factor for osteoporosis independent of sarcopenia in hemodialysis patients: findings from a multicenter cross-sectional study |
| title_full | Depression as a risk factor for osteoporosis independent of sarcopenia in hemodialysis patients: findings from a multicenter cross-sectional study |
| title_fullStr | Depression as a risk factor for osteoporosis independent of sarcopenia in hemodialysis patients: findings from a multicenter cross-sectional study |
| title_full_unstemmed | Depression as a risk factor for osteoporosis independent of sarcopenia in hemodialysis patients: findings from a multicenter cross-sectional study |
| title_short | Depression as a risk factor for osteoporosis independent of sarcopenia in hemodialysis patients: findings from a multicenter cross-sectional study |
| title_sort | depression as a risk factor for osteoporosis independent of sarcopenia in hemodialysis patients findings from a multicenter cross sectional study |
| topic | Sarcopenia Depression Osteoporosis Hemodialysis Bone mineral density |
| url | https://doi.org/10.1186/s12882-025-03963-1 |
| work_keys_str_mv | AT xiaohuahu depressionasariskfactorforosteoporosisindependentofsarcopeniainhemodialysispatientsfindingsfromamulticentercrosssectionalstudy AT xianwuye depressionasariskfactorforosteoporosisindependentofsarcopeniainhemodialysispatientsfindingsfromamulticentercrosssectionalstudy AT haiminchen depressionasariskfactorforosteoporosisindependentofsarcopeniainhemodialysispatientsfindingsfromamulticentercrosssectionalstudy AT bibowu depressionasariskfactorforosteoporosisindependentofsarcopeniainhemodialysispatientsfindingsfromamulticentercrosssectionalstudy AT qiguo depressionasariskfactorforosteoporosisindependentofsarcopeniainhemodialysispatientsfindingsfromamulticentercrosssectionalstudy AT chenyu depressionasariskfactorforosteoporosisindependentofsarcopeniainhemodialysispatientsfindingsfromamulticentercrosssectionalstudy AT weiding depressionasariskfactorforosteoporosisindependentofsarcopeniainhemodialysispatientsfindingsfromamulticentercrosssectionalstudy AT jianyingniu depressionasariskfactorforosteoporosisindependentofsarcopeniainhemodialysispatientsfindingsfromamulticentercrosssectionalstudy AT junlizhao depressionasariskfactorforosteoporosisindependentofsarcopeniainhemodialysispatientsfindingsfromamulticentercrosssectionalstudy AT hualinqi depressionasariskfactorforosteoporosisindependentofsarcopeniainhemodialysispatientsfindingsfromamulticentercrosssectionalstudy AT suhuazhang depressionasariskfactorforosteoporosisindependentofsarcopeniainhemodialysispatientsfindingsfromamulticentercrosssectionalstudy AT chengxue depressionasariskfactorforosteoporosisindependentofsarcopeniainhemodialysispatientsfindingsfromamulticentercrosssectionalstudy AT limingzhang depressionasariskfactorforosteoporosisindependentofsarcopeniainhemodialysispatientsfindingsfromamulticentercrosssectionalstudy |