Dupuytren's Contracture Cosegregation with Limb-Girdle Muscle Dystrophy
Limb-girdle muscular dystrophies (LGMDs) is a heterogeneous group of muscular dystrophies that mostly affect the pelvic and shoulder girdle muscle groups. We report here a case of neuromuscular disease associated with Dupuytren's contracture, which has never been described before as cosegregati...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/254950 |
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| Summary: | Limb-girdle muscular dystrophies (LGMDs) is a heterogeneous group of muscular
dystrophies that mostly affect the pelvic and shoulder girdle muscle groups. We report
here a case of neuromuscular disease associated with Dupuytren's contracture, which
has never been described before as cosegregating with an autosomal dominant type
of inheritance. Dupuytren's contracture is a common disease, especially in Northern
Europe. Comorbid conditions associated with Dupuytren's contracture are repetitive
trauma to the hands, diabetes, and seizures, but it has never before been associated
with neuromuscular disease. We hypothesize that patients may harbor mutations in
genes with functions related to neuromuscular disease and Dupuytren's contracture
development. |
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| ISSN: | 2090-6668 2090-6676 |