NIR‐II Fluorescent Protein Created by In Situ Albumin‐Tagging for Sensitive and Specific Imaging of Blood‐Brain Barrier Disruption

NIR‐II Fluorescent Protein Created by In Situ Albumin‐Tagging for Sensitive and Specific Imaging of Blood‐Brain Barrier Disruption

Abstract Imaging albumin in vivo is a reliable strategy to visualize blood‐brain barrier (BBB) disruption by detecting the dye‐labeled albumin leaking into brain parenchyma. Although Evans Blue (EB) and indocyanine green (ICG) dyes have been applied to assess BBB impairment, their naked‐eye observat...

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Bibliographic Details
Main Authors: Jiajun Xu, Yijing Du, Ningning Zhu, Jia Li, Yuewei Zhang, Ding Zhou, Shoujun Zhu
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
blood‐brain barrier disruption imaging
covalent binding
cyanine dye
in situ albumin‐tagging
NIR‐II fluorescent protein
Online Access:https://doi.org/10.1002/advs.202500443
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