Plasma Adiponectin and Its Correlation with Carotid Intima-Media Thickness in Obesity and in Type 2 Diabetes and Nonalcoholic Fatty Liver Disease
Background and Aim. Low plasma adiponectin has been found in both obese subjects and patients with type 2 diabetes mellitus (T2DM). Also, it was reported in patients with nonalcoholic fatty liver disease (NAFLD). We assessed plasma adiponectin and its correlation with carotid intima-media thickness...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2023/6661585 |
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| author | Maha Hussein Aasem Saif Mona Amin Osama Khalafallah Ahmed Hussien Samar Aboulsoud Shrook Mousa |
| author_facet | Maha Hussein Aasem Saif Mona Amin Osama Khalafallah Ahmed Hussien Samar Aboulsoud Shrook Mousa |
| author_sort | Maha Hussein |
| collection | DOAJ |
| description | Background and Aim. Low plasma adiponectin has been found in both obese subjects and patients with type 2 diabetes mellitus (T2DM). Also, it was reported in patients with nonalcoholic fatty liver disease (NAFLD). We assessed plasma adiponectin and its correlation with carotid intima-media thickness (CIMT), as a marker of atherosclerosis, in Egyptian patients with NAFLD. Methods and Results. The study included 200 Egyptian subjects. They were divided into four equal groups: group 1: obese patients with NAFLD and T2DM (O+/NAFLD+/DM+), group 2: nonobese patients with NAFLD and T2DM (O-/NAFLD+/DM+), group 3: obese nondiabetic patients with NAFLD (O+/NAFLD+/DM-), and group 4: nonobese healthy control subjects. Plasma adiponectin was measured using ELISA (enzyme-linked immunosorbent assay) technique. Ultrasonography was used to diagnose NAFLD. CIMT was assessed using Doppler ultrasonography. Plasma adiponectin was significantly lower and CIMT was significantly higher in O+/NAFLD+/DM+, as compared with O-/NAFLD+/DM+, O+/NAFLD+/DM-, and control subjects (p<0.001 for all). A significant negative correlation was found between adiponectin and CIMT in obese patients with NAFLD (p<0.05), but not in patients with NAFLD and T2DM. The significant independent predictors of CIMT were diabetes duration, BMI (body mass index), albumin/creatinine ratio, and cholesterol. Conclusion. Plasma adiponectin is inversely correlated with CIMT in obese patients with NAFLD, but not in patients with NAFLD and T2DM. Hypoadiponectinemia could be a good indicator of cardiovascular risk in obese patients with NAFLD, with or without T2DM, but not in nonobese patients with NAFLD. |
| format | Article |
| id | doaj-art-585b0eec5be44f9dacfa6a8158af595f |
| institution | Kabale University |
| issn | 2090-0732 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-585b0eec5be44f9dacfa6a8158af595f2025-02-03T06:42:53ZengWileyJournal of Nutrition and Metabolism2090-07322023-01-01202310.1155/2023/6661585Plasma Adiponectin and Its Correlation with Carotid Intima-Media Thickness in Obesity and in Type 2 Diabetes and Nonalcoholic Fatty Liver DiseaseMaha Hussein0Aasem Saif1Mona Amin2Osama Khalafallah3Ahmed Hussien4Samar Aboulsoud5Shrook Mousa6Internal Medicine DepartmentInternal Medicine DepartmentInternal Medicine DepartmentClinical and Chemical Pathology DepartmentInternal Medicine DepartmentInternal Medicine DepartmentInternal Medicine DepartmentBackground and Aim. Low plasma adiponectin has been found in both obese subjects and patients with type 2 diabetes mellitus (T2DM). Also, it was reported in patients with nonalcoholic fatty liver disease (NAFLD). We assessed plasma adiponectin and its correlation with carotid intima-media thickness (CIMT), as a marker of atherosclerosis, in Egyptian patients with NAFLD. Methods and Results. The study included 200 Egyptian subjects. They were divided into four equal groups: group 1: obese patients with NAFLD and T2DM (O+/NAFLD+/DM+), group 2: nonobese patients with NAFLD and T2DM (O-/NAFLD+/DM+), group 3: obese nondiabetic patients with NAFLD (O+/NAFLD+/DM-), and group 4: nonobese healthy control subjects. Plasma adiponectin was measured using ELISA (enzyme-linked immunosorbent assay) technique. Ultrasonography was used to diagnose NAFLD. CIMT was assessed using Doppler ultrasonography. Plasma adiponectin was significantly lower and CIMT was significantly higher in O+/NAFLD+/DM+, as compared with O-/NAFLD+/DM+, O+/NAFLD+/DM-, and control subjects (p<0.001 for all). A significant negative correlation was found between adiponectin and CIMT in obese patients with NAFLD (p<0.05), but not in patients with NAFLD and T2DM. The significant independent predictors of CIMT were diabetes duration, BMI (body mass index), albumin/creatinine ratio, and cholesterol. Conclusion. Plasma adiponectin is inversely correlated with CIMT in obese patients with NAFLD, but not in patients with NAFLD and T2DM. Hypoadiponectinemia could be a good indicator of cardiovascular risk in obese patients with NAFLD, with or without T2DM, but not in nonobese patients with NAFLD.http://dx.doi.org/10.1155/2023/6661585 |
| spellingShingle | Maha Hussein Aasem Saif Mona Amin Osama Khalafallah Ahmed Hussien Samar Aboulsoud Shrook Mousa Plasma Adiponectin and Its Correlation with Carotid Intima-Media Thickness in Obesity and in Type 2 Diabetes and Nonalcoholic Fatty Liver Disease Journal of Nutrition and Metabolism |
| title | Plasma Adiponectin and Its Correlation with Carotid Intima-Media Thickness in Obesity and in Type 2 Diabetes and Nonalcoholic Fatty Liver Disease |
| title_full | Plasma Adiponectin and Its Correlation with Carotid Intima-Media Thickness in Obesity and in Type 2 Diabetes and Nonalcoholic Fatty Liver Disease |
| title_fullStr | Plasma Adiponectin and Its Correlation with Carotid Intima-Media Thickness in Obesity and in Type 2 Diabetes and Nonalcoholic Fatty Liver Disease |
| title_full_unstemmed | Plasma Adiponectin and Its Correlation with Carotid Intima-Media Thickness in Obesity and in Type 2 Diabetes and Nonalcoholic Fatty Liver Disease |
| title_short | Plasma Adiponectin and Its Correlation with Carotid Intima-Media Thickness in Obesity and in Type 2 Diabetes and Nonalcoholic Fatty Liver Disease |
| title_sort | plasma adiponectin and its correlation with carotid intima media thickness in obesity and in type 2 diabetes and nonalcoholic fatty liver disease |
| url | http://dx.doi.org/10.1155/2023/6661585 |
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