The Mechanism of Physical Exercise Activates the Mechanistic Target Signaling Pathway of Rapamycin in Mice as a Trigger for Cell Proliferation: A Systematic Review
The goal of this research is to examine the benefits of physical activity for increasing mechanistic target of rapamycin (mTOR) as a trigger for muscle hypertrophy through the process of cell proliferation from a physiological point of view. In this systematic review investigation, literature databa...
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| Format: | Article |
| Language: | English |
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Romanian Association of Balneology, Editura Balneara
2025-06-01
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| Series: | Balneo and PRM Research Journal |
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| Online Access: | https://bioclima.ro/Balneo819.pdf |
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| author | Hamdani Anton Komaini Junian Cahyanto Wibawa Joseph Lobo Ainun Zulfikar Rizki Alvin Afandi Dwi Lorry Juniarisca Bambang Ferianto Tjahyo Kuntjoro Muchamad Arif Al Ardha Novadri Ayubi |
| author_facet | Hamdani Anton Komaini Junian Cahyanto Wibawa Joseph Lobo Ainun Zulfikar Rizki Alvin Afandi Dwi Lorry Juniarisca Bambang Ferianto Tjahyo Kuntjoro Muchamad Arif Al Ardha Novadri Ayubi |
| author_sort | Hamdani |
| collection | DOAJ |
| description | The goal of this research is to examine the benefits of physical activity for increasing mechanistic target of rapamycin (mTOR) as a trigger for muscle hypertrophy through the process of cell proliferation from a physiological point of view. In this systematic review investigation, literature databases such as MEDLINE-Pubmed, Web of Science, Scopus, and Science Direct were searched. Papers that discussed physical exercise, the mechanis-tic target of rapamycin (mTOR), and were published during the previous five years met the inclusion criteria. 96 published publications were located using the Science Direct, Pubmed, and Web of Science databases. Seven papers that satisfied the inclusion criteria were ultimately chosen and reviewed for this systematic review. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) were used in this study to as-sess the standard operating procedures. According to this systematic study, exercise has been proven to raise mTOR. Re-sistance training has a higher potential to increase mTOR than aerobic training. Exercise has been shown to raise the phosphorylation of mTOR in cells. Evidence suggests that an increase in mTOR after physical exercise can trigger muscle hypertrophy through the process of cell proliferation. Physical exercise is obvious-ly a good effort in maintaining muscle to avoid the mechanism of muscle atrophy, espe-cially related to age and several metabolic syndrome diseases. |
| format | Article |
| id | doaj-art-58582d9b80f549c29d2415df059fcda2 |
| institution | Kabale University |
| issn | 2734-8458 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Romanian Association of Balneology, Editura Balneara |
| record_format | Article |
| series | Balneo and PRM Research Journal |
| spelling | doaj-art-58582d9b80f549c29d2415df059fcda22025-08-20T03:51:18ZengRomanian Association of Balneology, Editura BalnearaBalneo and PRM Research Journal2734-84582025-06-0116281910.12680/balneo.2025.819The Mechanism of Physical Exercise Activates the Mechanistic Target Signaling Pathway of Rapamycin in Mice as a Trigger for Cell Proliferation: A Systematic ReviewHamdani0Anton Komaini 1Junian Cahyanto Wibawa 2Joseph Lobo 3Ainun Zulfikar Rizki4Alvin Afandi 5Dwi Lorry Juniarisca 6Bambang Ferianto Tjahyo Kuntjoro 7Muchamad Arif Al Ardha 8Novadri Ayubi 9Universitas Negeri Surabaya, Surabaya IndonesiaUniversitas Negeri Padang, Padang IndonesiaSTKIP PGRI Trenggalek, Trenggalek, IndonesiaBulacan State University, Malolos, PhilippinesUniversitas Negeri Surabaya, Surabaya IndonesiaUniversitas Negeri Surabaya, Surabaya IndonesiaUniversitas Negeri Surabaya, Surabaya IndonesiaUniversitas Negeri Surabaya, Surabaya IndonesiaUniversitas Negeri Surabaya, Surabaya IndonesiaUniversitas Negeri Surabaya, Surabaya IndonesiaThe goal of this research is to examine the benefits of physical activity for increasing mechanistic target of rapamycin (mTOR) as a trigger for muscle hypertrophy through the process of cell proliferation from a physiological point of view. In this systematic review investigation, literature databases such as MEDLINE-Pubmed, Web of Science, Scopus, and Science Direct were searched. Papers that discussed physical exercise, the mechanis-tic target of rapamycin (mTOR), and were published during the previous five years met the inclusion criteria. 96 published publications were located using the Science Direct, Pubmed, and Web of Science databases. Seven papers that satisfied the inclusion criteria were ultimately chosen and reviewed for this systematic review. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) were used in this study to as-sess the standard operating procedures. According to this systematic study, exercise has been proven to raise mTOR. Re-sistance training has a higher potential to increase mTOR than aerobic training. Exercise has been shown to raise the phosphorylation of mTOR in cells. Evidence suggests that an increase in mTOR after physical exercise can trigger muscle hypertrophy through the process of cell proliferation. Physical exercise is obvious-ly a good effort in maintaining muscle to avoid the mechanism of muscle atrophy, espe-cially related to age and several metabolic syndrome diseases.https://bioclima.ro/Balneo819.pdfmtorphysical exercisehypertrophyproliferation |
| spellingShingle | Hamdani Anton Komaini Junian Cahyanto Wibawa Joseph Lobo Ainun Zulfikar Rizki Alvin Afandi Dwi Lorry Juniarisca Bambang Ferianto Tjahyo Kuntjoro Muchamad Arif Al Ardha Novadri Ayubi The Mechanism of Physical Exercise Activates the Mechanistic Target Signaling Pathway of Rapamycin in Mice as a Trigger for Cell Proliferation: A Systematic Review Balneo and PRM Research Journal mtor physical exercise hypertrophy proliferation |
| title | The Mechanism of Physical Exercise Activates the Mechanistic Target Signaling Pathway of Rapamycin in Mice as a Trigger for Cell Proliferation: A Systematic Review |
| title_full | The Mechanism of Physical Exercise Activates the Mechanistic Target Signaling Pathway of Rapamycin in Mice as a Trigger for Cell Proliferation: A Systematic Review |
| title_fullStr | The Mechanism of Physical Exercise Activates the Mechanistic Target Signaling Pathway of Rapamycin in Mice as a Trigger for Cell Proliferation: A Systematic Review |
| title_full_unstemmed | The Mechanism of Physical Exercise Activates the Mechanistic Target Signaling Pathway of Rapamycin in Mice as a Trigger for Cell Proliferation: A Systematic Review |
| title_short | The Mechanism of Physical Exercise Activates the Mechanistic Target Signaling Pathway of Rapamycin in Mice as a Trigger for Cell Proliferation: A Systematic Review |
| title_sort | mechanism of physical exercise activates the mechanistic target signaling pathway of rapamycin in mice as a trigger for cell proliferation a systematic review |
| topic | mtor physical exercise hypertrophy proliferation |
| url | https://bioclima.ro/Balneo819.pdf |
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