N-acetyltransferase 2 Slow Acetylator Genotype Associated with Adverse Effects of Sulfasalazine in the Treatment of Inflammatory Bowel Disease
AIM: N-acetyltransferase 2 (NAT2) is an important enzyme catalyzing N-acetylation of sulfasalazine (SASP). The aim of the present study was to investigate associations of the genotypes of NAT2 with inflammatory bowel disease (IBD), and with adverse effects of SASP, which is used as the first-line tr...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2007-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2007/976804 |
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| _version_ | 1832564606986354688 |
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| author | Min Chen Bing Xia Bixiao Chen Qiusha Guo Jin Li Mei Ye Zhengguo Hu |
| author_facet | Min Chen Bing Xia Bixiao Chen Qiusha Guo Jin Li Mei Ye Zhengguo Hu |
| author_sort | Min Chen |
| collection | DOAJ |
| description | AIM: N-acetyltransferase 2 (NAT2) is an important enzyme catalyzing N-acetylation of sulfasalazine (SASP). The aim of the present study was to investigate associations of the genotypes of NAT2 with inflammatory bowel disease (IBD), and with adverse effects of SASP, which is used as the first-line treatment of IBD. |
| format | Article |
| id | doaj-art-584866c7003940839bb01735aefa7fae |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-584866c7003940839bb01735aefa7fae2025-02-03T01:10:41ZengWileyCanadian Journal of Gastroenterology0835-79002007-01-0121315515810.1155/2007/976804N-acetyltransferase 2 Slow Acetylator Genotype Associated with Adverse Effects of Sulfasalazine in the Treatment of Inflammatory Bowel DiseaseMin Chen0Bing Xia1Bixiao Chen2Qiusha Guo3Jin Li4Mei Ye5Zhengguo Hu6Research Center of Digestive Diseases, ChinaResearch Center of Digestive Diseases, ChinaKey Laboratory of Allergy and Immune-Related Diseases, School of Medicine, Wuhan University, ChinaKey Laboratory of Allergy and Immune-Related Diseases, School of Medicine, Wuhan University, ChinaResearch Center of Digestive Diseases, ChinaDepartments of Internal Medicine and Geriatrics, Wuhan University Zhongnan Hospital, Wuhan, ChinaDepartments of Internal Medicine and Geriatrics, Wuhan University Zhongnan Hospital, Wuhan, ChinaAIM: N-acetyltransferase 2 (NAT2) is an important enzyme catalyzing N-acetylation of sulfasalazine (SASP). The aim of the present study was to investigate associations of the genotypes of NAT2 with inflammatory bowel disease (IBD), and with adverse effects of SASP, which is used as the first-line treatment of IBD.http://dx.doi.org/10.1155/2007/976804 |
| spellingShingle | Min Chen Bing Xia Bixiao Chen Qiusha Guo Jin Li Mei Ye Zhengguo Hu N-acetyltransferase 2 Slow Acetylator Genotype Associated with Adverse Effects of Sulfasalazine in the Treatment of Inflammatory Bowel Disease Canadian Journal of Gastroenterology |
| title | N-acetyltransferase 2 Slow Acetylator Genotype Associated with Adverse Effects of Sulfasalazine in the Treatment of Inflammatory Bowel Disease |
| title_full | N-acetyltransferase 2 Slow Acetylator Genotype Associated with Adverse Effects of Sulfasalazine in the Treatment of Inflammatory Bowel Disease |
| title_fullStr | N-acetyltransferase 2 Slow Acetylator Genotype Associated with Adverse Effects of Sulfasalazine in the Treatment of Inflammatory Bowel Disease |
| title_full_unstemmed | N-acetyltransferase 2 Slow Acetylator Genotype Associated with Adverse Effects of Sulfasalazine in the Treatment of Inflammatory Bowel Disease |
| title_short | N-acetyltransferase 2 Slow Acetylator Genotype Associated with Adverse Effects of Sulfasalazine in the Treatment of Inflammatory Bowel Disease |
| title_sort | n acetyltransferase 2 slow acetylator genotype associated with adverse effects of sulfasalazine in the treatment of inflammatory bowel disease |
| url | http://dx.doi.org/10.1155/2007/976804 |
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