Factors Associated with the Prevalence of Thyroid Nodules and Goiter in Middle-Aged Euthyroid Subjects
The aim of the present study was to determine associations of thyroid hormone levels and different metabolic parameters and anthropometric measurements with volume of nodular and nonnodular thyroid as well as with prevalence of goiter and thyroid nodules in middle-aged euthyroid subjects. Methods. T...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/8401518 |
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| author | Dalia Dauksiene Janina Petkeviciene Jurate Klumbiene Rasa Verkauskiene Jelena Vainikonyte-Kristapone Audrone Seibokaite Jonas Ceponis Vygantas Sidlauskas Laura Daugintyte-Petrusiene Antanas Norkus Birute Zilaitiene |
| author_facet | Dalia Dauksiene Janina Petkeviciene Jurate Klumbiene Rasa Verkauskiene Jelena Vainikonyte-Kristapone Audrone Seibokaite Jonas Ceponis Vygantas Sidlauskas Laura Daugintyte-Petrusiene Antanas Norkus Birute Zilaitiene |
| author_sort | Dalia Dauksiene |
| collection | DOAJ |
| description | The aim of the present study was to determine associations of thyroid hormone levels and different metabolic parameters and anthropometric measurements with volume of nodular and nonnodular thyroid as well as with prevalence of goiter and thyroid nodules in middle-aged euthyroid subjects. Methods. The study consisted of 317 euthyroid subjects aged 48-49 from the Kaunas Cardiovascular Risk Cohort study. Thyroid-stimulating hormone (TSH), free thyroxine (FT4), and antithyroid peroxidase antibody (ATPO) levels, as well as anthropometric and metabolic parameters and smoking information, were evaluated. Results. In subjects with and without thyroid nodules, thyroid volume correlated with components of metabolic syndrome, body mass index (BMI), smoking, and TSH levels. In the nonnodular thyroid group, thyroid volume was also positively related to serum insulin and HOMA-IR, whereas a negative correlation between thyroid volume and leptin was identified in the nodular thyroid group. The goiter was identified in 12.3% of subjects. Female gender, thyroid nodules, smoking, BMI, and levels of TSH were independent predictors for goiter. Thyroid nodules were found in 31.2% of participants. Female gender, higher TSH levels, and thyroid volume were independent risk factors for thyroid nodules. Conclusions. Female gender, thyroid nodules, smoking, BMI, and TSH levels were identified as potential predictors of goiter. Female gender, TSH levels, and thyroid volume predicted the presence of thyroid nodules. |
| format | Article |
| id | doaj-art-583cc72ae8aa450c9be9ca7a4b573559 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-583cc72ae8aa450c9be9ca7a4b5735592025-02-03T05:44:41ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/84015188401518Factors Associated with the Prevalence of Thyroid Nodules and Goiter in Middle-Aged Euthyroid SubjectsDalia Dauksiene0Janina Petkeviciene1Jurate Klumbiene2Rasa Verkauskiene3Jelena Vainikonyte-Kristapone4Audrone Seibokaite5Jonas Ceponis6Vygantas Sidlauskas7Laura Daugintyte-Petrusiene8Antanas Norkus9Birute Zilaitiene10Institute of Endocrinology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaFaculty of Public Health, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaFaculty of Public Health, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaInstitute of Endocrinology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaDepartment of Endocrinology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaInstitute of Endocrinology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaInstitute of Endocrinology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaInstitute of Endocrinology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaDepartment of Endocrinology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaInstitute of Endocrinology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaInstitute of Endocrinology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaThe aim of the present study was to determine associations of thyroid hormone levels and different metabolic parameters and anthropometric measurements with volume of nodular and nonnodular thyroid as well as with prevalence of goiter and thyroid nodules in middle-aged euthyroid subjects. Methods. The study consisted of 317 euthyroid subjects aged 48-49 from the Kaunas Cardiovascular Risk Cohort study. Thyroid-stimulating hormone (TSH), free thyroxine (FT4), and antithyroid peroxidase antibody (ATPO) levels, as well as anthropometric and metabolic parameters and smoking information, were evaluated. Results. In subjects with and without thyroid nodules, thyroid volume correlated with components of metabolic syndrome, body mass index (BMI), smoking, and TSH levels. In the nonnodular thyroid group, thyroid volume was also positively related to serum insulin and HOMA-IR, whereas a negative correlation between thyroid volume and leptin was identified in the nodular thyroid group. The goiter was identified in 12.3% of subjects. Female gender, thyroid nodules, smoking, BMI, and levels of TSH were independent predictors for goiter. Thyroid nodules were found in 31.2% of participants. Female gender, higher TSH levels, and thyroid volume were independent risk factors for thyroid nodules. Conclusions. Female gender, thyroid nodules, smoking, BMI, and TSH levels were identified as potential predictors of goiter. Female gender, TSH levels, and thyroid volume predicted the presence of thyroid nodules.http://dx.doi.org/10.1155/2017/8401518 |
| spellingShingle | Dalia Dauksiene Janina Petkeviciene Jurate Klumbiene Rasa Verkauskiene Jelena Vainikonyte-Kristapone Audrone Seibokaite Jonas Ceponis Vygantas Sidlauskas Laura Daugintyte-Petrusiene Antanas Norkus Birute Zilaitiene Factors Associated with the Prevalence of Thyroid Nodules and Goiter in Middle-Aged Euthyroid Subjects International Journal of Endocrinology |
| title | Factors Associated with the Prevalence of Thyroid Nodules and Goiter in Middle-Aged Euthyroid Subjects |
| title_full | Factors Associated with the Prevalence of Thyroid Nodules and Goiter in Middle-Aged Euthyroid Subjects |
| title_fullStr | Factors Associated with the Prevalence of Thyroid Nodules and Goiter in Middle-Aged Euthyroid Subjects |
| title_full_unstemmed | Factors Associated with the Prevalence of Thyroid Nodules and Goiter in Middle-Aged Euthyroid Subjects |
| title_short | Factors Associated with the Prevalence of Thyroid Nodules and Goiter in Middle-Aged Euthyroid Subjects |
| title_sort | factors associated with the prevalence of thyroid nodules and goiter in middle aged euthyroid subjects |
| url | http://dx.doi.org/10.1155/2017/8401518 |
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