The Interactions between Insulin and Androgens in Progression to Castrate-Resistant Prostate Cancer
An association between the metabolic syndrome and reduced testosterone levels has been identified, and a specific inverse relationship between insulin and testosterone levels suggests that an important metabolic crosstalk exists between these two hormonal axes; however, the mechanisms by which insul...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Advances in Urology |
| Online Access: | http://dx.doi.org/10.1155/2012/248607 |
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| _version_ | 1832559970354200576 |
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| author | Jennifer H. Gunter Amy A. Lubik Ian McKenzie Michael Pollak Colleen C. Nelson |
| author_facet | Jennifer H. Gunter Amy A. Lubik Ian McKenzie Michael Pollak Colleen C. Nelson |
| author_sort | Jennifer H. Gunter |
| collection | DOAJ |
| description | An association between the metabolic syndrome and reduced testosterone levels has been identified, and a specific inverse relationship between insulin and testosterone levels suggests that an important metabolic crosstalk exists between these two hormonal axes; however, the mechanisms by which insulin and androgens may be reciprocally regulated are not well described. Androgen-dependant gene pathways regulate the growth and maintenance of both normal and malignant prostate tissue, and androgen-deprivation therapy (ADT) in patients exploits this dependence when used to treat recurrent and metastatic prostate cancer resulting in tumour regression. A major systemic side effect of ADT includes induction of key features of the metabolic syndrome and the consistent feature of hyperinsulinaemia. Recent studies have specifically identified a correlation between elevated insulin and high-grade PCa and more rapid progression to castrate resistant disease. This paper examines the relationship between insulin and androgens in the context of prostate cancer progression. Prostate cancer patients present a promising cohort for the exploration of insulin stabilising agents as adjunct treatments for hormone deprivation or enhancers of chemosensitivity for treatment of advanced prostate cancer. |
| format | Article |
| id | doaj-art-581c14910d814e238341a8dfb91ee4c7 |
| institution | Kabale University |
| issn | 1687-6369 1687-6377 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Urology |
| spelling | doaj-art-581c14910d814e238341a8dfb91ee4c72025-02-03T01:28:48ZengWileyAdvances in Urology1687-63691687-63772012-01-01201210.1155/2012/248607248607The Interactions between Insulin and Androgens in Progression to Castrate-Resistant Prostate CancerJennifer H. Gunter0Amy A. Lubik1Ian McKenzie2Michael Pollak3Colleen C. Nelson4Australian Prostate Cancer Research Centre-Queensland, Queensland University of Technology, Princess Alexandra Hospital, Level 1, Building 1, Ipswich Road, Brisbane, QLD 4102, AustraliaAustralian Prostate Cancer Research Centre-Queensland, Queensland University of Technology, Princess Alexandra Hospital, Level 1, Building 1, Ipswich Road, Brisbane, QLD 4102, AustraliaAustralian Prostate Cancer Research Centre-Queensland, Queensland University of Technology, Princess Alexandra Hospital, Level 1, Building 1, Ipswich Road, Brisbane, QLD 4102, AustraliaMcGill University, Jewish General Hospital, 3755 Côte-Sainte-Catherine Road, Room E-740, Montreal, QC, H3T 1E2, CanadaAustralian Prostate Cancer Research Centre-Queensland, Queensland University of Technology, Princess Alexandra Hospital, Level 1, Building 1, Ipswich Road, Brisbane, QLD 4102, AustraliaAn association between the metabolic syndrome and reduced testosterone levels has been identified, and a specific inverse relationship between insulin and testosterone levels suggests that an important metabolic crosstalk exists between these two hormonal axes; however, the mechanisms by which insulin and androgens may be reciprocally regulated are not well described. Androgen-dependant gene pathways regulate the growth and maintenance of both normal and malignant prostate tissue, and androgen-deprivation therapy (ADT) in patients exploits this dependence when used to treat recurrent and metastatic prostate cancer resulting in tumour regression. A major systemic side effect of ADT includes induction of key features of the metabolic syndrome and the consistent feature of hyperinsulinaemia. Recent studies have specifically identified a correlation between elevated insulin and high-grade PCa and more rapid progression to castrate resistant disease. This paper examines the relationship between insulin and androgens in the context of prostate cancer progression. Prostate cancer patients present a promising cohort for the exploration of insulin stabilising agents as adjunct treatments for hormone deprivation or enhancers of chemosensitivity for treatment of advanced prostate cancer.http://dx.doi.org/10.1155/2012/248607 |
| spellingShingle | Jennifer H. Gunter Amy A. Lubik Ian McKenzie Michael Pollak Colleen C. Nelson The Interactions between Insulin and Androgens in Progression to Castrate-Resistant Prostate Cancer Advances in Urology |
| title | The Interactions between Insulin and Androgens in Progression to Castrate-Resistant Prostate Cancer |
| title_full | The Interactions between Insulin and Androgens in Progression to Castrate-Resistant Prostate Cancer |
| title_fullStr | The Interactions between Insulin and Androgens in Progression to Castrate-Resistant Prostate Cancer |
| title_full_unstemmed | The Interactions between Insulin and Androgens in Progression to Castrate-Resistant Prostate Cancer |
| title_short | The Interactions between Insulin and Androgens in Progression to Castrate-Resistant Prostate Cancer |
| title_sort | interactions between insulin and androgens in progression to castrate resistant prostate cancer |
| url | http://dx.doi.org/10.1155/2012/248607 |
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