Can Thrifty Gene(s) or Predictive Fetal Programming for Thriftiness Lead to Obesity?
Obesity and related disorders are thought to have their roots in metabolic “thriftiness” that evolved to combat periodic starvation. The association of low birth weight with obesity in later life caused a shift in the concept from thrifty gene to thrifty phenotype or anticipatory fetal programming....
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2011/861049 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548118338469888 |
|---|---|
| author | Ulfat Baig Prajakta Belsare Milind Watve Maithili Jog |
| author_facet | Ulfat Baig Prajakta Belsare Milind Watve Maithili Jog |
| author_sort | Ulfat Baig |
| collection | DOAJ |
| description | Obesity and related disorders are thought to have their roots in metabolic “thriftiness” that evolved to combat periodic starvation. The association of low birth weight with obesity in later life caused a shift in the concept from thrifty gene to thrifty phenotype or anticipatory fetal programming. The assumption of thriftiness is implicit in obesity research. We examine here, with the help of a mathematical model, the conditions for evolution of thrifty genes or fetal programming for thriftiness. The model suggests that a thrifty gene cannot exist in a stable polymorphic state in a population. The conditions for evolution of thrifty fetal programming are restricted if the correlation between intrauterine and lifetime conditions is poor. Such a correlation is not observed in natural courses of famine. If there is fetal programming for thriftiness, it could have evolved in anticipation of social factors affecting nutrition that can result in a positive correlation. |
| format | Article |
| id | doaj-art-581983ed4dba4f90a8812f1f6aedbf5b |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-581983ed4dba4f90a8812f1f6aedbf5b2025-02-03T06:42:11ZengWileyJournal of Obesity2090-07082090-07162011-01-01201110.1155/2011/861049861049Can Thrifty Gene(s) or Predictive Fetal Programming for Thriftiness Lead to Obesity?Ulfat Baig0Prajakta Belsare1Milind Watve2Maithili Jog3Indian Institute of Science Education and Research, Pune 411021, IndiaIndian Institute of Science Education and Research, Pune 411021, IndiaIndian Institute of Science Education and Research, Pune 411021, IndiaDepartment of Biotechnology, Abasaheb Garware College, Pune 411004, IndiaObesity and related disorders are thought to have their roots in metabolic “thriftiness” that evolved to combat periodic starvation. The association of low birth weight with obesity in later life caused a shift in the concept from thrifty gene to thrifty phenotype or anticipatory fetal programming. The assumption of thriftiness is implicit in obesity research. We examine here, with the help of a mathematical model, the conditions for evolution of thrifty genes or fetal programming for thriftiness. The model suggests that a thrifty gene cannot exist in a stable polymorphic state in a population. The conditions for evolution of thrifty fetal programming are restricted if the correlation between intrauterine and lifetime conditions is poor. Such a correlation is not observed in natural courses of famine. If there is fetal programming for thriftiness, it could have evolved in anticipation of social factors affecting nutrition that can result in a positive correlation.http://dx.doi.org/10.1155/2011/861049 |
| spellingShingle | Ulfat Baig Prajakta Belsare Milind Watve Maithili Jog Can Thrifty Gene(s) or Predictive Fetal Programming for Thriftiness Lead to Obesity? Journal of Obesity |
| title | Can Thrifty Gene(s) or Predictive Fetal Programming for Thriftiness Lead to Obesity? |
| title_full | Can Thrifty Gene(s) or Predictive Fetal Programming for Thriftiness Lead to Obesity? |
| title_fullStr | Can Thrifty Gene(s) or Predictive Fetal Programming for Thriftiness Lead to Obesity? |
| title_full_unstemmed | Can Thrifty Gene(s) or Predictive Fetal Programming for Thriftiness Lead to Obesity? |
| title_short | Can Thrifty Gene(s) or Predictive Fetal Programming for Thriftiness Lead to Obesity? |
| title_sort | can thrifty gene s or predictive fetal programming for thriftiness lead to obesity |
| url | http://dx.doi.org/10.1155/2011/861049 |
| work_keys_str_mv | AT ulfatbaig canthriftygenesorpredictivefetalprogrammingforthriftinessleadtoobesity AT prajaktabelsare canthriftygenesorpredictivefetalprogrammingforthriftinessleadtoobesity AT milindwatve canthriftygenesorpredictivefetalprogrammingforthriftinessleadtoobesity AT maithilijog canthriftygenesorpredictivefetalprogrammingforthriftinessleadtoobesity |