Increased Accuracy of Emotion Recognition in Individuals with Autism-Like Traits after Five Days of Magnetic Stimulations
Individuals with autism-like traits (ALT) belong to a subclinical group with similar social deficits as autism spectrum disorders (ASD). Their main social deficits include atypical eye contact and difficulty in understanding facial expressions, both of which are associated with an abnormality of the...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2020/9857987 |
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| author | Pingping Liu Guixian Xiao Kongliang He Long Zhang Xinqi Wu Dandan Li Chunyan Zhu Yanghua Tian Panpan Hu Bensheng Qiu Gong-Jun Ji Kai Wang |
| author_facet | Pingping Liu Guixian Xiao Kongliang He Long Zhang Xinqi Wu Dandan Li Chunyan Zhu Yanghua Tian Panpan Hu Bensheng Qiu Gong-Jun Ji Kai Wang |
| author_sort | Pingping Liu |
| collection | DOAJ |
| description | Individuals with autism-like traits (ALT) belong to a subclinical group with similar social deficits as autism spectrum disorders (ASD). Their main social deficits include atypical eye contact and difficulty in understanding facial expressions, both of which are associated with an abnormality of the right posterior superior temporal sulcus (rpSTS). It is still undetermined whether it is possible to improve the social function of ALT individuals through noninvasive neural modulation. To this end, we randomly assigned ALT individuals into the real (n=16) and sham (n=16) stimulation groups. All subjects received five consecutive days of intermittent theta burst stimulation (iTBS) on the rpSTS. Eye tracking data and functional magnetic resonance imaging (fMRI) data were acquired on the first and sixth days. The real group showed significant improvement in emotion recognition accuracy after iTBS, but the change was not significantly larger than that in the sham group. Resting-state functional connectivity (rsFC) between the rpSTS and the left cerebellum significantly decreased in the real group than the sham group after iTBS. At baseline, rsFC in the left cerebellum was negatively correlated with emotion recognition accuracy. Our findings indicated that iTBS of the rpSTS could improve emotion perception of ALT individuals by modulating associated neural networks. This stimulation protocol could be a vital therapeutic strategy for the treatment of ASD. |
| format | Article |
| id | doaj-art-5817a8fc62904b53b9dd739e4bf4598d |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-5817a8fc62904b53b9dd739e4bf4598d2025-02-03T01:08:11ZengWileyNeural Plasticity2090-59041687-54432020-01-01202010.1155/2020/98579879857987Increased Accuracy of Emotion Recognition in Individuals with Autism-Like Traits after Five Days of Magnetic StimulationsPingping Liu0Guixian Xiao1Kongliang He2Long Zhang3Xinqi Wu4Dandan Li5Chunyan Zhu6Yanghua Tian7Panpan Hu8Bensheng Qiu9Gong-Jun Ji10Kai Wang11Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei 230000, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei 230000, ChinaThe Fourth People’s Hospital of Hefei, Hefei 230000, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei 230000, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei 230000, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei 230000, ChinaAnhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei 230032, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei 230000, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei 230000, ChinaCenters for Biomedical Engineering, University of Science and Technology of China, Hefei 230000, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei 230000, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei 230000, ChinaIndividuals with autism-like traits (ALT) belong to a subclinical group with similar social deficits as autism spectrum disorders (ASD). Their main social deficits include atypical eye contact and difficulty in understanding facial expressions, both of which are associated with an abnormality of the right posterior superior temporal sulcus (rpSTS). It is still undetermined whether it is possible to improve the social function of ALT individuals through noninvasive neural modulation. To this end, we randomly assigned ALT individuals into the real (n=16) and sham (n=16) stimulation groups. All subjects received five consecutive days of intermittent theta burst stimulation (iTBS) on the rpSTS. Eye tracking data and functional magnetic resonance imaging (fMRI) data were acquired on the first and sixth days. The real group showed significant improvement in emotion recognition accuracy after iTBS, but the change was not significantly larger than that in the sham group. Resting-state functional connectivity (rsFC) between the rpSTS and the left cerebellum significantly decreased in the real group than the sham group after iTBS. At baseline, rsFC in the left cerebellum was negatively correlated with emotion recognition accuracy. Our findings indicated that iTBS of the rpSTS could improve emotion perception of ALT individuals by modulating associated neural networks. This stimulation protocol could be a vital therapeutic strategy for the treatment of ASD.http://dx.doi.org/10.1155/2020/9857987 |
| spellingShingle | Pingping Liu Guixian Xiao Kongliang He Long Zhang Xinqi Wu Dandan Li Chunyan Zhu Yanghua Tian Panpan Hu Bensheng Qiu Gong-Jun Ji Kai Wang Increased Accuracy of Emotion Recognition in Individuals with Autism-Like Traits after Five Days of Magnetic Stimulations Neural Plasticity |
| title | Increased Accuracy of Emotion Recognition in Individuals with Autism-Like Traits after Five Days of Magnetic Stimulations |
| title_full | Increased Accuracy of Emotion Recognition in Individuals with Autism-Like Traits after Five Days of Magnetic Stimulations |
| title_fullStr | Increased Accuracy of Emotion Recognition in Individuals with Autism-Like Traits after Five Days of Magnetic Stimulations |
| title_full_unstemmed | Increased Accuracy of Emotion Recognition in Individuals with Autism-Like Traits after Five Days of Magnetic Stimulations |
| title_short | Increased Accuracy of Emotion Recognition in Individuals with Autism-Like Traits after Five Days of Magnetic Stimulations |
| title_sort | increased accuracy of emotion recognition in individuals with autism like traits after five days of magnetic stimulations |
| url | http://dx.doi.org/10.1155/2020/9857987 |
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