The histone demethylase KDM5C enhances the sensitivity of acute myeloid leukemia cells to lenalidomide by stabilizing cereblon

The histone demethylase KDM5C enhances the sensitivity of acute myeloid leukemia cells to lenalidomide by stabilizing cereblon

Abstract Background The protein cereblon (CRBN) mediates the antileukemia effect of lenalidomide (Len). Len binds to CRBN, recruits IKZF1/IKZF3, and promotes their ubiquitination and degradation, through which Len exhibits its antileukemia and antimyeloma activity. Therefore, the protein level of CR...

Full description

Saved in:
Bibliographic Details
Main Authors: Lu Zou, Dan Cao, Qing Sun, Wenjun Yu, Bingzong Li, Guoqiang Xu, Liang Zhou
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cellular & Molecular Biology Letters
Subjects:
Cereblon (CRBN)
KDM5C
Leukemia
Lenalidomide
Cell viability
Online Access:https://doi.org/10.1186/s11658-025-00697-8
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items